Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer V Abkevich, KM Timms, BT Hennessy, J Potter, MS Carey, LA Meyer, ... British journal of cancer 107 (10), 1776-1782, 2012 | 737 | 2012 |
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, ... Science 370 (6521), eabe9403, 2020 | 620 | 2020 |
The role of metabolic activation in drug-induced hepatotoxicity BK Park, NR Kitteringham, JL Maggs, M Pirmohamed, DP Williams Annu. Rev. Pharmacol. Toxicol. 45, 177-202, 2005 | 591 | 2005 |
Managing the challenge of chemically reactive metabolites in drug development BK Park, A Boobis, S Clarke, CEP Goldring, D Jones, JG Kenna, ... Nature Reviews Drug Discovery 10 (4), 292-306, 2011 | 483 | 2011 |
The UK‐PBC risk scores: derivation and validation of a scoring system for long‐term prediction of end‐stage liver disease in primary biliary cholangitis M Carbone, SJ Sharp, S Flack, D Paximadas, K Spiess, C Adgey, ... Hepatology 63 (3), 930-950, 2016 | 374 | 2016 |
Metabolism and bioactivation of clozapine by human liver in vitro. M Pirmohamed, D Williams, S Madden, E Templeton, BK Park Journal of Pharmacology and Experimental Therapeutics 272 (3), 984-990, 1995 | 341 | 1995 |
Reproducing human and cross-species drug toxicities using a Liver-Chip KJ Jang, MA Otieno, J Ronxhi, HK Lim, L Ewart, KR Kodella, ... Science translational medicine 11 (517), eaax5516, 2019 | 329 | 2019 |
Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: a multicenter study CC Bell, ACA Dankers, VM Lauschke, R Sison-Young, R Jenkins, ... Toxicological Sciences 162 (2), 655-666, 2018 | 278 | 2018 |
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury WR Proctor, AJ Foster, J Vogt, C Summers, B Middleton, MA Pilling, ... Archives of toxicology 91, 2849-2863, 2017 | 274 | 2017 |
High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo DJ Antoine, DP Williams, A Kipar, RE Jenkins, SL Regan, JG Sathish, ... Toxicological sciences 112 (2), 521-531, 2009 | 260 | 2009 |
Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice CEP Goldring, NR Kitteringham, R Elsby, LE Randle, YN Clement, ... Hepatology 39 (5), 1267-1276, 2004 | 242 | 2004 |
PAC-Man study collaboration. Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised … S Harvey, DA Harrison, M Singer, J Ashcroft, CM Jones, D Elbourne, ... Lancet 366 (9484), 472-477, 2005 | 219 | 2005 |
Obstetric skills drills: evaluation of teaching methods L Birch, N Jones, PM Doyle, P Green, A McLaughlin, C Champney, ... Nurse education today 27 (8), 915-922, 2007 | 218 | 2007 |
Acyl glucuronides: the good, the bad and the ugly SL Regan, JL Maggs, TG Hammond, C Lambert, DP Williams, BK Park Biopharmaceutics & drug disposition 31 (7), 367-395, 2010 | 197 | 2010 |
Characterisation of the toxic metabolite (s) of naphthalene AS Wilson, CD Davis, DP Williams, AR Buckpitt, M Pirmohamed, BK Park Toxicology 114 (3), 233-242, 1996 | 197 | 1996 |
Synergistic interactions between commonly used food additives in a developmental neurotoxicity test K Lau, WG McLean, DP Williams, CV Howard Toxicological Sciences 90 (1), 178-187, 2006 | 196 | 2006 |
Sarcopenia is a predictor of outcomes in very elderly patients undergoing emergency surgery Y Du, CJ Karvellas, V Baracos, DC Williams, RG Khadaroo, ESA Group Surgery 156 (3), 521-527, 2014 | 183 | 2014 |
Role of reactive metabolites in drug-induced hepatotoxicity A Srivastava, JL Maggs, DJ Antoine, DP Williams, DA Smith, BK Park Adverse drug reactions, 165-194, 2010 | 173 | 2010 |
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models RJ Weaver, EA Blomme, AE Chadwick, IM Copple, HHJ Gerets, ... Nature Reviews Drug Discovery 19 (2), 131-148, 2020 | 172 | 2020 |
Induction of metabolism-dependent and-independent neutrophil apoptosis by clozapine DP Williams, M Pirmohamed, DJ Naisbitt, JP Uetrecht, BK Park Molecular pharmacology 58 (1), 207-216, 2000 | 170 | 2000 |