|Bactericidal mode of action of bedaquiline|
K Hards, JR Robson, M Berney, L Shaw, D Bald, A Koul, K Andries, ...
Journal of Antimicrobial Chemotherapy 70 (7), 2028-2037, 2015
|Energetics of respiration and oxidative phosphorylation in mycobacteria|
GM Cook, K Hards, C Vilchèze, T Hartman, M Berney
Molecular Genetics of Mycobacteria, 389-409, 2014
|Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection|
NP Kalia, EJ Hasenoehrl, NB Ab Rahman, VH Koh, MLT Ang, DR Sajorda, ...
Proceedings of the National Academy of Sciences 114 (28), 7426-7431, 2017
|A soil actinobacterium scavenges atmospheric H2 using two membrane-associated, oxygen-dependent [NiFe] hydrogenases|
C Greening, M Berney, K Hards, GM Cook, R Conrad
Proceedings of the National Academy of Sciences 111 (11), 4257-4261, 2014
|Persistence of the dominant soil phylum Acidobacteria by trace gas scavenging|
C Greening, CR Carere, R Rushton-Green, LK Harold, K Hards, ...
Proceedings of the National Academy of Sciences 112 (33), 10497-10502, 2015
|Energetics of pathogenic bacteria and opportunities for drug development|
GM Cook, C Greening, K Hards, M Berney
Advances in microbial physiology 65, 1-62, 2014
|Mixotrophy drives niche expansion of verrucomicrobial methanotrophs|
CR Carere, K Hards, KM Houghton, JF Power, B McDonald, C Collet, ...
The ISME journal 11 (11), 2599-2610, 2017
|Atmospheric hydrogen scavenging: from enzymes to ecosystems|
C Greening, P Constant, K Hards, SE Morales, JG Oakeshott, RJ Russell, ...
Applied and Environmental Microbiology 81 (4), 1190-1199, 2015
|Oxidative phosphorylation as a target space for tuberculosis: success, caution, and future directions|
GM Cook, K Hards, E Dunn, A Heikal, Y Nakatani, C Greening, DC Crick, ...
Tuberculosis and the Tubercle Bacillus, 295-316, 2017
|Ionophoric effects of the antitubercular drug bedaquiline|
K Hards, DGG McMillan, LA Schurig-Briccio, RB Gennis, H Lill, D Bald, ...
Proceedings of the National Academy of Sciences 115 (28), 7326-7331, 2018
|Targeting bacterial energetics to produce new antimicrobials|
K Hards, GM Cook
Drug Resistance Updates 36, 1-12, 2018
|Pyrazolo[1,5-a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis|
X Lu, Z Williams, K Hards, J Tang, CY Cheung, HL Aung, B Wang, Z Liu, ...
ACS infectious diseases 5 (2), 239-249, 2018
|Essentiality of succinate dehydrogenase in Mycobacterium smegmatis and its role in the generation of the membrane potential under hypoxia|
I Pecsi, K Hards, N Ekanayaka, M Berney, T Hartman, WR Jacobs Jr, ...
MBio 5 (4), e01093-14, 2014
|Three different [NiFe] hydrogenases confer metabolic flexibility in the obligate aerobe Mycobacterium smegmatis|
M Berney, C Greening, K Hards, D Collins, GM Cook
Environmental microbiology 16 (1), 318-330, 2014
|Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering|
BM Lee, LK Harold, DV Almeida, L Afriat-Jurnou, HL Aung, BM Forde, ...
PLoS pathogens 16 (2), e1008287, 2020
|Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis|
BS Lee, K Hards, CA Engelhart, EJ Hasenoehrl, NP Kalia, JS Mackenzie, ...
EMBO Molecular Medicine 13 (1), e13207, 2021
|Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death|
A Heikal, K Hards, CY Cheung, A Menorca, MSM Timmer, BL Stocker, ...
Journal of Antimicrobial Chemotherapy 71 (10), 2840-2847, 2016
|The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria|
MB McNeil, HG Hampton, KJ Hards, BNJ Watson, GM Cook, PC Fineran
FEBS letters 588 (3), 414-421, 2014
|Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis|
WG Saw, ML Wu, P Ragunathan, G Biuković, AM Lau, J Shin, ...
Scientific reports 9 (1), 16759, 2019
|The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB|
S Safarian, HK Opel-Reading, D Wu, AR Mehdipour, K Hards, LK Harold, ...
Nature Communications 12 (1), 5236, 2021