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Neeltje Steeghs
Neeltje Steeghs
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Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer
S Kopetz, A Grothey, R Yaeger, E Van Cutsem, J Desai, T Yoshino, ...
New England Journal of Medicine 381 (17), 1632-1643, 2019
11612019
Pan-cancer whole-genome analyses of metastatic solid tumours
P Priestley, J Baber, MP Lolkema, N Steeghs, E de Bruijn, C Shale, ...
Nature 575 (7781), 210-216, 2019
7612019
Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors
KM Heinhuis, W Ros, M Kok, N Steeghs, JH Beijnen, JHM Schellens
Annals of Oncology 30 (2), 219-235, 2019
3832019
Encorafenib plus cetuximab as a new standard of care for previously treated BRAF V600E–mutant metastatic colorectal cancer: updated survival results and subgroup analyses from …
J Tabernero, A Grothey, E Van Cutsem, R Yaeger, H Wasan, T Yoshino, ...
Journal of Clinical Oncology 39 (4), 273, 2021
2992021
The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies
L Angus, M Smid, SM Wilting, J van Riet, A Van Hoeck, L Nguyen, ...
Nature genetics 51 (10), 1450-1458, 2019
2652019
Pervasive chromosomal instability and karyotype order in tumour evolution
TBK Watkins, EL Lim, M Petkovic, S Elizalde, NJ Birkbak, GA Wilson, ...
Nature 587 (7832), 126-132, 2020
2462020
Practical recommendations for therapeutic drug monitoring of kinase inhibitors in oncology
RB Verheijen, H Yu, JHM Schellens, JH Beijnen, N Steeghs, ...
Clinical Pharmacology & Therapeutics 102 (5), 765-776, 2017
2462017
Practical guidelines for therapeutic drug monitoring of anticancer tyrosine kinase inhibitors: focus on the pharmacokinetic targets
H Yu, N Steeghs, CM Nijenhuis, JHM Schellens, JH Beijnen, ...
Clinical pharmacokinetics 53, 305-325, 2014
2462014
The mutational footprints of cancer therapies
O Pich, F Muiños, MP Lolkema, N Steeghs, A Gonzalez-Perez, ...
Nature genetics 51 (12), 1732-1740, 2019
2392019
Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor
N Steeghs, H Gelderblom, J Roodt, O Christensen, P Rajagopalan, ...
Clinical Cancer Research 14 (11), 3470-3476, 2008
2322008
Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: an update of recent developments
N Steeghs, JWR Nortier, H Gelderblom
Annals of surgical oncology 14, 942-953, 2007
1832007
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
W Jiao, G Atwal, P Polak, R Karlic, E Cuppen, A Danyi, J de Ridder, ...
Nature communications 11 (1), 728, 2020
1642020
Pazopanib in advanced vascular sarcomas: an EORTC Soft Tissue and Bone Sarcoma Group (STBSG) retrospective analysis
A Kollár, RL Jones, S Stacchiotti, H Gelderblom, M Guida, G Grignani, ...
Acta oncologica 56 (1), 88-92, 2017
1602017
The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
LF van Dessel, J van Riet, M Smits, Y Zhu, P Hamberg, ...
Nature communications 10 (1), 5251, 2019
1512019
Molecular tumor boards: current practice and future needs
DL Van der Velden, CML Van Herpen, HWM Van Laarhoven, EF Smit, ...
Annals of Oncology 28 (12), 3070-3075, 2017
1472017
Therapeutic drug monitoring of oral targeted antineoplastic drugs
A Mueller-Schoell, SL Groenland, O Scherf-Clavel, M van Dyk, ...
European journal of clinical pharmacology 77, 441-464, 2021
1452021
Phase Ib study of MIW815 (ADU-S100) in combination with spartalizumab (PDR001) in patients (pts) with advanced/metastatic solid tumors or lymphomas.
F Meric-Bernstam, SK Sandhu, O Hamid, A Spreafico, S Kasper, ...
Journal of Clinical Oncology 37 (15_suppl), 2507-2507, 2019
1312019
Phase I pharmacokinetic and pharmacodynamic study of the aurora kinase inhibitor danusertib in patients with advanced or metastatic solid tumors
N Steeghs, FALM Eskens, H Gelderblom, J Verweij, JWR Nortier, ...
Journal of Clinical Oncology 27 (30), 5094-5101, 2009
1222009
Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours
NAG Lankheet, JSL Kloth, CGM Gadellaa-van Hooijdonk, GA Cirkel, ...
British journal of cancer 110 (10), 2441-2449, 2014
1072014
Plasma concentrations of tyrosine kinase inhibitors imatinib, erlotinib, and sunitinib in routine clinical outpatient cancer care
NAG Lankheet, LM Knapen, JHM Schellens, JH Beijnen, N Steeghs, ...
Therapeutic drug monitoring 36 (3), 326-334, 2014
1052014
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