C. Arnold Spek
C. Arnold Spek
Associate Professor
Verified email at amc.uva.nl
TitleCited byYear
Repression of smoothened by patched-dependent (pro-) vitamin D3 secretion
MF Bijlsma, CA Spek, D Zivkovic, S van de Water, F Rezaee, ...
PLoS biology 4 (8), e232, 2006
3272006
Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses
PI Bonta, CM van Tiel, M Vos, TWH Pols, JV van Thienen, V Ferreira, ...
Arteriosclerosis, thrombosis, and vascular biology 26 (10), 2288-2288, 2006
2172006
Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways
E Eldering, CA Spek, HL Aberson, A Grummels, IA Derks, AF de Vos, ...
Nucleic acids research 31 (23), e153-e153, 2003
2172003
The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation
RF Franco, E de Jonge, PEP Dekkers, JJ Timmerman, CA Spek, ...
Blood 96 (2), 554-559, 2000
2062000
Factor Xa: at the crossroads between coagulation and signaling in physiology and disease
K Borensztajn, MP Peppelenbosch, CA Spek
Trends in molecular medicine 14 (10), 429-440, 2008
1532008
Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers
NA Maris, AF De Vos, MC Dessing, CA Spek, R Lutter, HM Jansen, ...
American journal of respiratory and critical care medicine 172 (7), 878-884, 2005
1392005
Alternatively spliced tissue factor induces angiogenesis through integrin ligation
YW Van den Berg, LG Van Den Hengel, HR Myers, O Ayachi, ...
Proceedings of the National Academy of Sciences 106 (46), 19497-19502, 2009
1362009
Genotypic variation in the promoter region of the protein C gene is associated with plasma protein C levels and thrombotic risk
CA Spek, T Koster, FR Rosendaal, RM Bertina, PH Reitsma
Arteriosclerosis, thrombosis, and vascular biology 15 (2), 214-218, 1995
1301995
The pleiotropic effects of tissue factor: a possible role for factor VIIa-induced intracellular signalling?
HH Versteeg, MP Peppelenbosch, AC Spek
Thrombosis and haemostasis 86 (12), 1353-1359, 2001
1292001
Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathways
HH Versteeg, CA Spek, MP Peppelenbosch, DJ Richel
Molecular medicine 10 (1-6), 6-11, 2004
1262004
Hedgehog: an unusual signal transducer
MF Bijlsma, CA Spek, MP Peppelenbosch
Bioessays 26 (4), 387-394, 2004
1172004
Coagulation factors VIIa and Xa inhibit apoptosis and anoikis
HH Versteeg, CA Spek, DJ Richel, MP Peppelenbosch
Oncogene 23 (2), 410, 2004
1162004
Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation
K Borensztajn, J Stiekema, S Nijmeijer, PH Reitsma, MP Peppelenbosch, ...
The American journal of pathology 172 (2), 309-320, 2008
1122008
Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites
MF Bijlsma, KS Borensztajn, H Roelink, MP Peppelenbosch, CA Spek
Cellular signalling 19 (12), 2596-2604, 2007
1032007
Hedgehog signaling maintains chemoresistance in myeloid leukemic cells
KCS Queiroz, RR Ruela-de-Sousa, GM Fuhler, HL Aberson, CV Ferreira, ...
Oncogene 29 (48), 6314, 2010
982010
Tissue factor signal transduction in angiogenesis
HH Versteeg, MP Peppelenbosch, CA Spek
Carcinogenesis 24 (6), 1009-1013, 2003
892003
Disseminated intravascular coagulation
SH Slofstra, CA Spek, H Cate
The Hematology Journal 4 (5), 295-302, 2003
852003
Microvascular coagulopathy and disseminated intravascular coagulation
H ten Cate, SHHF Schoenmakers, R Franco, JJ Timmerman, AP Groot, ...
Critical care medicine 29 (7), S95-S97, 2001
842001
Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1–mediated vascular endothelial barrier enhancement
GL Van Sluis, TMH Niers, CT Esmon, W Tigchelaar, DJ Richel, HR Buller, ...
Blood 114 (9), 1968-1973, 2009
822009
mTOR inhibitor treatment of pancreatic cancer in a patient with Peutz-Jeghers syndrome
HJ Klümpen, KCS Queiroz, CA Spek, CJM Van Noesel, HC Brink, ...
Journal of clinical oncology: official journal of the American Society of …, 2011
802011
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Articles 1–20