Erik van den Akker
Erik van den Akker
Assistant Professor of Computational Biology; Leiden University Medical Center
Verified email at - Homepage
Cited by
Cited by
Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
J Deelen, M Beekman, HW Uh, Q Helmer, M Kuningas, L Christiansen, ...
Aging cell 10 (4), 686-698, 2011
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
J Deelen, M Beekman, HW Uh, L Broer, KL Ayers, Q Tan, Y Kamatani, ...
Human molecular genetics 23 (16), 4420-4432, 2014
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array
RC Slieker, SD Bos, JJ Goeman, JVMG Bovée, RP Talens, ...
Epigenetics & chromatin 6 (1), 1-12, 2013
Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study
M Beekman, H Blanché, M Perola, A Hervonen, V Bezrukov, E Sikora, ...
Aging cell 12 (2), 184-193, 2013
The trans-ancestral genomic architecture of glycemic traits
J Chen, CN Spracklen, G Marenne, A Varshney, LJ Corbin, J Luan, ...
Nature genetics 53 (6), 840-860, 2021
A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
J Deelen, J Kettunen, K Fischer, A van der Spek, S Trompet, ...
Nature communications 10 (1), 3346, 2019
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
J Deelen, HW Uh, R Monajemi, D van Heemst, PE Thijssen, S Böhringer, ...
Age 35, 235-249, 2013
Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis
N Bomer, W den Hollander, YFM Ramos, SD Bos, R van der Breggen, ...
Annals of the rheumatic diseases 74 (8), 1571-1579, 2015
Genomics of human longevity
PE Slagboom, M Beekman, WM Passtoors, J Deelen, AAM Vaarhorst, ...
Philosophical Transactions of the Royal Society B: Biological Sciences 366 …, 2011
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the …
SJ Van Der Lee, OJ Conway, I Jansen, MM Carrasquillo, L Kleineidam, ...
Acta neuropathologica 138, 237-250, 2019
Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice
F Rusli, J Deelen, E Andriyani, MV Boekschoten, C Lute, ...
Scientific reports 6 (1), 1-16, 2016
Cerebral small vessel disease genomics and its implications across the lifespan
M Sargurupremraj, H Suzuki, X Jian, C Sarnowski, TE Evans, JC Bis, ...
Nature communications 11 (1), 6285, 2020
Human plasma N-glycosylation as analyzed by matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance-MS associates with markers of inflammation and …
KR Reiding, LR Ruhaak, HW Uh, S El Bouhaddani, EB van den Akker, ...
Molecular & Cellular Proteomics 16 (2), 228-242, 2017
Genome-wide association study on immunoglobulin G glycosylation patterns
A Wahl, E Van den Akker, L Klaric, J Štambuk, E Benedetti, R Plomp, ...
Frontiers in immunology 9, 277, 2018
Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R
WM Passtoors, JM Boer, JJ Goeman, EB van den Akker, J Deelen, ...
PLoS one 7 (1), e27759, 2012
Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas
J Liu, L Lahousse, MG Nivard, M Bot, L Chen, JB van Klinken, CS Thesing, ...
Nature medicine 26 (1), 110-117, 2020
Meta‐analysis on blood transcriptomic studies identifies consistently coexpressed protein–protein interaction modules as robust markers of human aging
EB van den Akker, WM Passtoors, R Jansen, EW van Zwet, JJ Goeman, ...
Aging cell 13 (2), 216-225, 2014
Integrating metabolomics, genomics, and disease pathways in age-related macular degeneration: the EYE-RISK consortium
IE Acar, L Lores-Motta, JM Colijn, MA Meester-Smoor, T Verzijden, ...
Ophthalmology 127 (12), 1693-1709, 2020
Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures for classifying breast cancer metastasis
E Akker, B Verbruggen, B Heijmans, M Beekman, J Kok, E Slagboom, ...
Journal of Integrative Bioinformatics 8 (2), 222-238, 2011
Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile
F Vrieling, K Ronacher, L Kleynhans, E Van Den Akker, G Walzl, ...
EBioMedicine 32, 192-200, 2018
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