Walker-A motif acts to coordinate ATP hydrolysis with motor output in viral DNA packaging D Ortiz, M Ordyan, J Sippy, CS Oh, N Keller, M Feiss, CE Catalano, ... Journal of molecular biology 428 (13), 2709-2729, 2016 | 45 | 2016 |
Reinterpreting the action of ATP analogs on KATP channels D Ortiz, L Gossack, U Quast, J Bryan Journal of Biological Chemistry 288 (26), 18894-18902, 2013 | 38 | 2013 |
CYP26C1 is a hydroxylase of multiple active retinoids and interacts with cellular retinoic acid binding proteins G Zhong, D Ortiz, A Zelter, A Nath, N Isoherranen Molecular pharmacology 93 (5), 489-503, 2018 | 34 | 2018 |
Importance of the Kir6.2 N-terminus for the interaction of glibenclamide and repaglinide with the pancreatic KATP channel P Kühner, R Prager, D Stephan, U Russ, M Winkler, D Ortiz, J Bryan, ... Naunyn-Schmiedeberg's archives of pharmacology 385, 299-311, 2012 | 27 | 2012 |
Two neonatal diabetes mutations on transmembrane helix 15 of SUR1 increase affinity for ATP and ADP at nucleotide binding domain 2 D Ortiz, P Voyvodic, L Gossack, U Quast, J Bryan Journal of Biological Chemistry 287 (22), 17985-17995, 2012 | 24 | 2012 |
Thermodynamic Interrogation of the Assembly of a Viral Genome Packaging Motor Complex CCE Yang TC, Ortiz D, Nosaka L, Lander GC Biophys J., 2015 | 19 | 2015 |
Functional dissection of a viral DNA packaging Machine's Walker B Motif D Ortiz, M Ordyan, J Pajak, J Sippy, A Catala, CS Oh, A Vu, G Arya, ... Journal of molecular biology 431 (22), 4455-4474, 2019 | 16 | 2019 |
Evidence that a catalytic glutamate and an ‘Arginine Toggle’act in concert to mediate ATP hydrolysis and mechanochemical coupling in a viral DNA packaging motor D Ortiz, D delToro, M Ordyan, J Pajak, J Sippy, A Catala, CS Oh, A Vu, ... Nucleic acids research 47 (3), 1404-1415, 2019 | 15 | 2019 |
Neonatal diabetes and congenital hyperinsulinism caused by mutations in ABCC8/SUR1 are associated with altered and opposite affinities for ATP and ADP D Ortiz, J Bryan Frontiers in endocrinology 6, 124161, 2015 | 13 | 2015 |
Physical and functional characterization of a viral genome maturation complex TC Yang, D Ortiz, Q Yang, RW De Angelis, SJ Sanyal, CE Catalano Biophysical Journal 112 (8), 1551-1560, 2017 | 11 | 2017 |
Development of novel antibody–camptothecin conjugates RD Lyski, LB Bou, UY Lau, DW Meyer, JH Cochran, NM Okeley, ... Molecular Cancer Therapeutics 20 (2), 329-339, 2021 | 10 | 2021 |
Some remarks on Fitzpatrick and Flynn’s Gröbner basis technique for Padé approximation JB Little, D Ortiz, R Ortiz-Rosado, R Pablo, K Rıos-Soto Journal of Symbolic Computation 35 (4), 451-461, 2003 | 9 | 2003 |
Role of the amino-terminal transmembrane domain of sulfonylurea receptor SUR2B for coupling to KIR6.2, ligand binding, and oligomerization M Winkler, P Kühner, U Russ, D Ortiz, J Bryan, U Quast Naunyn-Schmiedeberg's archives of pharmacology 385, 287-298, 2012 | 7 | 2012 |
Physical and functional characterization of nucleoprotein complexes along a viral assembly pathway TC Yang, D Ortiz, Q Yang, RD Angelis, SJ Sanyal, CE Catalano Biophys. J 112, 1551-1560, 2017 | 6 | 2017 |
Discovery of a tripeptide-based camptothecin drug-linker for antibody-drug conjugates with potent antitumor activity and a broad therapeutic window R Lyski, L Bou, M Zaval, K Emmerton, N Okeley, J Simmons, F Zapata, ... Cancer Research 80 (16_Supplement), 2885-2885, 2020 | 4 | 2020 |
SGN-ALPV a novel, investigational vedotin ADC demonstrates highly effective targeting of oncofetal phosphatases ALPP and ALPPL2 in preclinical models S Anderson, N Hansen, R Lawrence, AT Chande, D Ortiz, C Carosino, ... Cancer Research 82 (12_Supplement), 1766-1766, 2022 | 1 | 2022 |
Bronchioalveolar organoids: A preclinical tool to screen toxicity associated with antibody-drug conjugates TN McCray, V Nguyen, JS Heins, E Nguyen, K Stewart, CT Ford, C Neace, ... Toxicology and Applied Pharmacology 485, 116886, 2024 | | 2024 |
Development of a topoisomerase 1 inhibitor platform technology for efficacious and well tolerated ADCs R Lyski, L Bou, J Sigurjonsson, D Meyer, C Neace, D Ortiz, K Snead, ... Cancer Research 84 (6_Supplement), 5733-5733, 2024 | | 2024 |
Abstract C113: Discovery of a novel auristatin antibody drug conjugate drug linker with equal efficacy and reduced bone marrow toxicity compared to vedotin NA Bindman, R Yumul, EE McKinney, S Blackburn, N Blesie, X Zhang, ... Molecular Cancer Therapeutics 22 (12_Supplement), C113-C113, 2023 | | 2023 |
Utilizing PDX models to better understand factors that predict response to SGN-CD228A, an antibody drug-conjugate (ADC) for solid tumors S Sandall, R Mazahreh, M Mason, J Gosink, C Hale, S Allred, R Hu, ... Cancer Research 80 (16_Supplement), 2888-2888, 2020 | | 2020 |