Julia Flynn
Julia Flynn
Verified email at umassmed.edu
Title
Cited by
Cited by
Year
Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals
JM Flynn, SB Neher, YI Kim, RT Sauer, TA Baker
Molecular cell 11 (3), 671-683, 2003
6262003
Sculpting the proteome with AAA+ proteases and disassembly machines
RT Sauer, DN Bolon, BM Burton, RE Burton, JM Flynn, RA Grant, ...
Cell 119 (1), 9-18, 2004
4752004
Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis
JM Flynn, I Levchenko, M Seidel, SH Wickner, RT Sauer, TA Baker
Proceedings of the National Academy of Sciences 98 (19), 10584-10589, 2001
3152001
Modulating substrate choice: the SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation
JM Flynn, I Levchenko, RT Sauer, TA Baker
Genes & development 18 (18), 2292-2301, 2004
2302004
Design principles of the proteolytic cascade governing the σE-mediated envelope stress response in Escherichia coli: keys to graded, buffered, and rapid signal transduction
R Chaba, IL Grigorova, JM Flynn, TA Baker, CA Gross
Genes & development 21 (1), 124-136, 2007
1252007
Latent ClpX-recognition signals ensure LexA destruction after DNA damage
SB Neher, JM Flynn, RT Sauer, TA Baker
Genes & development 17 (9), 1084-1089, 2003
1242003
Systematic mutant analyses elucidate general and client-specific aspects of Hsp90 function
P Mishra, JM Flynn, TN Starr, DNA Bolon
Cell reports 15 (3), 588-598, 2016
772016
Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments
K Nakano, J Chen, GE Tarr, T Yoshida, JM Flynn, MW Bitensky
Proceedings of the National Academy of Sciences 98 (8), 4693-4698, 2001
552001
Pervasive contingency and entrenchment in a billion years of Hsp90 evolution
TN Starr, JM Flynn, P Mishra, DNA Bolon, JW Thornton
Proceedings of the National Academy of Sciences 115 (17), 4453-4458, 2018
542018
Versatile modes of peptide recognition by the AAA+ adaptor protein SspB
I Levchenko, RA Grant, JM Flynn, RT Sauer, TA Baker
Nature structural & molecular biology 12 (6), 520-525, 2005
542005
Viewing protein fitness landscapes through a next-gen lens
JI Boucher, P Cote, J Flynn, L Jiang, A Laban, P Mishra, BP Roscoe, ...
Genetics 198 (2), 461-471, 2014
532014
Mechanistic asymmetry in Hsp90 dimers
JM Flynn, P Mishra, DNA Bolon
Journal of molecular biology 427 (18), 2904-2911, 2015
302015
Expression of N-formylated proteins in Escherichia coli
S Spector, JM Flynn, B Tidor, TA Baker, RT Sauer
Protein expression and purification 32 (2), 317-322, 2003
242003
Evolutionary mechanisms studied through protein fitness landscapes
AS Canale, PA Cote-Hammarlof, JM Flynn, DNA Bolon
Current opinion in structural biology 48, 141-148, 2018
192018
Comprehensive fitness maps of Hsp90 show widespread environmental dependence
JM Flynn, A Rossouw, P Cote-Hammarlof, I Fragata, D Mavor, C Hollins III, ...
Elife 9, e53810, 2020
132020
Substrate selection by the ClpXP protease: a tail of destruction
JM Flynn
Massachusetts Institute of Technology, 2004
42004
The adaptive potential of the middle domain of yeast Hsp90
PA Cote-Hammarlof, I Fragata, J Flynn, D Mavor, KB Zeldovich, C Bank, ...
Molecular Biology and Evolution 38 (2), 368-379, 2021
12021
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JM Flynn, A Rossouw, PA Cote-Hammarlof, I Fragata, D Mavor, C Hollins, ...
2019
Investigating the influence of environment on the evolution of Hsp90 using comprehensive fitness maps [preprint]
JM Flynn, A Rossouw, PA Cote-Hammarlof, I Fragata, D Mavor, ...
2019
The adaptive potential of the M-domain of yeast Hsp90 [preprint]
PA Cote-Hammarlof, I Fragata, JM Flynn, KB Zeldovich, C Bank, ...
2019
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Articles 1–20