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Dr Dominic Williams
Dr Dominic Williams
Astrazeneca
Verified email at liv.ac.uk - Homepage
Title
Cited by
Cited by
Year
Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer
V Abkevich, KM Timms, BT Hennessy, J Potter, MS Carey, LA Meyer, ...
British journal of cancer 107 (10), 1776-1782, 2012
7282012
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, ...
Science 370 (6521), eabe9403, 2020
5982020
The role of metabolic activation in drug-induced hepatotoxicity
BK Park, NR Kitteringham, JL Maggs, M Pirmohamed, DP Williams
Annu. Rev. Pharmacol. Toxicol. 45, 177-202, 2005
5882005
Managing the challenge of chemically reactive metabolites in drug development
BK Park, A Boobis, S Clarke, CEP Goldring, D Jones, JG Kenna, ...
Nature Reviews Drug Discovery 10 (4), 292-306, 2011
4782011
The UK‐PBC risk scores: derivation and validation of a scoring system for long‐term prediction of end‐stage liver disease in primary biliary cholangitis
M Carbone, SJ Sharp, S Flack, D Paximadas, K Spiess, C Adgey, ...
Hepatology 63 (3), 930-950, 2016
3702016
Metabolism and bioactivation of clozapine by human liver in vitro.
M Pirmohamed, D Williams, S Madden, E Templeton, BK Park
Journal of Pharmacology and Experimental Therapeutics 272 (3), 984-990, 1995
3391995
Reproducing human and cross-species drug toxicities using a Liver-Chip
KJ Jang, MA Otieno, J Ronxhi, HK Lim, L Ewart, KR Kodella, ...
Science translational medicine 11 (517), eaax5516, 2019
3192019
Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: a multicenter study
CC Bell, ACA Dankers, VM Lauschke, R Sison-Young, R Jenkins, ...
Toxicological Sciences 162 (2), 655-666, 2018
2712018
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
WR Proctor, AJ Foster, J Vogt, C Summers, B Middleton, MA Pilling, ...
Archives of toxicology 91, 2849-2863, 2017
2652017
High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo
DJ Antoine, DP Williams, A Kipar, RE Jenkins, SL Regan, JG Sathish, ...
Toxicological sciences 112 (2), 521-531, 2009
2572009
Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice
CEP Goldring, NR Kitteringham, R Elsby, LE Randle, YN Clement, ...
Hepatology 39 (5), 1267-1276, 2004
2412004
PAC-Man study collaboration. Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised …
S Harvey, DA Harrison, M Singer, J Ashcroft, CM Jones, D Elbourne, ...
Lancet 366 (9484), 472-477, 2005
2192005
Obstetric skills drills: evaluation of teaching methods
L Birch, N Jones, PM Doyle, P Green, A McLaughlin, C Champney, ...
Nurse education today 27 (8), 915-922, 2007
2172007
Acyl glucuronides: the good, the bad and the ugly
SL Regan, JL Maggs, TG Hammond, C Lambert, DP Williams, BK Park
Biopharmaceutics & drug disposition 31 (7), 367-395, 2010
1952010
Synergistic interactions between commonly used food additives in a developmental neurotoxicity test
K Lau, WG McLean, DP Williams, CV Howard
Toxicological Sciences 90 (1), 178-187, 2006
1952006
Characterisation of the toxic metabolite (s) of naphthalene
AS Wilson, CD Davis, DP Williams, AR Buckpitt, M Pirmohamed, BK Park
Toxicology 114 (3), 233-242, 1996
1951996
Characterisation of the toxic metabolite (s) of naphthalene
AS Wilson, CD Davis, DP Williams, AR Buckpitt, M Pirmohamed, BK Park
Toxicology 114 (3), 233-242, 1996
1951996
Sarcopenia is a predictor of outcomes in very elderly patients undergoing emergency surgery
Y Du, CJ Karvellas, V Baracos, DC Williams, RG Khadaroo, ESA Group
Surgery 156 (3), 521-527, 2014
1792014
Role of reactive metabolites in drug-induced hepatotoxicity
A Srivastava, JL Maggs, DJ Antoine, DP Williams, DA Smith, BK Park
Adverse drug reactions, 165-194, 2010
1722010
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
RJ Weaver, EA Blomme, AE Chadwick, IM Copple, HHJ Gerets, ...
Nature Reviews Drug Discovery 19 (2), 131-148, 2020
1682020
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