Kiel Hards
Kiel Hards
Microbiology and Immunology, University of Otago
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Cited by
Cited by
Bactericidal mode of action of bedaquiline
K Hards, JR Robson, M Berney, L Shaw, D Bald, A Koul, K Andries, ...
Journal of Antimicrobial Chemotherapy 70 (7), 2028-2037, 2015
Energetics of respiration and oxidative phosphorylation in mycobacteria
GM Cook, K Hards, C Vilchèze, T Hartman, M Berney
Molecular Genetics of Mycobacteria, 389-409, 2014
Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection
NP Kalia, EJ Hasenoehrl, NB Ab Rahman, VH Koh, MLT Ang, DR Sajorda, ...
Proceedings of the National Academy of Sciences 114 (28), 7426-7431, 2017
A soil actinobacterium scavenges atmospheric H2 using two membrane-associated, oxygen-dependent [NiFe] hydrogenases
C Greening, M Berney, K Hards, GM Cook, R Conrad
Proceedings of the National Academy of Sciences 111 (11), 4257-4261, 2014
Persistence of the dominant soil phylum Acidobacteria by trace gas scavenging
C Greening, CR Carere, R Rushton-Green, LK Harold, K Hards, ...
Proceedings of the National Academy of Sciences 112 (33), 10497-10502, 2015
Energetics of pathogenic bacteria and opportunities for drug development
GM Cook, C Greening, K Hards, M Berney
Advances in microbial physiology 65, 1-62, 2014
Mixotrophy drives niche expansion of verrucomicrobial methanotrophs
CR Carere, K Hards, KM Houghton, JF Power, B McDonald, C Collet, ...
The ISME journal 11 (11), 2599-2610, 2017
Oxidative phosphorylation as a target space for tuberculosis: success, caution, and future directions
GM Cook, K Hards, E Dunn, A Heikal, Y Nakatani, C Greening, DC Crick, ...
Tuberculosis and the Tubercle Bacillus, 295-316, 2017
Atmospheric hydrogen scavenging: from enzymes to ecosystems
C Greening, P Constant, K Hards, SE Morales, JG Oakeshott, RJ Russell, ...
Applied and Environmental Microbiology 81 (4), 1190-1199, 2015
Ionophoric effects of the antitubercular drug bedaquiline
K Hards, DGG McMillan, LA Schurig-Briccio, RB Gennis, H Lill, D Bald, ...
Proceedings of the National Academy of Sciences 115 (28), 7326-7331, 2018
Targeting bacterial energetics to produce new antimicrobials
K Hards, GM Cook
Drug Resistance Updates 36, 1-12, 2018
Pyrazolo[1,5-a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis
X Lu, Z Williams, K Hards, J Tang, CY Cheung, HL Aung, B Wang, Z Liu, ...
ACS infectious diseases 5 (2), 239-249, 2018
Essentiality of succinate dehydrogenase in Mycobacterium smegmatis and its role in the generation of the membrane potential under hypoxia
I Pecsi, K Hards, N Ekanayaka, M Berney, T Hartman, WR Jacobs Jr, ...
MBio 5 (4), 10.1128/mbio. 01093-14, 2014
Three different [NiFe] hydrogenases confer metabolic flexibility in the obligate aerobe Mycobacterium smegmatis
M Berney, C Greening, K Hards, D Collins, GM Cook
Environmental microbiology 16 (1), 318-330, 2014
Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering
BM Lee, LK Harold, DV Almeida, L Afriat-Jurnou, HL Aung, BM Forde, ...
PLoS pathogens 16 (2), e1008287, 2020
Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis
BS Lee, K Hards, CA Engelhart, EJ Hasenoehrl, NP Kalia, JS Mackenzie, ...
EMBO Molecular Medicine 13 (1), e13207, 2021
Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death
A Heikal, K Hards, CY Cheung, A Menorca, MSM Timmer, BL Stocker, ...
Journal of Antimicrobial Chemotherapy 71 (10), 2840-2847, 2016
The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB
S Safarian, HK Opel-Reading, D Wu, AR Mehdipour, K Hards, LK Harold, ...
Nature Communications 12 (1), 5236, 2021
The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria
MB McNeil, HG Hampton, KJ Hards, BNJ Watson, GM Cook, PC Fineran
FEBS letters 588 (3), 414-421, 2014
Emerging connections between gut microbiome bioenergetics and chronic metabolic diseases
BA Daisley, D Koenig, K Engelbrecht, L Doney, K Hards, KF Al, G Reid, ...
Cell reports 37 (10), 2021
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