Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment MS Shafat, T Oellerich, S Mohr, SD Robinson, DR Edwards, CR Marlein, ... Blood, The Journal of the American Society of Hematology 129 (10), 1320-1332, 2017 | 296 | 2017 |
NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts CR Marlein, L Zaitseva, RE Piddock, SD Robinson, DR Edwards, ... Blood, The Journal of the American Society of Hematology 130 (14), 1649-1660, 2017 | 291 | 2017 |
PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer F Brasó-Maristany, S Filosto, S Catchpole, R Marlow, J Quist, ... Nature medicine 22 (11), 1303-1313, 2016 | 226 | 2016 |
The bone marrow microenvironment–Home of the leukemic blasts MS Shafat, B Gnaneswaran, KM Bowles, SA Rushworth Blood reviews 31 (5), 277-286, 2017 | 147 | 2017 |
MIF-induced stromal PKCβ/IL8 is essential in human acute myeloid leukemia AM Abdul-Aziz, MS Shafat, TK Mehta, F Di Palma, MJ Lawes, ... Cancer research 77 (2), 303-311, 2017 | 88 | 2017 |
Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment AM Abdul-Aziz, Y Sun, C Hellmich, CR Marlein, J Mistry, E Forde, ... Blood, The Journal of the American Society of Hematology 133 (5), 446-456, 2019 | 83 | 2019 |
Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML L Zaitseva, MY Murray, MS Shafat, MJ Lawes, DJ MacEwan, KM Bowles, ... Oncotarget 5 (20), 9930, 2014 | 79 | 2014 |
Inflammatory differences in plaque erosion and rupture in patients with ST‐segment elevation myocardial infarction S Chandran, J Watkins, A Abdul‐Aziz, M Shafat, PA Calvert, KM Bowles, ... Journal of the American Heart Association 6 (5), e005868, 2017 | 51 | 2017 |
Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection G Pillinger, NV Loughran, RE Piddock, MS Shafat, L Zaitseva, ... Oncotarget 7 (26), 39784, 2016 | 36 | 2016 |
HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia AM Abdul-Aziz, MS Shafat, Y Sun, CR Marlein, RE Piddock, SD Robinson, ... Oncogene 37 (20), 2676-2686, 2018 | 29 | 2018 |
Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC RE Piddock, CR Marlein, A Abdul-Aziz, MS Shafat, MJ Auger, KM Bowles, ... Journal of hematology & oncology 11, 1-4, 2018 | 22 | 2018 |
Cellular therapeutic approaches to cytomegalovirus infection following allogeneic stem cell transplantation MS Shafat, V Mehra, KS Peggs, C Roddie Frontiers in Immunology 11, 550178, 2020 | 20 | 2020 |
Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells SA Rushworth, G Pillinger, A Abdul-Aziz, R Piddock, MS Shafat, ... The Lancet Haematology 2 (5), e204-e211, 2015 | 20 | 2015 |
Erratum: PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer F Braso-Maristany, S Filosto, S Catchpole, R Marlow, J Quist, ... Nature medicine 23 (4), 526, 2017 | 8 | 2017 |
Stent encrustation in feline and human artificial urine: does the low molecular weight composition account for the difference? M Shafat, K Rajakumar, H Syme, N Buchholz, MM Knight Urolithiasis 41, 481-486, 2013 | 8 | 2013 |
PGC1α driven mitochondrial biogenesis within the bone marrow stromal cells of the acute myeloid leukemia micro-environment is a pre-requisite for mitochondrial transfer to … C Marlein, L Zaitseva, R Piddock, M Shafat, A Collins, K Bowles, ... Blood 130, 3927, 2017 | 6 | 2017 |
Pembrolizumab for the treatment of progressive multifocal leukoencephalopathy following anti‐CD19 CAR‐T therapy: a case report S Mackenzie, M Shafat, H Roddy, H Hyare, L Neill, MAV Marzolini, ... EJHaem 2 (4), 848-853, 2021 | 5 | 2021 |
Synthesis of Carboxamide‐Containing Tranylcypromine Analogues as LSD1 (KDM1A) Inhibitors Targeting Acute Myeloid Leukemia M Teresa Borrello, H Benelkebir, A Lee, C Hin Tam, M Shafat, ... ChemMedChem 16 (8), 1316-1324, 2021 | 5 | 2021 |
Dual activation of NRF2 in multiple myeloma and bone marrow mesenchymal stromal cells regulates chemotherapy resistance Y Sun, L Zaitseva, MS Shafat, KM Bowles, SA Rushworth Blood, The Journal of the American Society of Hematology 128 (22), 3287-3287, 2016 | 5 | 2016 |
Multi-organ graft-versus-host disease after nivolumab for relapsed Hodgkin lymphoma: the role of plasma exchange R Amerikanou, L Neill, M Shafat, H Roddy, H Hyare, S Hughes, ... The Lancet Haematology 8 (11), e862, 2021 | 4 | 2021 |