John J. Renger, Ph.D.
John J. Renger, Ph.D.
Cerevel Therapeutics
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Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions
BA Stewart, HL Atwood, JJ Renger, J Wang, CF Wu
Journal of Comparative Physiology A 175, 179-191, 1994
Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl …
CD Cox, MJ Breslin, DB Whitman, JD Schreier, GB McGaughey, ...
Journal of medicinal chemistry 53 (14), 5320-5332, 2010
Promotion of sleep by suvorexant—a novel dual orexin receptor antagonist
CJ Winrow, AL Gotter, CD Cox, SM Doran, PL Tannenbaum, MJ Breslin, ...
Journal of neurogenetics 25 (1-2), 52-61, 2011
A developmental switch in neurotransmitter flux enhances synaptic efficacy by affecting AMPA receptor activation
JJ Renger, C Egles, G Liu
Neuron 29 (2), 469-484, 2001
Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of ITwindow
FM Dreyfus, A Tscherter, AC Errington, JJ Renger, HS Shin, VN Uebele, ...
Journal of Neuroscience 30 (1), 99-109, 2010
Essential thalamic contribution to slow waves of natural sleep
F David, JT Schmiedt, HL Taylor, G Orban, G Di Giovanni, VN Uebele, ...
Journal of Neuroscience 33 (50), 19599-19610, 2013
Internalized tau oligomers cause neurodegeneration by inducing accumulation of pathogenic tau in human neurons derived from induced pluripotent stem cells
M Usenovic, S Niroomand, RE Drolet, L Yao, RC Gaspar, NG Hatcher, ...
Journal of Neuroscience 35 (42), 14234-14250, 2015
Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses
Z Huang, R Lujan, I Kadurin, VN Uebele, JJ Renger, AC Dolphin, ...
Nature neuroscience 14 (4), 478-486, 2011
International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology
AL Gotter, AL Webber, PJ Coleman, JJ Renger, CJ Winrow
Pharmacological reviews 64 (3), 389-420, 2012
Presynaptic Cav3. 2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons
MO Jacus, VN Uebele, JJ Renger, SM Todorovic
Journal of Neuroscience 32 (27), 9374-9382, 2012
A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid
MJ Savage, J Kalinina, A Wolfe, K Tugusheva, R Korn, T Cash-Mason, ...
Journal of Neuroscience 34 (8), 2884-2897, 2014
Discovery and development of orexin receptor antagonists as therapeutics for insomnia
CJ Winrow, JJ Renger
British journal of pharmacology 171 (2), 283-293, 2014
Pharmacological characterization of MK-6096–a dual orexin receptor antagonist for insomnia
CJ Winrow, AL Gotter, CD Cox, PL Tannenbaum, SL Garson, SM Doran, ...
Neuropharmacology 62 (2), 978-987, 2012
Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca2+ Channel Antagonist
WD Shipe, JC Barrow, ZQ Yang, CW Lindsley, FV Yang, KAS Schlegel, ...
Journal of medicinal chemistry 51 (13), 3692-3695, 2008
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors
J Yin, K Babaoglu, CA Brautigam, L Clark, Z Shao, TH Scheuermann, ...
Nature Structural & Molecular Biology 23 (4), 293-299, 2016
Calcineurin signaling mediates activity-dependent relocation of the axon initial segment
MD Evans, RP Sammons, S Lebron, AS Dumitrescu, TBK Watkins, ...
Journal of Neuroscience 33 (16), 6950-6963, 2013
Concomitant alterations of physiological and developmental plasticity in Drosophila CaM kinase II-inhibited synapses
J Wang, JI Renger, LC Griffith, RJ Greenspan, CF Wu
Neuron 13 (6), 1373-1384, 1994
Discovery of [(2R,5R)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin …
PJ Coleman, JD Schreier, CD Cox, MJ Breslin, DB Whitman, MJ Bogusky, ...
ChemMedChem 7 (3), 415-424, 2012
In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice
RL Kraus, Y Li, Y Gregan, AL Gotter, VN Uebele, SV Fox, SM Doran, ...
Journal of Pharmacology and Experimental Therapeutics 335 (2), 409-417, 2010
Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure
CJ Winrow, KQ Tanis, DR Reiss, AM Rigby, JM Uslaner, VN Uebele, ...
Neuropharmacology 58 (1), 185-194, 2010
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