| Persistent epigenetic differences associated with prenatal exposure to famine in humans BT Heijmans, EW Tobi, AD Stein, H Putter, GJ Blauw, ES Susser, ... Proceedings of the National Academy of Sciences 105 (44), 17046-17049, 2008 | 3252 | 2008 |
| DNA methylation differences after exposure to prenatal famine are common and timing-and sex-specific EW Tobi, LH Lumey, RP Talens, D Kremer, H Putter, AD Stein, ... Human molecular genetics 18 (21), 4046-4053, 2009 | 1209 | 2009 |
| Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression U Vősa, A Claringbould, HJ Westra, MJ Bonder, P Deelen, B Zeng, ... Nature genetics 53 (9), 1300-1310, 2021 | 779* | 2021 |
| Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity S Wahl, A Drong, B Lehne, M Loh, WR Scott, S Kunze, PC Tsai, JS Ried, ... Nature 541 (7635), 81-86, 2017 | 743 | 2017 |
| DNA methylation signatures link prenatal famine exposure to growth and metabolism EW Tobi, JJ Goeman, R Monajemi, H Gu, H Putter, Y Zhang, RC Slieker, ... Nature communications 5 (1), 5592, 2014 | 537 | 2014 |
| Periconceptional maternal folic acid use of 400 µg per day is related to increased methylation of the IGF2 gene in the very young child RP Steegers-Theunissen, SA Obermann-Borst, D Kremer, J Lindemans, ... PloS one 4 (11), e7845, 2009 | 518 | 2009 |
| DNA methylation aging clocks: challenges and recommendations CG Bell, R Lowe, PD Adams, AA Baccarelli, S Beck, JT Bell, ... Genome biology 20, 1-24, 2019 | 478 | 2019 |
| Disease variants alter transcription factor levels and methylation of their binding sites MJ Bonder, R Luijk, D Zhernakova, M Moed, P Deelen, M Vermaat, ... Nature genetics 49 (1), 131–138, 2017 | 399 | 2017 |
| Identification of context-dependent expression quantitative trait loci in whole blood DV Zhernakova, P Deelen, M Vermaat, M Van Iterson, M Van Galen, ... Nature genetics 49 (1), 139-145, 2017 | 395 | 2017 |
| From promises to practical strategies in epigenetic epidemiology J Mill, BT Heijmans Nature Reviews Genetics 14 (8), 585-594, 2013 | 360 | 2013 |
| Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology RP Talens, DI Boomsma, EW Tobi, D Kremer, JW Jukema, G Willemsen, ... The FASEB Journal 24 (9), 3135-3144, 2010 | 355 | 2010 |
| Epigenetic variation during the adult lifespan: cross‐sectional and longitudinal data on monozygotic twin pairs RP Talens, K Christensen, H Putter, G Willemsen, L Christiansen, ... Aging cell 11 (4), 694-703, 2012 | 348 | 2012 |
| Reduced insulin/IGF‐1 signalling and human longevity D Van Heemst, M Beekman, SP Mooijaart, BT Heijmans, BW Brandt, ... Aging cell 4 (2), 79-85, 2005 | 342 | 2005 |
| Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation N Kato, M Loh, F Takeuchi, N Verweij, X Wang, W Zhang, TN Kelly, ... Nature genetics 47 (11), 1282-1293, 2015 | 327 | 2015 |
| Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited J Deelen, M Beekman, HW Uh, Q Helmer, M Kuningas, L Christiansen, ... Aging cell 10 (4), 686-698, 2011 | 315 | 2011 |
| Genetic and environmental influences interact with age and sex in shaping the human methylome J Van Dongen, MG Nivard, G Willemsen, JJ Hottenga, Q Helmer, ... Nature communications 7 (1), 11115, 2016 | 303 | 2016 |
| Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus BT Heijmans, D Kremer, EW Tobi, DI Boomsma, PE Slagboom Human molecular genetics 16 (5), 547-554, 2007 | 292 | 2007 |
| Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study RGJ Westendorp, D Van Heemst, MP Rozing, M Frölich, SP Mooijaart, ... Journal of the American Geriatrics Society 57 (9), 1634-1637, 2009 | 290 | 2009 |
| Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single‐nucleotide polymorphisms in genes coding for folate pathway enzymes JAM Wessels, JK de Vries‐Bouwstra, BT Heijmans, PE Slagboom, ... Arthritis & Rheumatism 54 (4), 1087-1095, 2006 | 281 | 2006 |
| The epigenome: archive of the prenatal environment BT Heijmans, EW Tobi, LH Lumey, PE Slagboom Epigenetics 4 (8), 526-531, 2009 | 279 | 2009 |
