| The comprehensive in vitro proarrhythmia assay (CiPA) initiative—update on progress T Colatsky, B Fermini, G Gintant, JB Pierson, P Sager, Y Sekino, ... Journal of pharmacological and toxicological methods 81, 15-20, 2016 | 385 | 2016 |
| International multisite study of human-induced pluripotent stem cell-derived cardiomyocytes for drug proarrhythmic potential assessment K Blinova, Q Dang, D Millard, G Smith, J Pierson, L Guo, M Brock, HR Lu, ... Cell reports 24 (13), 3582-3592, 2018 | 289 | 2018 |
| Cross-site reliability of human induced pluripotent stem cell-derived cardiomyocyte based safety assays using microelectrode arrays: results from a blinded CiPA pilot study D Millard, Q Dang, H Shi, X Zhang, C Strock, U Kraushaar, H Zeng, ... Toxicological Sciences 164 (2), 550-562, 2018 | 96 | 2018 |
| The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium BD Guth, AY Chiang, J Doyle, MJ Engwall, JM Guillon, P Hoffmann, ... Journal of Pharmacological and Toxicological Methods 75, 70-90, 2015 | 53 | 2015 |
| Can non‐clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium E Park, GA Gintant, D Bi, D Kozeli, SD Pettit, JB Pierson, M Skinner, ... British journal of pharmacology 175 (4), 606-617, 2018 | 51 | 2018 |
| Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and … AJS Ribeiro, BD Guth, M Engwall, S Eldridge, CM Foley, L Guo, G Gintant, ... Frontiers in Pharmacology 10, 934, 2019 | 45 | 2019 |
| Evaluating uncertainty to strengthen epidemiologic data for use in human health risk assessments CJ Burns, JM Wright, JB Pierson, TF Bateson, I Burstyn, DA Goldstein, ... Environmental health perspectives 122 (11), 1160-1165, 2014 | 43 | 2014 |
| Determining risk markers for gonorrhea and chlamydial infection and reinfection among adolescents in public high schools GL Anschuetz, JN Beck, L Asbel, M Goldberg, ME Salmon, CV Spain Sexually transmitted diseases, 4-8, 2009 | 41 | 2009 |
| Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells J Kramer, HM Himmel, A Lindqvist, S Stoelzle-Feix, KW Chaudhary, D Li, ... Scientific reports 10 (1), 5627, 2020 | 39 | 2020 |
| Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations G Gintant, EP Kaushik, T Feaster, S Stoelzle-Feix, Y Kanda, T Osada, ... Regulatory toxicology and pharmacology 117, 104756, 2020 | 34 | 2020 |
| Non-lethal endotoxin injection: a rat model of hypercoagulability MB Brooks, JR Turk, A Guerrero, PK Narayanan, JP Nolan, EG Besteman, ... PLoS One 12 (1), e0169976, 2017 | 33 | 2017 |
| A public–private consortium advances cardiac safety evaluation: Achievements of the HESI Cardiac Safety Technical Committee JB Pierson, BR Berridge, MB Brooks, K Dreher, J Koerner, AE Schultze, ... Journal of Pharmacological and Toxicological Methods 68 (1), 7-12, 2013 | 33 | 2013 |
| Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms ER Pfeiffer-Kaushik, GL Smith, B Cai, GT Dempsey, MP Hortigon-Vinagre, ... Journal of Pharmacological and Toxicological Methods 99, 106612, 2019 | 31 | 2019 |
| Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General … BD Guth, M Engwall, S Eldridge, CM Foley, L Guo, G Gintant, J Koerner, ... Frontiers in pharmacology 10, 884, 2019 | 27 | 2019 |
| Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca2+ Imaging Assay: Evaluation of 28 CiPA … HR Lu, H Zeng, R Kettenhofen, L Guo, I Kopljar, K van Ammel, F Tekle, ... Toxicological Sciences 170 (2), 345-356, 2019 | 21 | 2019 |
| The challenges of predicting drug-induced QTc prolongation in humans JP Valentin, P Hoffmann, C Ortemann-Renon, J Koerner, J Pierson, ... Toxicological Sciences 187 (1), 3-24, 2022 | 17 | 2022 |
| Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study SZ Imam, Z He, E Cuevas, H Rosas-Hernandez, SM Lantz, S Sarkar, ... Experimental Biology and Medicine 243 (3), 228-236, 2018 | 17 | 2018 |
| A proof-of-concept evaluation of JTPc and Tp-Tec as proarrhythmia biomarkers in preclinical species: a retrospective analysis by an HESI-sponsored consortium E Boulay, MM Abernathy, R Chui, GS Friedrichs, N Gendron-Parra, ... International Journal of Toxicology 38 (1), 23-32, 2019 | 13 | 2019 |
| An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs MK Pugsley, B Guth, AY Chiang, JM Doyle, M Engwall, JM Guillon, ... Journal of Pharmacological and Toxicological Methods 85, 1-21, 2017 | 13 | 2017 |
| Can we panelize seizure? R Roberts, S Authier, RD Mellon, M Morton, I Suzuki, RB Tjalkens, ... Toxicological Sciences 179 (1), 3-13, 2021 | 11 | 2021 |
