| Quantitative analysis of the microbial metabolome by isotope dilution mass spectrometry using uniformly 13C-labeled cell extracts as internal standards L Wu, MR Mashego, JC van Dam, AM Proell, JL Vinke, C Ras, ... Analytical biochemistry 336 (2), 164-171, 2005 | 466 | 2005 |
| MIRACLE: mass isotopomer ratio analysis of U‐13C‐labeled extracts. A new method for accurate quantification of changes in concentrations of intracellular metabolites MR Mashego, L Wu, JC Van Dam, C Ras, JL Vinke, WA Van Winden, ... Biotechnology and bioengineering 85 (6), 620-628, 2004 | 314 | 2004 |
| The sequence of a 1.8-Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways MH Medema, A Trefzer, A Kovalchuk, M Van Den Berg, U Müller, ... Genome Biology and Evolution 2, 212-224, 2010 | 238 | 2010 |
| Replacement of the Saccharomyces cerevisiae acetyl-CoA synthetases by alternative pathways for cytosolic acetyl-CoA synthesis BU Kozak, HM van Rossum, KR Benjamin, L Wu, JMG Daran, JT Pronk, ... Metabolic engineering 21, 46-59, 2014 | 118 | 2014 |
| Analysis of in vivo kinetics of glycolysis in aerobic Saccharomyces cerevisiae by application of glucose and ethanol pulses D Visser, GA van Zuylen, JC van Dam, MR Eman, A Pröll, C Ras, L Wu, ... Biotechnology and Bioengineering 88 (2), 157-167, 2004 | 112 | 2004 |
| Engineering acetyl coenzyme A supply: functional expression of a bacterial pyruvate dehydrogenase complex in the cytosol of Saccharomyces cerevisiae BU Kozak, HM van Rossum, MAH Luttik, M Akeroyd, KR Benjamin, L Wu, ... MBio 5 (5), e01696-14, 2014 | 105 | 2014 |
| Metabolic engineering toward sustainable production of nylon-6 SCHJ Turk, WP Kloosterman, DK Ninaber, KPAM Kolen, J Knutova, E Suir, ... ACS synthetic biology 5 (1), 65-73, 2016 | 97 | 2016 |
| A new framework for the estimation of control parameters in metabolic pathways using lin‐log kinetics L Wu, W Wang, WA van Winden, WM van Gulik, JJ Heijnen European Journal of Biochemistry 271 (16), 3348-3359, 2004 | 93 | 2004 |
| Short-Term Metabolome Dynamics and Carbon, Electron, and ATP Balances in Chemostat-Grown Saccharomyces cerevisiae CEN.PK 113-7D following a Glucose … L Wu, J van Dam, D Schipper, MTAP Kresnowati, AM Proell, C Ras, ... Applied and environmental microbiology 72 (5), 3566-3577, 2006 | 71 | 2006 |
| Iterative algorithm-guided design of massive strain libraries, applied to itaconic acid production in yeast EM Young, Z Zhao, BEM Gielesen, L Wu, DB Gordon, JA Roubos, ... Metabolic engineering 48, 33-43, 2018 | 47 | 2018 |
| In vivo kinetics of primary metabolism in Saccharomyces cerevisiae studied through prolonged chemostat cultivation L Wu, MR Mashego, AM Proell, JL Vinke, C Ras, J Van Dam, ... Metabolic Engineering 8 (2), 160-171, 2006 | 47 | 2006 |
| Determination of in vivo oxygen uptake and carbon dioxide evolution rates from off‐gas measurements under highly dynamic conditions L Wu, HC Lange, WM Van Gulik, JJ Heijnen Biotechnology and bioengineering 81 (4), 448-458, 2003 | 43 | 2003 |
| Diterpene production M Lehmann, J Trueheart, PZ Jens, L Wu, VM Boer, CMJ Sagt, M Kumar, ... US Patent App. 14/373,571, 2015 | 37 | 2015 |
| Application of metabolome data in functional genomics: a conceptual strategy L Wu, WA van Winden, WM van Gulik, JJ Heijnen Metabolic Engineering 7 (4), 302-310, 2005 | 28 | 2005 |
| Reconstruction of the O2 uptake rate and CO2 evolution rate on a time scale of seconds HHJ Bloemen, L Wu, WM Van Gulik, JJ Heijnen, MHG Verhaegen AIChE journal 49 (7), 1895-1908, 2003 | 28 | 2003 |
| Thermodynamics and economic feasibility of acetone production from syngas using the thermophilic production host Moorella thermoacetica S Redl, S Sukumara, T Ploeger, L Wu, T Ølshøj Jensen, AT Nielsen, ... Biotechnology for biofuels 10, 1-17, 2017 | 25 | 2017 |
| Acetyl-coa producing enzymes in yeast UM Müller, L Wu, LM Raamsdonk, AA Winkler US Patent App. 12/670,050, 2010 | 24 | 2010 |
| Replacement of the initial steps of ethanol metabolism in Saccharomyces cerevisiae by ATP-independent acetylating acetaldehyde dehydrogenase BU Kozak, HM van Rossum, MS Niemeijer, M van Dijk, K Benjamin, L Wu, ... FEMS Yeast Research 16 (2), 2016 | 16 | 2016 |
| Exploring Sequence Characteristics Related to High-Level Production of Secreted Proteins in Aspergillus niger BA van den Berg, MJT Reinders, M Hulsman, L Wu, HJ Pel, JA Roubos, ... Public Library of Science 7 (10), e45869, 2012 | 16 | 2012 |
| Adipate (ester or thioester) synthesis L Wu, AC Trefzer, SMA De Wildeman, MA Van Den Berg US Patent 9,096,873, 2015 | 14 | 2015 |
