C. Arnold Spek
C. Arnold Spek
Associate Professor
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Cited by
Repression of smoothened by patched-dependent (pro-) vitamin D3 secretion
MF Bijlsma, CA Spek, D Zivkovic, S van de Water, F Rezaee, ...
PLoS biology 4 (8), e232, 2006
Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses
PI Bonta, CM Van Tiel, M Vos, TWH Pols, JV Van Thienen, V Ferreira, ...
Arteriosclerosis, thrombosis, and vascular biology 26 (10), 2288-2288, 2006
The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation
RF Franco, E de Jonge, PEP Dekkers, JJ Timmerman, CA Spek, ...
Blood, The Journal of the American Society of Hematology 96 (2), 554-559, 2000
Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways
E Eldering, CA Spek, HL Aberson, A Grummels, IA Derks, AF de Vos, ...
Nucleic acids research 31 (23), e153-e153, 2003
Factor Xa: at the crossroads between coagulation and signaling in physiology and disease
K Borensztajn, MP Peppelenbosch, CA Spek
Trends in molecular medicine 14 (10), 429-440, 2008
Alternatively spliced tissue factor induces angiogenesis through integrin ligation
YW van den Berg, LG van den Hengel, HR Myers, O Ayachi, E Jordanova, ...
Proceedings of the National Academy of Sciences 106 (46), 19497-19502, 2009
Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers
NA Maris, AF de Vos, MC Dessing, CA Spek, R Lutter, HM Jansen, ...
American journal of respiratory and critical care medicine 172 (7), 878-884, 2005
Hedgehog signaling maintains chemoresistance in myeloid leukemic cells
KCS Queiroz, RR Ruela-de-Sousa, GM Fuhler, HL Aberson, CV Ferreira, ...
Oncogene 29 (48), 6314-6322, 2010
Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathways
HH Versteeg, CA Spek, MP Peppelenbosch, DJ Richel
Molecular medicine 10, 6-11, 2004
Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation
K Borensztajn, J Stiekema, S Nijmeijer, PH Reitsma, MP Peppelenbosch, ...
The American journal of pathology 172 (2), 309-320, 2008
The pleiotropic effects of tissue factor: a possible role for factor VIIa-induced intracellular signalling?
HH Versteeg, MP Peppelenbosch, AC Spek
Thrombosis and haemostasis 86 (12), 1353-1359, 2001
Coagulation factors VIIa and Xa inhibit apoptosis and anoikis
HH Versteeg, C Arnold Spek, DJ Richel, MP Peppelenbosch
Oncogene 23 (2), 410-417, 2004
Genotypic variation in the promoter region of the protein C gene is associated with plasma protein C levels and thrombotic risk
CA Spek, T Koster, FR Rosendaal, RM Bertina, PH Reitsma
Arteriosclerosis, thrombosis, and vascular biology 15 (2), 214-218, 1995
Hedgehog: an unusual signal transducer
MF Bijlsma, CA Spek, MP Peppelenbosch
Bioessays 26 (4), 387-394, 2004
Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites
MF Bijlsma, KS Borensztajn, H Roelink, MP Peppelenbosch, CA Spek
Cellular signalling 19 (12), 2596-2604, 2007
Hypoxia induces a hedgehog response mediated by HIF‐1α
MF Bijlsma, AP Groot, JP Oduro, RJ Franken, SHHF Schoenmakers, ...
Journal of cellular and molecular medicine 13 (8b), 2053-2060, 2009
Activated protein C protects against myocardial ischemia/reperfusion injury via inhibition of apoptosis and inflammation
STBG Loubele, CA Spek, P Leenders, R van Oerle, HL Aberson, ...
Arteriosclerosis, thrombosis, and vascular biology 29 (7), 1087-1092, 2009
Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency department
MD de Kruif, M Limper, H Gerritsen, CA Spek, DPM Brandjes, H ten Cate, ...
Critical care medicine 38 (2), 457-463, 2010
mTOR inhibitor treatment of pancreatic cancer in a patient with Peutz-Jeghers syndrome
HJ Klümpen, KCS Queiroz, CA Spek, CJM Van Noesel, HC Brink, ...
Journal of clinical oncology: official journal of the American Society of …, 2011
Microvascular coagulopathy and disseminated intravascular coagulation
H ten Cate, SHHF Schoenmakers, R Franco, JJ Timmerman, AP Groot, ...
Critical care medicine 29 (7), S95-S97, 2001
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