| Metabolism: A Bottleneck in In Vitro Toxicological Test Development: The Report and Recommendations of ECVAM Workshop 54 S Coecke, H Ahr, BJ Blaauboer, S Bremer, S Casati, J Castell, R Combes, ... Alternatives to Laboratory Animals 34 (1), 49-84, 2006 | 213 | 2006 |
| Review of the clinical development of alipogene tiparvovec gene therapy for lipoprotein lipase deficiency D Gaudet, J de Wal, K Tremblay, S Déry, S van Deventer, A Freidig, ... Atherosclerosis Supplements 11 (1), 55-60, 2010 | 148 | 2010 |
| Quantitative profiling of bile acids in biofluids and tissues based on accurate mass high resolution LC-FT-MS: compound class targeting in a metabolomics workflow I Bobeldijk, M Hekman, J de Vries-van der Weij, L Coulier, R Ramaker, ... Journal of Chromatography B 871 (2), 306-313, 2008 | 125 | 2008 |
| Influence of pH and other modifying factors on the distribution behavior of 4-quinolones to solid phases and humic acids studied by “negligible-depletion” SPME− HPLC HC Holten Lützhøft, WHJ Vaes, AP Freidig, B Halling-Sørensen, ... Environmental science & technology 34 (23), 4989-4994, 2000 | 124 | 2000 |
| Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling M Verwei, JA van Burgsteden, CAM Krul, JJM van de Sandt, AP Freidig Toxicology Letters 165 (1), 79-87, 2006 | 103 | 2006 |
| Association between consumption of cruciferous vegetables and condiments and excretion in urine of isothiocyanate mercapturic acids M Vermeulen, R Van den Berg, AP Freidig, PJ Van Bladeren, WHJ Vaes Journal of agricultural and food chemistry 54 (15), 5350-5358, 2006 | 100 | 2006 |
| Nutritional systems biology modeling: from molecular mechanisms to physiology AA de Graaf, AP Freidig, B De Roos, N Jamshidi, M Heinemann, ... PLoS computational biology 5 (11), e1000554, 2009 | 93 | 2009 |
| Use of physiologically based biokinetic (PBBK) modeling to study estragole bioactivation and detoxification in humans as compared with male rats A Punt, A Paini, MG Boersma, AP Freidig, T Delatour, G Scholz, B Schilter, ... Toxicological sciences 110 (2), 255-269, 2009 | 86 | 2009 |
| Estimating impact of humic acid on bioavailability and bioaccumulation of hydrophobic chemicals in guppies using kinetic solid‐phase extraction AP Freidig, EA Garicano, FJM Busser, JLM Hermens Environmental Toxicology and Chemistry: An International Journal 17 (6), 998 …, 1998 | 85 | 1998 |
| A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat A Punt, AP Freidig, T Delatour, G Scholz, MG Boersma, B Schilter, ... Toxicology and applied pharmacology 231 (2), 248-259, 2008 | 83 | 2008 |
| Physiologically-based Kinetic Modelling (PBK Modelling): Meeting the 3Rs Agenda: The Report and Recommendations of ECVAM Workshop 63a MB d'Yvoire, P Prieto, BJ Blaauboer, FY Bois, A Boobis, C Brochot, ... Alternatives to Laboratory Animals 35 (6), 661-671, 2007 | 74 | 2007 |
| Quantitative structure‐property relationships for the chemical reactivity of acrylates and methacrylates AP Freidig, HJM Verhaar, JLM Hermens Environmental Toxicology and Chemistry: An International Journal 18 (6 …, 1999 | 72 | 1999 |
| Comparing the potency of chemicals with multiple modes of action in aquatic toxicology: acute toxicity due to narcosis versus reactive toxicity of acrylic compounds AP Freidig, HJM Verhaar, JLM Hermens Environmental science & technology 33 (17), 3038-3043, 1999 | 69 | 1999 |
| A network biology model of micronutrient related health B Van Ommen, S Fairweather-Tait, A Freidig, A Kardinaal, A Scalbert, ... British Journal of Nutrition 99 (S3), S72-S80, 2008 | 68 | 2008 |
| Predicted serum folate concentrations based on in vitro studies and kinetic modeling are consistent with measured folate concentrations in humans M Verwei, AP Freidig, R Havenaar, JP Groten The Journal of nutrition 136 (12), 3074-3078, 2006 | 60 | 2006 |
| The use of metabolising systems for in vitro testing of endocrine disruptors MN Jacobs, W Janssens, U Bernauer, E Brandon, S Coecke, R Combes, ... Current Drug Metabolism 9 (8), 796-826, 2008 | 57 | 2008 |
| Safety evaluation of chemical mixtures and combinations of chemical and non-chemical stressors D Jonker, AP Freidig, JP Groten, AEM De Hollander, RH Stierum, ... Reviews on environmental health 19 (2), 83-140, 2004 | 56 | 2004 |
| New in vitro dermal absorption database and the prediction of dermal absorption under finite conditions for risk assessment purposes HE Buist, JA van Burgsteden, AP Freidig, WJM Maas, JJM van de Sandt Regulatory Toxicology and Pharmacology 57 (2-3), 200-209, 2010 | 45 | 2010 |
| Narcosis and chemical reactivity QSARs for acute fish toxicity AP Freidig, JLM Hermens Quantitative Structure‐Activity Relationships: An International Journal …, 2000 | 45 | 2000 |
| 1-Octanol/water distribution coefficient of oxolinic acid: influence of pH and its relation to the interaction with dissolved organic carbon HCH Lützhøft, WHJ Vaes, AP Freidig, B Halling-Sørensen, JLM Hermens Chemosphere 40 (7), 711-714, 2000 | 44 | 2000 |
