Zuzana Tothova
Zuzana Tothova
Dana-Farber Cancer Institute, Broad Institute
Verified email at broadinstitute.org - Homepage
Title
Cited by
Cited by
Year
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
JG Doench, N Fusi, M Sullender, M Hegde, EW Vaimberg, KF Donovan, ...
Nature biotechnology 34 (2), 184-191, 2016
19542016
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
Z Tothova, R Kollipara, BJ Huntly, BH Lee, DH Castrillon, DE Cullen, ...
Cell 128 (2), 325-339, 2007
15812007
Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
JG Doench, E Hartenian, DB Graham, Z Tothova, M Hegde, I Smith, ...
Nature biotechnology 32 (12), 1262-1267, 2014
12052014
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
JH Paik, R Kollipara, G Chu, H Ji, Y Xiao, Z Ding, L Miao, Z Tothova, ...
Cell 128 (2), 309-323, 2007
10652007
The retinoblastoma binding protein RBP2 is an H3K4 demethylase
RJ Klose, Q Yan, Z Tothova, K Yamane, H Erdjument-Bromage, P Tempst, ...
Cell 128 (5), 889-900, 2007
4402007
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
K Masutomi, R Possemato, JMY Wong, JL Currier, Z Tothova, JB Manola, ...
Proceedings of the National Academy of Sciences 102 (23), 8222-8227, 2005
4192005
FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system
Z Tothova, DG Gilliland
Cell stem cell 1 (2), 140-152, 2007
3062007
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias
SM Sykes, SW Lane, L Bullinger, D Kalaitzidis, R Yusuf, B Saez, F Ferraro, ...
Cell 146 (5), 697-708, 2011
2522011
FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia
BH Lee, Z Tothova, RL Levine, K Anderson, N Buza-Vidas, DE Cullen, ...
Cancer cell 12 (4), 367-380, 2007
2052007
Mutant calreticulin requires both its mutant C-terminus and the thrombopoietin receptor for oncogenic transformation
S Elf, NS Abdelfattah, E Chen, J Perales-Patón, EA Rosen, A Ko, ...
Cancer discovery 6 (4), 368-381, 2016
1882016
mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion
JY Lee, D Nakada, OH Yilmaz, Z Tothova, NM Joseph, MS Lim, ...
Cell stem cell 7 (5), 593-605, 2010
1882010
Core circadian clock genes regulate leukemia stem cells in AML
RV Puram, MS Kowalczyk, CG de Boer, RK Schneider, PG Miller, ...
Cell 165 (2), 303-316, 2016
1382016
NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a
TL Gu, Z Tothova, B Scheijen, JD Griffin, DG Gilliland, DW Sternberg
Blood 103 (12), 4622-4629, 2004
1252004
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells
KA Hartwell, PG Miller, S Mukherjee, AR Kahn, AL Stewart, DJ Logan, ...
Nature chemical biology 9 (12), 840-848, 2013
1122013
Hemophagocytic syndrome and critical illness: new insights into diagnosis and management
Z Tothova, N Berliner
Journal of intensive care medicine 30 (7), 401-412, 2015
882015
Anaplastic lymphoma kinase-directed therapy in inflammatory myofibroblastic tumors
Z Tothova, AJ Wagner
Current opinion in oncology 24 (4), 409-413, 2012
732012
Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification
MG Cornejo, V Mabialah, SM Sykes, T Khandan, C Lo Celso, CK Lopez, ...
Blood, The Journal of the American Society of Hematology 118 (5), 1264-1273, 2011
642011
Multiplex CRISPR/Cas9-based genome editing in human hematopoietic stem cells models clonal hematopoiesis and myeloid neoplasia
Z Tothova, JM Krill-Burger, KD Popova, CC Landers, QL Sievers, ...
Cell Stem Cell 21 (4), 547-555. e8, 2017
492017
New strategies in myelodysplastic syndromes: application of molecular diagnostics to clinical practice
Z Tothova, DP Steensma, BL Ebert
Clinical Cancer Research 19 (7), 1637-1643, 2013
252013
Intergenerational epigenetic inheritance of cancer susceptibility in mammals
BJ Lesch, Z Tothova, EA Morgan, Z Liao, RT Bronson, BL Ebert, DC Page
Elife 8, e39380, 2019
212019
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