piter bosma
piter bosma
associate professor of Gene Therapy, Tytgat Institute, AMC,Amsterdam
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The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome
PJ Bosma, JR Chowdhury, C Bakker, S Gantla, A de Boer, BA Oostra, ...
New England Journal of Medicine 333 (18), 1171-1175, 1995
Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
CC Paulusma, PJ Bosma, GJR Zaman, CTM Bakker, M Otter, GL Scheffer, ...
Science 271 (5252), 1126-1128, 1996
Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis
JML De Vree, E Jacquemin, E Sturm, D Cresteil, PJ Bosma, J Aten, ...
Proceedings of the National Academy of Sciences 95 (1), 282-287, 1998
A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin‐Johnson syndrome
CC Paulusma, M Kool, PJ Bosma, GL Scheffer, F ter Borg, RJ Scheper, ...
Hepatology 25 (6), 1539-1542, 1997
The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood
E Jacquemin, O Bernard, M Hadchouel, D Cresteil, JML De Vree, M Paul, ...
Gastroenterology 120 (6), 1448-1458, 2001
Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.
PJ Bosma, J Seppen, B Goldhoorn, C Bakker, RPO Elferink, ...
Journal of Biological Chemistry 269 (27), 17960-17964, 1994
Inherited disorders of bilirubin metabolism
PJ Bosma
Journal of hepatology 38 (1), 107-117, 2003
Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus
CJ Buskens, BP Van Rees, A Sivula, JB Reitsma, C Haglund, PJ Bosma, ...
Gastroenterology 122 (7), 1800-1807, 2002
Plasminogen activator inhibitor 1: biosynthesis and mRNA level are increased by insulin in cultured human hepatocytes
T Kooistra, PJ Bosma, HAM Töns, AP Van Den Berg, P Meyer, ...
Thrombosis and haemostasis 62 (06), 723-728, 1989
Human plasminogen activator inhibitor-1 gene. Promoter and structural gene nucleotide sequences.
PJ Bosma, EA van den Berg, T Kooistra, DR Siemieniak, JL Slightom
Journal of Biological Chemistry 263 (19), 9129-9141, 1988
Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis
JML De Vree, R Ottenhoff, PJ Bosma, AJ Smith, J Aten, RPJO Elferink
Gastroenterology 119 (6), 1720-1730, 2000
Sequence of exons and the flanking regions of human bilirubin‐UDP‐glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler‐Najjar …
PJ Bosma, NR Chowdhury, BG Goldhoorn, MH Hofker, RPJO Elferink, ...
Hepatology 15 (5), 941-947, 1992
Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase.
J Seppen, PJ Bosma, BG Goldhoorn, CT Bakker, JR Chowdhury, ...
The Journal of clinical investigation 94 (6), 2385-2391, 1994
Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteins
W Boers, S Aarrass, C Linthorst, M Pinzani, RO Elferink, P Bosma
Journal of Biological Chemistry 281 (24), 16289-16295, 2006
Zonal down‐regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver
CC Paulusma, MJ Kothe, CT Bakker, PJ Bosma, I van Bokhoven, ...
Hepatology 31 (3), 684-693, 2000
Improved gene transfer efficiency to primary and established human pancreatic carcinoma target cells via epidermal growth factor receptor and integrin-targeted adenoviral vectors
JG Wesseling, PJ Bosma, V Krasnykh, EA Kashentseva, JL Blackwell, ...
Gene Therapy 8 (13), 969-976, 2001
Mechanisms of inherited deficiencies of multiple UDP‐glucuronosyltransferase isoforms in two patients with Crigler‐Najjar syndrome, type I
PJ Bosma, JR Chowdhury, TJ Huang, P Lahiri, RPJO Elferink, ...
The FASEB Journal 6 (10), 2859-2863, 1992
A mutation in bilirubin uridine 5′-diphosphate-glucuronosyltransferase isoform 1 causing Crigler-Najjar syndrome type II
PJ Bosma, B Goldhoorn, RPJO Elferink, M Sinaasappel, BA Oostra, ...
Gastroenterology 105 (1), 216-220, 1993
Towards liver-directed gene therapy for Crigler-Najjar syndrome
PS Montenegro Miranda, PJ Bosma
Current Gene Therapy 9 (2), 72-82, 2009
Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats
J Seppen, C Bakker, B De Jong, C Kunne, K Van Den Oever, ...
Molecular Therapy 13 (6), 1085-1092, 2006
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