William A McEwan
William A McEwan
UK Dementia Research Institute, University of Cambridge
Geverifieerd e-mailadres voor cam.ac.uk - Homepage
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Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
DL Mallery, WA McEwan, SR Bidgood, GJ Towers, CM Johnson, ...
Proceedings of the National Academy of Sciences 107 (46), 19985-19990, 2010
A method for the acute and rapid degradation of endogenous proteins
D Clift, WA McEwan, LI Labzin, V Konieczny, B Mogessie, LC James, ...
Cell 171 (7), 1692-1706. e18, 2017
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21
WA McEwan, JCH Tam, RE Watkinson, SR Bidgood, DL Mallery, ...
Nature immunology 14 (4), 327-336, 2013
Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly
AJ Price, DA Jacques, WA McEwan, AJ Fletcher, S Essig, JW Chin, ...
PLoS pathogens 10 (10), e1004459, 2014
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
DA Jacques, WA McEwan, L Hilditch, AJ Price, GJ Towers, LC James
Nature 536 (7616), 349-353, 2016
Intracellular sensing of complement C3 activates cell autonomous immunity
JCH Tam, SR Bidgood, WA McEwan, LC James
Science 345 (6201), 1256070, 2014
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
DL Mallery, CL Marquez, WA McEwan, CF Dickson, DA Jacques, ...
Elife 7, e35335, 2018
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation
WA McEwan, B Falcon, M Vaysburd, D Clift, AL Oblak, B Ghetti, ...
Proceedings of the National Academy of Sciences 114 (3), 574-579, 2017
Acute and rapid degradation of endogenous proteins by Trim-Away
D Clift, C So, WA McEwan, LC James, M Schuh
Nature Protocols 13 (10), 2149-2175, 2018
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species
E Nachman, AS Wentink, K Madiona, L Bousset, T Katsinelos, K Allinson, ...
Journal of Biological Chemistry 295 (28), 9676-9690, 2020
AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization
F Hauler, DL Mallery, WA McEwan, SR Bidgood, LC James
Proceedings of the National Academy of Sciences 109 (48), 19733-19738, 2012
TRIM21 promotes cGAS and RIG-I sensing of viral genomes during infection by antibody-opsonized virus
RE Watkinson, WA McEwan, JCH Tam, M Vaysburd, LC James
PLoS pathogens 11 (10), e1005253, 2015
Regulation of virus neutralization and the persistent fraction by TRIM21
WA McEwan, F Hauler, CR Williams, SR Bidgood, DL Mallery, ...
Journal of virology 86 (16), 8482-8491, 2012
Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells
SR Bidgood, JCH Tam, WA McEwan, DL Mallery, LC James
Proceedings of the National Academy of Sciences 111 (37), 13463-13468, 2014
Measurement of tau filament fragmentation provides insights into prion-like spreading
F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, ...
ACS chemical neuroscience 9 (6), 1276-1282, 2018
Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates
JH Brelstaff, M Mason, T Katsinelos, WA McEwan, B Ghetti, AM Tolkovsky, ...
Science advances 7 (43), eabg4980, 2021
Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat
WA McEwan, T Schaller, LM Ylinen, MJ Hosie, GJ Towers, BJ Willett
Journal of virology 83 (16), 8270-8275, 2009
Intracellular antibody‐mediated immunity and the role of TRIM21
WA McEwan, DL Mallery, DA Rhodes, J Trowsdale, LC James
BioEssays, 2011
Target-induced clustering activates Trim-Away of pathogens and proteins
J Zeng, AF Santos, AS Mukadam, M Osswald, DA Jacques, CF Dickson, ...
Nature structural & molecular biology 28 (3), 278-289, 2021
The role of antibodies and their receptors in protection against ordered protein assembly in neurodegeneration
T Katsinelos, BJ Tuck, AS Mukadam, WA McEwan
Frontiers in Immunology 10, 1139, 2019
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Artikelen 1–20