Bertram Klinger
Bertram Klinger
Postdoc in Computational Modelling in Medicine, Charité Universitätsmedizin Berlin
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Perturbation-response genes reveal signaling footprints in cancer gene expression
M Schubert, B Klinger, M Klünemann, A Sieber, F Uhlitz, S Sauer, ...
Nature Communications 9 (1), 11, 2018
Network quantification of EGFR signaling unveils potential for targeted combination therapy
B Klinger, A Sieber, R Fritsche‐Guenther, F Witzel, L Berry, ...
Molecular systems biology 9 (1), 673, 2013
Drug resistance mechanisms in colorectal cancer dissected with cell type–specific dynamic logic models
F Eduati, V Doldàn-Martelli, B Klinger, T Cokelaer, A Sieber, F Kogera, ...
Cancer research 77 (12), 3364-3375, 2017
Discovering causal signaling pathways through gene-expression patterns
JR Parikh, B Klinger, Y Xia, JA Marto, N Blï¿ ½thgen
Nucleic acids research 38 (suppl_2), W109-W117, 2010
Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
R Brandt, T Sell, M Lüthen, F Uhlitz, B Klinger, P Riemer, ...
Nature communications 10 (1), 1-15, 2019
Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS
I Stelniec‐Klotz, S Legewie, O Tchernitsa, F Witzel, B Klinger, C Sers, ...
Molecular systems biology 8 (1), 601, 2012
The role of the cancer stem cell marker CD271 in DNA damage response and drug resistance of melanoma cells
R Redmer, Walz, Klinger, Khouja, Welte, Schäfer
Oncogenesis 6 (1), e291, 2017
An immediate-late gene expression module decodes ERK signal duration
F Uhlitz, A Sieber, E Wyler, R Fritsche‐Guenther, J Meisig, M Landthaler, ...
Molecular Systems Biology 13 (5), 2017
Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum
JJ Staudacher, IS Naarmann-de Vries, SJ Ujvari, B Klinger, M Kasim, ...
Nucleic acids research 43 (6), 3219-3236, 2015
Isoform-specific Ras signaling is growth factor dependent
FE Hood, B Klinger, AU Newlaczyl, A Sieber, M Dorel, SP Oliver, ...
Molecular biology of the cell 30 (9), 1108-1117, 2019
Modelling signalling networks from perturbation data
M Dorel, B Klinger, T Gross, A Sieber, A Prahallad, E Bosdriesz, ...
Bioinformatics 34 (23), 4079-4086, 2018
SPEED2: inferring upstream pathway activity from differential gene expression
M Rydenfelt, B Klinger, M Klünemann, N Blüthgen
Nucleic Acids Research, 2020
SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells
K Klotz-Noack, B Klinger, M Rivera, N Bublitz, F Uhlitz, P Riemer, ...
Cell Reports 32 (12), 108184, 2020
Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A
N Rohwer, F Bindel, C Grimm, SJ Lin, J Wappler, B Klinger, N Blüthgen, ...
Oncotarget 7 (6), 6693, 2016
Computer-assisted curation of a human regulatory core network from the biological literature
P Thomas, P Durek, I Solt, B Klinger, F Witzel, P Schulthess, Y Mayer, ...
Bioinformatics 31 (8), 1258-1266, 2015
Consequences of feedback in signal transduction for targeted therapies
B Klinger, N Blüthgen
Biochemical Society Transactions 42 (4), 770-775, 2014
Multilevel regulation of HIF-1 signaling by TTP
M Fähling, AB Persson, B Klinger, E Benko, A Steege, M Kasim, A Patzak, ...
Molecular biology of the cell 23 (20), 4129-4141, 2012
Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma
U Schoetz, D Klein, J Hess, S Shnayien, S Spoerl, M Orth, S Mutlu, ...
Cell death & disease 12 (12), 1-14, 2021
Reverse engineering gene regulatory networks by modular response analysis–a benchmark
B Klinger, N Bluethgen
Essays In Biochemistry 62 (4), 535-547, 2018
Comparative Network Reconstruction using mixed integer programming
E Bosdriesz, A Prahallad, B Klinger, A Sieber, A Bosma, R Bernards, ...
Bioinformatics 34 (17), i997-i1004, 2018
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