| Mechanism of quinolone action and resistance KJ Aldred, RJ Kerns, N Osheroff Biochemistry 53 (10), 1565-1574, 2014 | 717 | 2014 |
| Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme DA Burden, N Osheroff Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1400 (1-3 …, 1998 | 696 | 1998 |
| Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism (∗) SJ Froelich-Ammon, N Osheroff Journal of Biological Chemistry 270 (37), 21429-21432, 1995 | 661 | 1995 |
| In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction M Berrios, N Osheroff, PA Fisher Proceedings of the National Academy of Sciences 82 (12), 4142-4146, 1985 | 588 | 1985 |
| Etoposide, topoisomerase II and cancer EL Baldwin, N Osheroff Current Medicinal Chemistry-Anti-Cancer Agents 5 (4), 363-372, 2005 | 491 | 2005 |
| Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice JM Fortune, N Osheroff Academic Press 64, 221-253, 2000 | 457 | 2000 |
| DNA topoisomerase II, genotoxicity, and cancer AK McClendon, N Osheroff Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 623 (1 …, 2007 | 390 | 2007 |
| The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing JE Deweese, N Osheroff Nucleic acids research 37 (3), 738-748, 2009 | 386 | 2009 |
| DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA. N Osheroff, ER Shelton, DL Brutlag Journal of Biological Chemistry 258 (15), 9536-9543, 1983 | 352 | 1983 |
| Biochemical basis for the interactions of type I and type II topoisomerases with DNA N Osheroff Pharmacology & therapeutics 41 (1-2), 223-241, 1989 | 349 | 1989 |
| Catalytic function of DNA topoisomerase II N Osheroff, EL Zechiedrich, KC Gale BioEssays 13 (6), 269-275, 1991 | 300 | 1991 |
| DNA topoisomerase II in therapy-related acute promyelocytic leukemia AR Mistry, CA Felix, RJ Whitmarsh, A Mason, A Reiter, B Cassinat, ... New England Journal of Medicine 352 (15), 1529-1538, 2005 | 287 | 2005 |
| Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide N Osheroff Biochemistry 28 (15), 6157-6160, 1989 | 284 | 1989 |
| Merbarone inhibits the catalytic activity of human topoisomerase IIα by blocking DNA cleavage JM Fortune, N Osheroff Journal of Biological Chemistry 273 (28), 17643-17650, 1998 | 278 | 1998 |
| Phosphorylation of DNA topoisomerase II by casein kinase II: modulation of eukaryotic topoisomerase II activity in vitro P Ackerman, CV Glover, N Osheroff Proceedings of the National Academy of Sciences 82 (10), 3164-3168, 1985 | 278 | 1985 |
| When good enzymes go bad: conversion of topoisomerase II to a cellular toxin by antineoplastic drugs AH Corbett, N Osheroff Chemical Research in Toxicology 6 (5), 585-597, 1993 | 275 | 1993 |
| Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers. EL Zechiedrich, N Osheroff The EMBO journal 9 (13), 4555-4562, 1990 | 262 | 1990 |
| Eukaryotic topoisomerase II. Characterization of enzyme turnover. N Osheroff Journal of Biological Chemistry 261 (21), 9944-9950, 1986 | 244 | 1986 |
| Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes AM Wilstermann, N Osheroff Current topics in medicinal chemistry 3 (3), 321-338, 2003 | 211 | 2003 |
| Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage MJ Robinson, BA Martin, TD Gootz, PR McGuirk, M Moynihan, JA Sutcliffe, ... Journal of Biological Chemistry 266 (22), 14585-14592, 1991 | 191 | 1991 |
Anita H CorbettProfessor of Biochemistry, Emory University School of MedicineVerified email at emory.edu
