Olaf van Tellingen
Olaf van Tellingen
Verified email at nki.nl
Cited by
Cited by
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
AH Schinkel, JJM Smit, O van Tellingen, JH Beijnen, E Wagenaar, ...
Cell 77 (4), 491-502, 1994
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
AH Schinkel, U Mayer, E Wagenaar, CAAM Mol, L Van Deemter, JJM Smit, ...
Proceedings of the National Academy of Sciences 94 (8), 4028-4033, 1997
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
A Sparreboom, J Van Asperen, U Mayer, AH Schinkel, JW Smit, ...
Proceedings of the National Academy of Sciences 94 (5), 2031-2035, 1997
Potent and Specific Inhibition of the Breast Cancer Resistance Protein Multidrug Transporter in Vitro and in Mouse Intestine by a Novel Analogue of Fumitremorgin C 1 This work …
JD Allen, A Van Loevezijn, JM Lakhai, M Van Der Valk, O Van Tellingen, ...
Molecular cancer therapeutics 1 (6), 417-425, 2002
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein
GJ Zaman, J Lankelma, O vAN Tellingen, J Beijnen, H Dekker, ...
Proceedings of the National Academy of Sciences 92 (17), 7690-7694, 1995
Overcoming the blood–brain tumor barrier for effective glioblastoma treatment
O Van Tellingen, B Yetkin-Arik, MC De Gooijer, P Wesseling, T Wurdinger, ...
Drug Resistance Updates 19, 1-12, 2015
The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein …
P Breedveld, D Pluim, G Cipriani, P Wielinga, O van Tellingen, ...
Cancer research 65 (7), 2577-2582, 2005
Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure
JW Smit, MT Huisman, O van Tellingen, HR Wiltshire, AH Schinkel
The Journal of clinical investigation 104 (10), 1441-1447, 1999
Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL
A Sparreboom, O van Tellingen, WJ Nooijen, JH Beijnen
Cancer research 56 (9), 2112-2115, 1996
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer
S Rottenberg, AOH Nygren, M Pajic, FWB van Leeuwen, ...
Proceedings of the National Academy of Sciences 104 (29), 12117-12122, 2007
Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma
SWM Bruggeman, D Hulsman, E Tanger, T Buckle, M Blom, ...
Cancer cell 12 (4), 328-341, 2007
Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin
B Pang, X Qiao, L Janssen, A Velds, T Groothuis, R Kerkhoven, ...
Nature communications 4 (1), 1-13, 2013
P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan
NA de Vries, J Zhao, E Kroon, T Buckle, JH Beijnen, O van Tellingen
Clinical Cancer Research 13 (21), 6440-6449, 2007
Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein
EM Kemper, AE van Zandbergen, C Cleypool, HA Mos, W Boogerd, ...
Clinical Cancer Research 9 (7), 2849-2855, 2003
Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions
P Breedveld, N Zelcer, D Pluim, Ö Sönmezer, MM Tibben, JH Beijnen, ...
Cancer research 64 (16), 5804-5811, 2004
Coadministration of oral cyclosporin A enables oral therapy with paclitaxel
JMM Terwogt, MM Malingré, JH Beijnen, W Wim, H Rosing, FJ Koopman, ...
Clinical Cancer Research 5 (11), 3379-3384, 1999
Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833
J Van Asperen, O Van Tellingen, A Sparreboom, AH Schinkel, P Borst, ...
British journal of cancer 76 (9), 1181-1183, 1997
Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat
R Seigers, SB Schagen, W Beerling, W Boogerd, O Van Tellingen, ...
Behavioural brain research 186 (2), 168-175, 2008
Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: pharmacokinetics and cisplatin–DNA adduct formation in patients and ovarian cancer cell lines
PJM Van de Vaart, N Van der Vange, FAN Zoetmulder, AR Van Goethem, ...
European journal of cancer 34 (1), 148-154, 1998
MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid
MT Huisman, AA Chhatta, O van Tellingen, JH Beijnen, AH Schinkel
International journal of cancer 116 (5), 824-829, 2005
The system can't perform the operation now. Try again later.
Articles 1–20