| Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21) DL Mallery, WA McEwan, SR Bidgood, GJ Towers, CM Johnson, ... Proceedings of the National Academy of Sciences 107 (46), 19985-19990, 2010 | 529 | 2010 |
| A method for the acute and rapid degradation of endogenous proteins D Clift, WA McEwan, LI Labzin, V Konieczny, B Mogessie, LC James, ... Cell 171 (7), 1692-1706. e18, 2017 | 409 | 2017 |
| Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21 WA McEwan, JCH Tam, RE Watkinson, SR Bidgood, DL Mallery, ... Nature immunology 14 (4), 327-336, 2013 | 380 | 2013 |
| Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly AJ Price, DA Jacques, WA McEwan, AJ Fletcher, S Essig, JW Chin, ... PLoS pathogens 10 (10), e1004459, 2014 | 278 | 2014 |
| HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis DA Jacques, WA McEwan, L Hilditch, AJ Price, GJ Towers, LC James Nature 536 (7616), 349-353, 2016 | 234 | 2016 |
| Intracellular sensing of complement C3 activates cell autonomous immunity JCH Tam, SR Bidgood, WA McEwan, LC James Science 345 (6201), 1256070, 2014 | 178 | 2014 |
| IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis DL Mallery, CL Marquez, WA McEwan, CF Dickson, DA Jacques, ... Elife 7, e35335, 2018 | 157 | 2018 |
| Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation WA McEwan, B Falcon, M Vaysburd, D Clift, AL Oblak, B Ghetti, ... Proceedings of the National Academy of Sciences 114 (3), 574-579, 2017 | 152 | 2017 |
| Acute and rapid degradation of endogenous proteins by Trim-Away D Clift, C So, WA McEwan, LC James, M Schuh Nature Protocols 13 (10), 2149-2175, 2018 | 127 | 2018 |
| Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species E Nachman, AS Wentink, K Madiona, L Bousset, T Katsinelos, K Allinson, ... Journal of Biological Chemistry 295 (28), 9676-9690, 2020 | 110 | 2020 |
| AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization F Hauler, DL Mallery, WA McEwan, SR Bidgood, LC James Proceedings of the National Academy of Sciences 109 (48), 19733-19738, 2012 | 101 | 2012 |
| TRIM21 promotes cGAS and RIG-I sensing of viral genomes during infection by antibody-opsonized virus RE Watkinson, WA McEwan, JCH Tam, M Vaysburd, LC James PLoS pathogens 11 (10), e1005253, 2015 | 96 | 2015 |
| Regulation of virus neutralization and the persistent fraction by TRIM21 WA McEwan, F Hauler, CR Williams, SR Bidgood, DL Mallery, ... Journal of virology 86 (16), 8482-8491, 2012 | 90 | 2012 |
| Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells SR Bidgood, JCH Tam, WA McEwan, DL Mallery, LC James Proceedings of the National Academy of Sciences 111 (37), 13463-13468, 2014 | 89 | 2014 |
| Measurement of tau filament fragmentation provides insights into prion-like spreading F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, ... ACS chemical neuroscience 9 (6), 1276-1282, 2018 | 79 | 2018 |
| Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates JH Brelstaff, M Mason, T Katsinelos, WA McEwan, B Ghetti, AM Tolkovsky, ... Science advances 7 (43), eabg4980, 2021 | 72 | 2021 |
| Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat WA McEwan, T Schaller, LM Ylinen, MJ Hosie, GJ Towers, BJ Willett Journal of virology 83 (16), 8270-8275, 2009 | 72 | 2009 |
| Intracellular antibody‐mediated immunity and the role of TRIM21 WA McEwan, DL Mallery, DA Rhodes, J Trowsdale, LC James BioEssays, 2011 | 66 | 2011 |
| Target-induced clustering activates Trim-Away of pathogens and proteins J Zeng, AF Santos, AS Mukadam, M Osswald, DA Jacques, CF Dickson, ... Nature structural & molecular biology 28 (3), 278-289, 2021 | 49 | 2021 |
| The role of antibodies and their receptors in protection against ordered protein assembly in neurodegeneration T Katsinelos, BJ Tuck, AS Mukadam, WA McEwan Frontiers in Immunology 10, 445574, 2019 | 43 | 2019 |
Leo JamesMRC Laboratory of Molecular BiologyVerified email at mrc-lmb.cam.ac.uk
