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Manuela Hospenthal
Manuela Hospenthal
Group Leader at the Institute of Molecular Biology and Biophysics (IMBB), ETH Zürich, Switzerland
Geverifieerd e-mailadres voor mol.biol.ethz.ch - Homepage
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OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis
TET Mevissen, MK Hospenthal, PP Geurink, PR Elliott, M Akutsu, ...
Cell 154 (1), 169-184, 2013
5802013
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin
K Keusekotten, PR Elliott, L Glockner, BK Fiil, RB Damgaard, Y Kulathu, ...
Cell 153 (6), 1312-1326, 2013
4732013
A comprehensive guide to pilus biogenesis in Gram-negative bacteria
MK Hospenthal, TRD Costa, G Waksman
Nature reviews microbiology 15 (6), 365-379, 2017
2502017
Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest)
MK Hospenthal, TET Mevissen, D Komander
Nature protocols 10 (2), 349-361, 2015
2032015
Ubiquitin linkage-specific affimers reveal insights into K6-linked ubiquitin signaling
MA Michel, KN Swatek, MK Hospenthal, D Komander
Molecular cell 68 (1), 233-246. e5, 2017
1882017
Assembly, analysis and architecture of atypical ubiquitin chains
MK Hospenthal, SMV Freund, D Komander
Nature structural & molecular biology 20 (5), 555-565, 2013
1672013
Non-hydrolyzable diubiquitin probes reveal linkage-specific reactivity of deubiquitylating enzymes mediated by S2 pockets
D Flierman, R Ekkebus, PP Geurink, TET Mevissen, MK Hospenthal, ...
Cell chemical biology 23 (4), 472-482, 2016
1082016
Structure of a chaperone-usher pilus reveals the molecular basis of rod uncoiling
MK Hospenthal, A Redzej, K Dodson, M Ukleja, B Frenz, C Rodrigues, ...
Cell 164 (1), 269-278, 2016
692016
The cryoelectron microscopy structure of the type 1 chaperone-usher pilus rod
MK Hospenthal, D Zyla, TRD Costa, A Redzej, C Giese, J Lillington, ...
Structure 25 (12), 1829-1838. e4, 2017
442017
Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila
A Meir, K Macé, N Lukoyanova, D Chetrit, MK Hospenthal, A Redzej, ...
Nature communications 11 (1), 2864, 2020
382020
Structural insights into the architecture and membrane interactions of the conserved COMMD proteins
MD Healy, MK Hospenthal, RJ Hall, M Chandra, M Chilton, V Tillu, ...
Elife 7, e35898, 2018
292018
The remarkable biomechanical properties of the type 1 chaperone-usher pilus: a structural and molecular perspective
MK Hospenthal, G Waksman
Microbiology Spectrum 7 (1), 10.1128/microbiolspec. psib-0010-2018, 2019
262019
Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation
R Schuster, V Anton, T Simões, S Altin, F den Brave, T Hermanns, ...
Life science alliance 3 (1), 2020
122020
The molecular basis of FimT-mediated DNA uptake during bacterial natural transformation
SAG Braus, FL Short, S Holz, MJM Stedman, AD Gossert, MK Hospenthal
Nature Communications 13 (1), 1065, 2022
102022
Proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila
K Macé, A Meir, N Lukoyanova, L Liu, D Chetrit, MK Hospenthal, CR Roy, ...
Molecular Microbiology 117 (2), 307-319, 2022
72022
Ubiquitin chain analysis
TET Mevissen, MK Hospenthal, D Komander
US Patent 9,587,265, 2017
22017
Ubiquitin chain analysis
TET MEVISSEN, MK HOSPENTHAL, D Komander
12013
The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili
DS Zyla, T Wiegand, P Bachmann, R Zdanowicz, C Giese, BH Meier, ...
Nature Communications 15 (1), 3032, 2024
2024
Ubiquitin chain assembly
MK Hospenthal, D Komander
US Patent App. 14/346,169, 2014
2014
Enzymatic assembly, structure and hydrolysis of Lys6-linked ubiquitin chains
MK Hospenthal
University of Cambridge, 2014
2014
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Artikelen 1–20