Erik van den Akker
Erik van den Akker
Molecular Epidemiology Leiden University Medical Centre
Verified email at - Homepage
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Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
J Deelen, M Beekman, HW Uh, Q Helmer, M Kuningas, L Christiansen, ...
Aging cell 10 (4), 686-698, 2011
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
J Deelen, M Beekman, HW Uh, L Broer, KL Ayers, Q Tan, Y Kamatani, ...
Human molecular genetics 23 (16), 4420-4432, 2014
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array
RC Slieker, SD Bos, JJ Goeman, JVMG Bovée, RP Talens, ...
Epigenetics & chromatin 6 (1), 1-12, 2013
Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study
M Beekman, H Blanché, M Perola, A Hervonen, V Bezrukov, E Sikora, ...
Aging cell 12 (2), 184-193, 2013
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
J Deelen, HW Uh, R Monajemi, D van Heemst, PE Thijssen, S Böhringer, ...
Age 35 (1), 235-249, 2013
A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
J Deelen, J Kettunen, K Fischer, A van der Spek, S Trompet, ...
Nature communications 10 (1), 1-8, 2019
Genomics of human longevity
PE Slagboom, M Beekman, WM Passtoors, J Deelen, AAM Vaarhorst, ...
Philosophical Transactions of the Royal Society B: Biological Sciences 366 …, 2011
Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis
N Bomer, W den Hollander, YFM Ramos, SD Bos, R van der Breggen, ...
Annals of the rheumatic diseases 74 (8), 1571-1579, 2015
Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R
WM Passtoors, JM Boer, JJ Goeman, EB van den Akker, J Deelen, ...
PLoS one 7 (1), e27759, 2012
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
SJ Van Der Lee, OJ Conway, I Jansen, MM Carrasquillo, L Kleineidam, ...
Acta neuropathologica 138 (2), 237-250, 2019
Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice
F Rusli, J Deelen, E Andriyani, MV Boekschoten, C Lute, ...
Scientific reports 6 (1), 1-16, 2016
Human plasma N-glycosylation as analyzed by matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance-MS associates with markers of inflammation and …
KR Reiding, LR Ruhaak, HW Uh, S El Bouhaddani, EB van den Akker, ...
Molecular & Cellular Proteomics 16 (2), 228-242, 2017
Genome-wide association study on immunoglobulin G glycosylation patterns
A Wahl, E van den Akker, L Klaric, J Štambuk, E Benedetti, R Plomp, ...
Frontiers in immunology 9, 277, 2018
Meta‐analysis on blood transcriptomic studies identifies consistently coexpressed protein–protein interaction modules as robust markers of human aging
EB van den Akker, WM Passtoors, R Jansen, EW van Zwet, JJ Goeman, ...
Aging cell 13 (2), 216-225, 2014
Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures for classifying breast cancer metastasis
E van den Akker, B Verbruggen, B Heijmans, M Beekman, J Kok, ...
Journal of integrative bioinformatics 8 (2), 222-238, 2011
Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2
EB van den Akker, SJ Pitts, J Deelen, MH Moed, S Potluri, J van Rooij, ...
Blood, The Journal of the American Society of Hematology 127 (11), 1512-1515, 2016
Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs
K Ye, M Beekman, EW Lameijer, Y Zhang, MH Moed, EB van den Akker, ...
Twin Research and Human Genetics 16 (6), 1026-1032, 2013
IgG glycosylation and DNA methylation are interconnected with smoking
A Wahl, S Kasela, E Carnero-Montoro, M van Iterson, J Štambuk, ...
Biochimica et Biophysica Acta (BBA)-General Subjects 1862 (3), 637-648, 2018
Metabolic effects of a 13-weeks lifestyle intervention in older adults: The Growing Old Together Study
O van de Rest, BAM Schutte, J Deelen, SAM Stassen, EB van den Akker, ...
Aging (Albany NY) 8 (1), 111, 2016
IL7R gene expression network associates with human healthy ageing
WM Passtoors, EB van den Akker, J Deelen, AB Maier, ...
Immunity & ageing 12 (1), 1-9, 2015
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