| Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited J Deelen, M Beekman, HW Uh, Q Helmer, M Kuningas, L Christiansen, ... Aging cell 10 (4), 686-698, 2011 | 315 | 2011 |
| Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age J Deelen, M Beekman, HW Uh, L Broer, KL Ayers, Q Tan, Y Kamatani, ... Human molecular genetics 23 (16), 4420-4432, 2014 | 261 | 2014 |
| Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array RC Slieker, SD Bos, JJ Goeman, JVMG Bovée, RP Talens, ... Epigenetics & chromatin 6 (1), 1-12, 2013 | 248 | 2013 |
| Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study M Beekman, H Blanché, M Perola, A Hervonen, V Bezrukov, E Sikora, ... Aging cell 12 (2), 184-193, 2013 | 194 | 2013 |
| The trans-ancestral genomic architecture of glycemic traits J Chen, CN Spracklen, G Marenne, A Varshney, LJ Corbin, J Luan, ... Nature genetics 53 (6), 840-860, 2021 | 186 | 2021 |
| A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals J Deelen, J Kettunen, K Fischer, A van der Spek, S Trompet, ... Nature communications 10 (1), 3346, 2019 | 171 | 2019 |
| Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways J Deelen, HW Uh, R Monajemi, D van Heemst, PE Thijssen, S Böhringer, ... Age 35, 235-249, 2013 | 143 | 2013 |
| Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis N Bomer, W den Hollander, YFM Ramos, SD Bos, R van der Breggen, ... Annals of the rheumatic diseases 74 (8), 1571-1579, 2015 | 100 | 2015 |
| Genomics of human longevity PE Slagboom, M Beekman, WM Passtoors, J Deelen, AAM Vaarhorst, ... Philosophical Transactions of the Royal Society B: Biological Sciences 366 …, 2011 | 98 | 2011 |
| A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the … SJ Van Der Lee, OJ Conway, I Jansen, MM Carrasquillo, L Kleineidam, ... Acta neuropathologica 138, 237-250, 2019 | 90 | 2019 |
| Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice F Rusli, J Deelen, E Andriyani, MV Boekschoten, C Lute, ... Scientific reports 6 (1), 1-16, 2016 | 89 | 2016 |
| Cerebral small vessel disease genomics and its implications across the lifespan M Sargurupremraj, H Suzuki, X Jian, C Sarnowski, TE Evans, JC Bis, ... Nature communications 11 (1), 6285, 2020 | 75 | 2020 |
| Human plasma N-glycosylation as analyzed by matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance-MS associates with markers of inflammation and … KR Reiding, LR Ruhaak, HW Uh, S El Bouhaddani, EB van den Akker, ... Molecular & Cellular Proteomics 16 (2), 228-242, 2017 | 71 | 2017 |
| Genome-wide association study on immunoglobulin G glycosylation patterns A Wahl, E Van den Akker, L Klaric, J Štambuk, E Benedetti, R Plomp, ... Frontiers in immunology 9, 277, 2018 | 68 | 2018 |
| Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R WM Passtoors, JM Boer, JJ Goeman, EB van den Akker, J Deelen, ... PLoS one 7 (1), e27759, 2012 | 64 | 2012 |
| Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas J Liu, L Lahousse, MG Nivard, M Bot, L Chen, JB van Klinken, CS Thesing, ... Nature medicine 26 (1), 110-117, 2020 | 47 | 2020 |
| Meta‐analysis on blood transcriptomic studies identifies consistently coexpressed protein–protein interaction modules as robust markers of human aging EB van den Akker, WM Passtoors, R Jansen, EW van Zwet, JJ Goeman, ... Aging cell 13 (2), 216-225, 2014 | 47 | 2014 |
| Integrating metabolomics, genomics, and disease pathways in age-related macular degeneration: the EYE-RISK consortium IE Acar, L Lores-Motta, JM Colijn, MA Meester-Smoor, T Verzijden, ... Ophthalmology 127 (12), 1693-1709, 2020 | 46 | 2020 |
| Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures for classifying breast cancer metastasis E Akker, B Verbruggen, B Heijmans, M Beekman, J Kok, E Slagboom, ... Journal of Integrative Bioinformatics 8 (2), 222-238, 2011 | 45 | 2011 |
| Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile F Vrieling, K Ronacher, L Kleynhans, E Van Den Akker, G Walzl, ... EBioMedicine 32, 192-200, 2018 | 44 | 2018 |
P. Eline SlagboomProfessor Molecular Epidemiology, Leiden University Medical CenterVerified email at lumc.nl
