Prof. Assaf Friedler

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Zvi HayoukaThe Robert H. Smith Faculty of Agriculture, Food and Environment,The Hebrew University of JerusalemVerified email at mail.huji.ac.il
Alan FershtEmeritus Group Leader, MRC Laboratory of Molecular Biology, University of CambridgeVerified email at cam.ac.uk
Dmitry VeprintsevProfessor of Molecular and Cellular Pharmacology, University of NottinghamVerified email at nottingham.ac.uk
Deborah E ShalevHebrew University of JerusalemVerified email at mail.huji.ac.il
Michal MaesInstitute of Systems BiologyVerified email at isbscience.org
Mattan HurevichAssociate Professor, Institute of Chemistry The Hebrew UniversityVerified email at mail.huji.ac.il
Joseph RosenbluhDepartment of Biochemistry & Molecular Biology, Monash UniversityVerified email at monash.edu
Oded LivnahVerified email at mail.huji.ac.il
Rachel NechushtaiThe Hebrew University of JerusalemVerified email at mail.huji.ac.il
Shahar SukenikDept. of Chemistry and Biochemistry, UC MercedVerified email at ucmerced.edu
Eric J SundbergEmory University School of MedicineVerified email at emory.edu
KOUSHIK CHANDRAAssociate Professor in ChemistryVerified email at midnaporecollege.ac.in
Daniel HarriesInstitute of Chemistry, The Hebrew UniversityVerified email at mail.huji.ac.il
Hermona SoreqProfessor of Molecular Neurobiology, The Hebrew University of JerusalemVerified email at mail.huji.ac.il
Penka NikolovaEmeritus Associate Professor (Reader), King's College LondonVerified email at kcl.ac.uk
Daniel BonsorFrederick National Laboratory for Cancer ResearchVerified email at nih.gov
Patricia A. JenningsProfessor of Chemistry and Biochemistry, UCSDVerified email at ucsd.edu
Masha NivThe Hebrew UniversityVerified email at mail.huji.ac.il
Tiago RitoThe Francis Crick InstituteVerified email at crick.ac.uk
Shoshana RavidProfessor of BiochemistryVerified email at mail.huji.ac.il

Prof. Assaf Friedler

Institute of Chemistry, The Hebrew University of Jerusalem

Verified email at mail.huji.ac.il - Homepage

peptides protein interactions medicinal chemistry biophysical chemistry intrinsically disordered proteins


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Molecular mechanism of the interaction between MDM2 and p53 O Schon, A Friedler, M Bycroft, SMV Freund, AR Fersht Journal of molecular biology 323 (3), 491-501, 2002	447	2002
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants A Friedler, LO Hansson, DB Veprintsev, SMV Freund, TM Rippin, ... Proceedings of the National Academy of Sciences 99 (2), 937-942, 2002	342	2002
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium Z Hayouka, J Rosenbluh, A Levin, S Loya, M Lebendiker, D Veprintsev, ... Proceedings of the National Academy of Sciences 104 (20), 8316-8321, 2007	232	2007
Studying protein–protein interactions using peptide arrays C Katz, L Levy-Beladev, S Rotem-Bamberger, T Rito, SGD Rüdiger, ... Chemical Society Reviews 40 (5), 2131-2145, 2011	230	2011
Butyrylcholinesterase attenuates amyloid fibril formation in vitro S Diamant, E Podoly, A Friedler, H Ligumsky, O Livnah, H Soreq Proceedings of the National Academy of Sciences 103 (23), 8628-8633, 2006	202	2006
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide N Issaeva, A Friedler, P Bozko, KG Wiman, AR Fersht, G Selivanova Proceedings of the National Academy of Sciences 100 (23), 13303-13307, 2003	194	2003
The C terminus of p53 binds the N-terminal domain of MDM2 MV Poyurovsky, C Katz, O Laptenko, R Beckerman, M Lokshin, J Ahn, ... Nature structural & molecular biology 17 (8), 982-989, 2010	172	2010
Kinetic instability of p53 core domain mutants: implications for rescue by small molecules A Friedler, DB Veprintsev, LO Hansson, AR Fersht Journal of Biological Chemistry 278 (26), 24108-24112, 2003	168	2003
Two sequence motifs from HIF-1α bind to the DNA-binding site of p53 LO Hansson, A Friedler, S Freund, S Rüdiger, AR Fersht Proceedings of the National Academy of Sciences 99 (16), 10305-10309, 2002	168	2002
Modulation of binding of DNA to the C-terminal domain of p53 by acetylation A Friedler, DB Veprintsev, SMV Freund, KI von Glos, AR Fersht Structure 13 (4), 629-636, 2005	113	2005
Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation D Mayer, FF Damberger, M Samarasimhareddy, M Feldmueller, ... Nature communications 10 (1), 1261, 2019	105	2019
The structure of an FF domain from human HYPA/FBP11 M Allen, A Friedler, O Schon, M Bycroft Journal of molecular biology 323 (3), 411-416, 2002	105	2002
Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for “mutant conformation” A Friedler, BS DeDecker, SMV Freund, C Blair, S Rüdiger, AR Fersht Journal of molecular biology 336 (1), 187-196, 2004	85	2004
Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein Z Hayouka, M Hurevich, A Levin, H Benyamini, A Iosub, M Maes, ... Bioorganic & medicinal chemistry 18 (23), 8388-8395, 2010	81	2010
Chemical synthesis and expression of the HIV‐1 Rev protein P Siman, O Blatt, T Moyal, T Danieli, M Lebendiker, HA Lashuel, ... ChemBioChem 12 (7), 1097-1104, 2011	80	2011
Development of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motif A Friedler, D Friedler, NW Luedtke, Y Tor, A Loyter, C Gilon Journal of biological chemistry 275 (31), 23783-23789, 2000	79	2000
Backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in … A Friedler, N Zakai, O Karni, YC Broder, L Baraz, M Kotler, A Loyter, ... Biochemistry 37 (16), 5616-5622, 1998	79	1998
Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes O Schon, A Friedler, S Freund, AR Fersht Journal of molecular biology 336 (1), 197-202, 2004	78	2004
Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling J Petersen, SC Wright, D Rodríguez, P Matricon, N Lahav, A Vromen, ... Nature communications 8 (1), 226, 2017	76	2017
Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53 A Friedler, DB Veprintsev, T Rutherford, KI von Glos, AR Fersht Journal of Biological Chemistry 280 (9), 8051-8059, 2005	75	2005

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