Zhengyan 'George' Kan
Zhengyan 'George' Kan
Director of Computational Biology, Pfizer Inc.
Adresse e-mail validée de pfizer.com - Page d'accueil
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Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays
JM Johnson, J Castle, P Garrett-Engele, Z Kan, PM Loerch, CD Armour, ...
Science 302 (5653), 2141-2144, 2003
Diverse somatic mutation patterns and pathway alterations in human cancers
Z Kan, BS Jaiswal, J Stinson, V Janakiraman, D Bhatt, HM Stern, P Yue, ...
Nature 466 (7308), 869-873, 2010
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
RL Yauch, GJP Dijkgraaf, B Alicke, T Januario, CP Ahn, T Holcomb, ...
Science 326 (5952), 572-574, 2009
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
WK Sung, H Zheng, S Li, R Chen, X Liu, Y Li, NP Lee, WH Lee, ...
Nature genetics 44 (7), 765-769, 2012
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
K Wang, J Kan, ST Yuen, ST Shi, KM Chu, S Law, TL Chan, Z Kan, ...
Nature genetics 43 (12), 1219-1223, 2011
The BioMart community portal: an innovative alternative to large, centralized data repositories
D Smedley, S Haider, S Durinck, L Pandini, P Provero, J Allen, O Arnaiz, ...
Nucleic acids research 43 (W1), W589-W598, 2015
Gene structure prediction and alternative splicing analysis using genomically aligned ESTs
Z Kan, EC Rouchka, WR Gish
Genome Research 11 (5), 889-900, 2001
Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer
W Chung, HH Eum, HO Lee, KM Lee, HB Lee, KT Kim, HS Ryu, S Kim, ...
Nature communications 8 (1), 1-12, 2017
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
Z Kan, H Zheng, X Liu, S Li, TD Barber, Z Gong, H Gao, K Hao, ...
Genome research 23 (9), 1422-1433, 2013
Oncogenic ERBB3 mutations in human cancers
BS Jaiswal, NM Kljavin, EW Stawiski, E Chan, C Parikh, S Durinck, ...
Cancer cell 23 (5), 603-617, 2013
Somatic mutations in p85α promote tumorigenesis through class IA PI3K activation
BS Jaiswal, V Janakiraman, NM Kljavin, S Chaudhuri, HM Stern, W Wang, ...
Cancer cell 16 (6), 463-474, 2009
Selecting for functional alternative splices in ESTs
Z Kan, W Gish
Genome research 12 (12), 1837-1845, 2002
Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples
S Nacu, W Yuan, Z Kan, D Bhatt, CS Rivers, J Stinson, BA Peters, ...
BMC medical genomics 4 (1), 1-22, 2011
A comprehensive transcript index of the human genome generated using microarrays and computational approaches
EE Schadt, SW Edwards, D GuhaThakurta, D Holder, L Ying, V Svetnik, ...
Genome biology 5 (10), 1-17, 2004
Expression of alternatively spliced sodium channel α-subunit genes: unique splicing patterns are observed in dorsal root ganglia
CK Raymond, J Castle, P Garrett-Engele, CD Armour, Z Kan, ...
Journal of Biological Chemistry 279 (44), 46234-46241, 2004
Coevolution of PDZ domain–ligand interactions analyzed by high-throughput phage display and deep sequencing
A Ernst, D Gfeller, Z Kan, S Seshagiri, PM Kim, GD Bader, SS Sidhu
Molecular BioSystems 6 (10), 1782-1790, 2010
Evolutionarily conserved and diverged alternative splicing events show different expression and functional profiles
Z Kan, PW Garrett-Engele, JM Johnson, JC Castle
Nucleic acids research 33 (17), 5659-5666, 2005
Multi-omics profiling of younger Asian breast cancers reveals distinctive molecular signatures
Z Kan, Y Ding, J Kim, HH Jung, W Chung, S Lal, S Cho, ...
Nature communications 9 (1), 1-13, 2018
PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6)
YF Cheung, Z Kan, P Garrett-Engele, I Gall, H Murdoch, GS Baillie, ...
Journal of Pharmacology and Experimental Therapeutics 322 (2), 600-609, 2007
Decoding complex patterns of genomic rearrangement in hepatocellular carcinoma
J Fernandez-Banet, NP Lee, KT Chan, H Gao, X Liu, WK Sung, W Tan, ...
Genomics 103 (2-3), 189-203, 2014
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