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Michael Schlossmacher
Michael Schlossmacher
Senior Scientist, Ottawa Hospital Research Institute
Geverifieerd e-mailadres voor ohri.ca - Homepage
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Amyloid β-peptide is produced by cultured cells during normal metabolism
C Haass, MG Schlossmacher, AY Hung, C Vigo-Pelfrey, A Mellon, ...
Nature 359 (6393), 322-325, 1992
27361992
Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
P Seubert, C Vigo-Pelfrey, F Esch, M Lee, H Dovey, D Davis, S Sinha, ...
Nature 359 (6393), 325-327, 1992
23931992
Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic Lewy body disease
JP Anderson, DE Walker, JM Goldstein, R De Laat, K Banducci, ...
Journal of Biological Chemistry 281 (40), 29739-29752, 2006
15922006
Ubiquitination of a new form of α-synuclein by parkin from human brain: implications for Parkinson's disease
H Shimura, MG Schlossmacher, N Hattori, MP Frosch, A Trockenbacher, ...
Science 293 (5528), 263-269, 2001
13862001
Dopamine covalently modifies and functionally inactivates parkin
MJ LaVoie, BL Ostaszewski, A Weihofen, MG Schlossmacher, DJ Selkoe
Nature medicine 11 (11), 1214-1221, 2005
8282005
Detection of oligomeric forms of α‐synuclein protein in human plasma as a potential biomarker for Parkinson's disease
OMA El‐Agnaf, SA Salem, KE Paleologou, MD Curran, MJ Gibson, ...
The FASEB journal 20 (3), 419-425, 2006
8022006
beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.
C Haass, AY Hung, MG Schlossmacher, DB Teplow, DJ Selkoe
Journal of Biological Chemistry 268 (5), 3021-3024, 1993
7161993
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study
B Mollenhauer, JJ Locascio, W Schulz-Schaeffer, F Sixel-Döring, ...
The Lancet Neurology 10 (3), 230-240, 2011
7142011
Molecular markers of early Parkinson's disease based on gene expression in blood
CR Scherzer, AC Eklund, LJ Morse, Z Liao, JJ Locascio, D Fefer, ...
Proceedings of the National Academy of Sciences 104 (3), 955-960, 2007
5952007
Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease
T Tokuda, SA Salem, D Allsop, T Mizuno, M Nakagawa, MM Qureshi, ...
Biochemical and biophysical research communications 349 (1), 162-166, 2006
5112006
Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
B Mollenhauer, V Cullen, I Kahn, B Krastins, TF Outeiro, I Pepivani, J Ng, ...
Experimental neurology 213 (2), 315-325, 2008
4522008
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies
MG Schlossmacher, MP Frosch, WP Gai, M Medina, N Sharma, L Forno, ...
The American journal of pathology 160 (5), 1655-1667, 2002
4152002
Aggregated α-synuclein mediates dopaminergic neurotoxicity in vivo
M Periquet, T Fulga, L Myllykangas, MG Schlossmacher, MB Feany
Journal of Neuroscience 27 (12), 3338-3346, 2007
4142007
Acid β‐glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α‐synuclein processing
V Cullen, SP Sardi, J Ng, YH Xu, Y Sun, JJ Tomlinson, P Kolodziej, I Kahn, ...
Annals of neurology 69 (6), 940-953, 2011
3752011
Deciphering the role of heterozygous mutations in genes associated with parkinsonism
C Klein, K Lohmann-Hedrich, E Rogaeva, MG Schlossmacher, AE Lang
The Lancet Neurology 6 (7), 652-662, 2007
3592007
CNS expression of glucocerebrosidase corrects α-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
SP Sardi, J Clarke, C Kinnecom, TJ Tamsett, L Li, LM Stanek, MA Passini, ...
Proceedings of the National Academy of Sciences 108 (29), 12101-12106, 2011
3542011
Multiple system atrophy: a primary oligodendrogliopathy
GK Wenning, N Stefanova, KA Jellinger, W Poewe, MG Schlossmacher
Annals of Neurology: Official Journal of the American Neurological …, 2008
3472008
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
V Cullen, M Lindfors, J Ng, A Paetau, E Swinton, P Kolodziej, H Boston, ...
Molecular brain 2, 1-17, 2009
3312009
Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
M Hakimi, T Selvanantham, E Swinton, RF Padmore, Y Tong, G Kabbach, ...
Journal of neural transmission 118, 795-808, 2011
3292011
Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers
PP Pramstaller, MG Schlossmacher, TS Jacques, F Scaravilli, C Eskelson, ...
Annals of neurology 58 (3), 411-422, 2005
3242005
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