Johannes Huppa
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T-cell-antigen recognition and the immunological synapse
JB Huppa, MM Davis
Nature Reviews Immunology 3 (12), 973-983, 2003
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation
BF Lillemeier, MA Mörtelmaier, MB Forstner, JB Huppa, JT Groves, ...
Nature immunology 11 (1), 90-96, 2010
T cell killing does not require the formation of a stable mature immunological synapse
MA Purbhoo, DJ Irvine, JB Huppa, MM Davis
Nature immunology 5 (5), 524-530, 2004
TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity
JB Huppa, M Axmann, MA Mörtelmaier, BF Lillemeier, EW Newell, ...
Nature 463 (7283), 963-967, 2010
Continuous T cell receptor signaling required for synapse maintenance and full effector potential
JB Huppa, M Gleimer, C Sumen, MM Davis
Nature immunology 4 (8), 749-755, 2003
Agonist/endogenous peptide–MHC heterodimers drive T cell activation and sensitivity
M Krogsgaard, Q Li, C Sumen, JB Huppa, M Huse, MM Davis
Nature 434 (7030), 238-243, 2005
CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse
QJ Li, AR Dinner, S Qi, DJ Irvine, JB Huppa, MM Davis, AK Chakraborty
Nature immunology 5 (8), 791-799, 2004
Distinct TCR signaling pathways drive proliferation and cytokine production in T cells
CS Guy, KM Vignali, J Temirov, ML Bettini, AE Overacre, M Smeltzer, ...
Nature immunology 14 (3), 262-270, 2013
A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface
MF Kleijnen, JB Huppa, P Lucin, S Mukherjee, H Farrell, AE Campbell, ...
The EMBO journal, 1997
The α chain of the T cell antigen receptor is degraded in the cytosol
JB Huppa, HL Ploegh
Immunity 7 (1), 113-122, 1997
T cells as a self-referential, sensory organ
MM Davis, M Krogsgaard, M Huse, J Huppa, BF Lillemeier, Q Li
Annu. Rev. Immunol. 25, 681-695, 2007
Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1
S Jutz, J Leitner, K Schmetterer, I Doel-Perez, O Majdic, ...
Journal of immunological methods 430, 10-20, 2016
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses
B Agerer, M Koblischke, V Gudipati, LF Montaño-Gutierrez, M Smyth, ...
Science immunology 6 (57), eabg6461, 2021
Dynamics of cell surface molecules during T cell recognition
MM Davis, M Krogsgaard, JB Huppa, C Sumen, MA Purbhoo, DJ Irvine, ...
Annual review of biochemistry 72 (1), 717-742, 2003
Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential
D Tortorella, CM Story, JB Huppa, EJHJ Wiertz, TR Jones, HL Ploegh
The Journal of cell biology 142 (2), 365-376, 1998
Monomeric TCRs drive T cell antigen recognition
M Brameshuber, F Kellner, BK Rossboth, H Ta, K Alge, E Sevcsik, ...
Nature immunology 19 (5), 487-496, 2018
Linker for activation of T cells, ζ-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center …
MR Kuhné, J Lin, D Yablonski, MN Mollenauer, LIR Ehrlich, J Huppa, ...
The Journal of Immunology 171 (2), 860-866, 2003
RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics
E Salzer, D Cagdas, M Hons, EM Mace, W Garncarz, ÖY Petronczki, ...
Nature immunology 17 (12), 1352-1360, 2016
In vitro translation and assembly of a complete T cell receptor–CD3 complex
JB Huppa, HL Ploegh
The Journal of experimental medicine 186 (3), 393-403, 1997
TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells
B Rossboth, AM Arnold, H Ta, R Platzer, F Kellner, JB Huppa, ...
Nature immunology 19 (8), 821-827, 2018
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Artikelen 1–20