Bactericidal mode of action of bedaquiline K Hards, JR Robson, M Berney, L Shaw, D Bald, A Koul, K Andries, ... Journal of Antimicrobial Chemotherapy 70 (7), 2028-2037, 2015 | 190 | 2015 |
Energetics of respiration and oxidative phosphorylation in mycobacteria GM Cook, K Hards, C Vilchèze, T Hartman, M Berney Molecular Genetics of Mycobacteria, 389-409, 2014 | 185* | 2014 |
Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection NP Kalia, EJ Hasenoehrl, NB Ab Rahman, VH Koh, MLT Ang, DR Sajorda, ... Proceedings of the National Academy of Sciences 114 (28), 7426-7431, 2017 | 151 | 2017 |
A soil actinobacterium scavenges atmospheric H2 using two membrane-associated, oxygen-dependent [NiFe] hydrogenases C Greening, M Berney, K Hards, GM Cook, R Conrad Proceedings of the National Academy of Sciences 111 (11), 4257-4261, 2014 | 126 | 2014 |
Persistence of the dominant soil phylum Acidobacteria by trace gas scavenging C Greening, CR Carere, R Rushton-Green, LK Harold, K Hards, ... Proceedings of the National Academy of Sciences 112 (33), 10497-10502, 2015 | 112 | 2015 |
Energetics of pathogenic bacteria and opportunities for drug development GM Cook, C Greening, K Hards, M Berney Advances in microbial physiology 65, 1-62, 2014 | 112 | 2014 |
Mixotrophy drives niche expansion of verrucomicrobial methanotrophs CR Carere, K Hards, KM Houghton, JF Power, B McDonald, C Collet, ... The ISME journal 11 (11), 2599-2610, 2017 | 98 | 2017 |
Atmospheric hydrogen scavenging: from enzymes to ecosystems C Greening, P Constant, K Hards, SE Morales, JG Oakeshott, RJ Russell, ... Applied and Environmental Microbiology 81 (4), 1190-1199, 2015 | 85 | 2015 |
Oxidative phosphorylation as a target space for tuberculosis: success, caution, and future directions GM Cook, K Hards, E Dunn, A Heikal, Y Nakatani, C Greening, DC Crick, ... Tuberculosis and the Tubercle Bacillus, 295-316, 2017 | 84 | 2017 |
Ionophoric effects of the antitubercular drug bedaquiline K Hards, DGG McMillan, LA Schurig-Briccio, RB Gennis, H Lill, D Bald, ... Proceedings of the National Academy of Sciences 115 (28), 7326-7331, 2018 | 80 | 2018 |
Targeting bacterial energetics to produce new antimicrobials K Hards, GM Cook Drug Resistance Updates 36, 1-12, 2018 | 74 | 2018 |
Pyrazolo[1,5-a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis X Lu, Z Williams, K Hards, J Tang, CY Cheung, HL Aung, B Wang, Z Liu, ... ACS infectious diseases 5 (2), 239-249, 2018 | 67 | 2018 |
Essentiality of succinate dehydrogenase in Mycobacterium smegmatis and its role in the generation of the membrane potential under hypoxia I Pecsi, K Hards, N Ekanayaka, M Berney, T Hartman, WR Jacobs Jr, ... MBio 5 (4), e01093-14, 2014 | 67 | 2014 |
Three different [NiFe] hydrogenases confer metabolic flexibility in the obligate aerobe Mycobacterium smegmatis M Berney, C Greening, K Hards, D Collins, GM Cook Environmental microbiology 16 (1), 318-330, 2014 | 61 | 2014 |
Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering BM Lee, LK Harold, DV Almeida, L Afriat-Jurnou, HL Aung, BM Forde, ... PLoS pathogens 16 (2), e1008287, 2020 | 50 | 2020 |
Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis BS Lee, K Hards, CA Engelhart, EJ Hasenoehrl, NP Kalia, JS Mackenzie, ... EMBO Molecular Medicine 13 (1), e13207, 2021 | 40 | 2021 |
Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death A Heikal, K Hards, CY Cheung, A Menorca, MSM Timmer, BL Stocker, ... Journal of Antimicrobial Chemotherapy 71 (10), 2840-2847, 2016 | 40 | 2016 |
The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria MB McNeil, HG Hampton, KJ Hards, BNJ Watson, GM Cook, PC Fineran FEBS letters 588 (3), 414-421, 2014 | 32 | 2014 |
Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis WG Saw, ML Wu, P Ragunathan, G Biuković, AM Lau, J Shin, ... Scientific reports 9 (1), 16759, 2019 | 26 | 2019 |
The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB S Safarian, HK Opel-Reading, D Wu, AR Mehdipour, K Hards, LK Harold, ... Nature Communications 12 (1), 5236, 2021 | 25 | 2021 |