Luke Alderwick
Luke Alderwick
Lecturer in Molecular Microbiology, University of Birmingham
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Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
SM Batt, T Jabeen, V Bhowruth, L Quill, PA Lund, L Eggeling, ...
Proceedings of the National Academy of Sciences 109 (28), 11354-11359, 2012
Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis
LJ Alderwick, M Seidel, H Sahm, GS Besra, L Eggeling
Journal of Biological Chemistry 281 (23), 15653-15661, 2006
The mycobacterial cell wall—peptidoglycan and arabinogalactan
LJ Alderwick, J Harrison, GS Lloyd, HL Birch
Cold Spring Harbor perspectives in medicine 5 (8), a021113, 2015
Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a …
LJ Alderwick, E Radmacher, M Seidel, R Gande, PG Hitchen, HR Morris, ...
Journal of Biological Chemistry 280 (37), 32362-32371, 2005
Ethambutol, a cell wall inhibitor of Mycobacterium tuberculosis, elicits L-glutamate efflux of Corynebacterium glutamicum
E Radmacher, KC Stansen, GS Besra, LJ Alderwick, WN Maughan, ...
Microbiology 151 (5), 1359-1368, 2005
Identification of a novel arabinofuranosyltransferase AftB involved in a terminal step of cell wall arabinan biosynthesis in Corynebacterianeae, such as Corynebacterium …
M Seidel, LJ Alderwick, HL Birch, H Sahm, L Eggeling, GS Besra
Journal of Biological Chemistry 282 (20), 14729-14740, 2007
Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new …
LJ Alderwick, HL Birch, AK Mishra, L Eggeling, GS Besra
Biochemical Society Transactions 35 (5), 1325-1328, 2007
Biosynthesis of mycobacterial arabinogalactan: identification of a novel α (1→ 3) arabinofuranosyltransferase
HL Birch, LJ Alderwick, A Bhatt, D Rittmann, K Krumbach, A Singh, Y Bai, ...
Molecular microbiology 69 (5), 1191-1206, 2008
Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis
LJ Alderwick, V Molle, L Kremer, AJ Cozzone, TR Dafforn, GS Besra, ...
Proceedings of the National Academy of Sciences 103 (8), 2558-2563, 2006
Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum
E Radmacher, LJ Alderwick, GS Besra, AK Brown, KJC Gibson, H Sahm, ...
Microbiology 151 (7), 2421-2427, 2005
Identification of an α (1→ 6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in …
AK Mishra, LJ Alderwick, D Rittmann, RVV Tatituri, J Nigou, M Gilleron, ...
Molecular microbiology 65 (6), 1503-1517, 2007
The C-Terminal Domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC Is a Lectin-Like Carbohydrate Binding Module
LJ Alderwick, GS Lloyd, H Ghadbane, JW May, A Bhatt, L Eggeling, ...
PLoS pathogens 7 (2), e1001299, 2011
Identification of a novel α(1→6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a …
AK Mishra, LJ Alderwick, D Rittmann, C Wang, A Bhatt, WR Jacobs Jr, ...
Molecular microbiology 68 (6), 1595-1613, 2008
A truncated lipoglycan from mycobacteria with altered immunological properties
HL Birch, LJ Alderwick, BJ Appelmelk, J Maaskant, A Bhatt, A Singh, ...
Proceedings of the National Academy of Sciences 107 (6), 2634-2639, 2010
Non-replicating Mycobacterium tuberculosis elicits a reduced infectivity profile with corresponding modifications to the cell wall and extracellular matrix
J Bacon, LJ Alderwick, JA Allnutt, E Gabasova, R Watson, KA Hatch, ...
PloS one 9 (2), e87329, 2014
Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells
EJ O’Donoghue, N Sirisaengtaksin, DF Browning, E Bielska, M Hadis, ...
PLoS pathogens 13 (11), e1006760, 2017
Arabinan-deficient mutants of Corynebacterium glutamicum and the consequent flux in decaprenylmonophosphoryl-d-arabinose metabolism
LJ Alderwick, LG Dover, M Seidel, R Gande, H Sahm, L Eggeling, ...
Glycobiology 16 (11), 1073-1081, 2006
Topology and mutational analysis of the single Emb arabinofuranosyltransferase of Corynebacterium glutamicum as a model of Emb proteins of Mycobacterium tuberculosis
M Seidel, LJ Alderwick, H Sahm, GS Besra, L Eggeling
Glycobiology 17 (2), 210-219, 2007
Activity of Bdellovibrio hit locus proteins, Bd0108 and Bd0109, links Type IVa pilus extrusion/retraction status to prey-independent growth signalling
MJ Capeness, C Lambert, AL Lovering, R Till, K Uchida, R Chaudhuri, ...
PloS one 8 (11), e79759, 2013
Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase
LJ Alderwick, GS Lloyd, AJ Lloyd, AL Lovering, L Eggeling, GS Besra
Glycobiology 21 (4), 410-425, 2011
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