Bas Heijmans
Bas Heijmans
Leiden University Medical Center, The Netherlands
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Persistent epigenetic differences associated with prenatal exposure to famine in humans
BT Heijmans, EW Tobi, AD Stein, H Putter, GJ Blauw, ES Susser, ...
Proceedings of the National Academy of Sciences 105 (44), 17046-17049, 2008
28952008
DNA methylation differences after exposure to prenatal famine are common and timing-and sex-specific
EW Tobi, LH Lumey, RP Talens, D Kremer, H Putter, AD Stein, ...
Human molecular genetics 18 (21), 4046-4053, 2009
10892009
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
S Wahl, A Drong, B Lehne, M Loh, WR Scott, S Kunze, PC Tsai, JS Ried, ...
Nature 541 (7635), 81-86, 2017
5442017
Periconceptional maternal folic acid use of 400 µg per day is related to increased methylation of the IGF2 gene in the very young child
RP Steegers-Theunissen, SA Obermann-Borst, D Kremer, J Lindemans, ...
PloS one 4 (11), e7845, 2009
4712009
DNA methylation signatures link prenatal famine exposure to growth and metabolism
EW Tobi, JJ Goeman, R Monajemi, H Gu, H Putter, Y Zhang, RC Slieker, ...
Nature communications 5 (1), 1-14, 2014
4462014
Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology
RP Talens, DI Boomsma, EW Tobi, D Kremer, JW Jukema, G Willemsen, ...
The FASEB Journal 24 (9), 3135-3144, 2010
3282010
Reduced insulin/IGF‐1 signalling and human longevity
D Van Heemst, M Beekman, SP Mooijaart, BT Heijmans, BW Brandt, ...
Aging cell 4 (2), 79-85, 2005
3272005
From promises to practical strategies in epigenetic epidemiology
J Mill, BT Heijmans
Nature Reviews Genetics 14 (8), 585-594, 2013
3212013
Disease variants alter transcription factor levels and methylation of their binding sites
MJ Bonder, R Luijk, D Zhernakova, M Moed, P Deelen, M Vermaat, ...
Nature genetics 49 (1), 131–138, 2017
2942017
Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis
U Vősa, A Claringbould, HJ Westra, MJ Bonder, P Deelen, B Zeng, ...
BioRxiv, 447367, 2018
2902018
Identification of context-dependent expression quantitative trait loci in whole blood
DV Zhernakova, P Deelen, M Vermaat, M Van Iterson, M Van Galen, ...
Nature genetics 49 (1), 139-145, 2017
2882017
Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
J Deelen, M Beekman, HW Uh, Q Helmer, M Kuningas, L Christiansen, ...
Aging cell 10 (4), 686-698, 2011
2862011
Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus
BT Heijmans, D Kremer, EW Tobi, DI Boomsma, PE Slagboom
Human molecular genetics 16 (5), 547-554, 2007
2842007
Epigenetic variation during the adult lifespan: cross‐sectional and longitudinal data on monozygotic twin pairs
RP Talens, K Christensen, H Putter, G Willemsen, L Christiansen, ...
Aging cell 11 (4), 694-703, 2012
2832012
Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single‐nucleotide polymorphisms in genes coding for folate pathway enzymes
JAM Wessels, JK de Vries‐Bouwstra, BT Heijmans, PE Slagboom, ...
Arthritis & Rheumatism 54 (4), 1087-1095, 2006
2722006
Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study
RGJ Westendorp, D Van Heemst, MP Rozing, M Frölich, SP Mooijaart, ...
Journal of the American Geriatrics Society 57 (9), 1634-1637, 2009
2692009
The epigenome: archive of the prenatal environment
BT Heijmans, EW Tobi, LH Lumey, PE Slagboom
Epigenetics 4 (8), 526-531, 2009
2632009
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
N Kato, M Loh, F Takeuchi, N Verweij, X Wang, W Zhang, TN Kelly, ...
Nature genetics 47 (11), 1282-1293, 2015
2482015
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
J Deelen, M Beekman, HW Uh, L Broer, KL Ayers, Q Tan, Y Kamatani, ...
Human molecular genetics 23 (16), 4420-4432, 2014
2302014
Genetic and environmental influences interact with age and sex in shaping the human methylome
J Van Dongen, MG Nivard, G Willemsen, JJ Hottenga, Q Helmer, ...
Nature communications 7 (1), 1-13, 2016
2192016
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Artikelen 1–20