Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia T Pemovska, M Kontro, B Yadav, H Edgren, S Eldfors, A Szwajda, ... Cancer discovery 3 (12), 1416-1429, 2013 | 450* | 2013 |
GDNF family receptor complexes are emerging drug targets MM Bespalov, M Saarma Trends in pharmacological sciences 28 (2), 68-74, 2007 | 252 | 2007 |
Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin MM Bespalov, YA Sidorova, S Tumova, A Ahonen-Bishopp, ... Journal of Cell Biology 192 (1), 153-169, 2011 | 246 | 2011 |
Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses FS Varghese, P Kaukinen, S Gläsker, M Bespalov, L Hanski, ... Antiviral research 126, 117-124, 2016 | 222 | 2016 |
Human pluripotent reprogramming with CRISPR activators J Weltner, D Balboa, S Katayama, M Bespalov, K Krjutškov, EM Jouhilahti, ... Nature communications 9 (1), 2643, 2018 | 167 | 2018 |
The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding V Parkash, VM Leppanen, H Virtanen, JM Jurvansuu, MM Bespalov, ... Journal of Biological Chemistry 283 (50), 35164-35172, 2008 | 106 | 2008 |
Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism S Kuivanen, MM Bespalov, J Nandania, A Ianevski, V Velagapudi, ... Antiviral research 139, 117-128, 2017 | 101 | 2017 |
The structure of GFRα1 domain 3 reveals new insights into GDNF binding and RET activation VM Leppänen, MM Bespalov, P Runeberg‐Roos, Ü Puurand, A Merits, ... The EMBO journal 23 (7), 1452-1462, 2004 | 90 | 2004 |
The structure of GFRα1 domain 3 reveals new insights into GDNF binding and RET activation VM Leppänen, MM Bespalov, P Runeberg‐Roos, Ü Puurand, A Merits, ... The EMBO journal 23 (7), 1452-1462, 2004 | 90 | 2004 |
Lack ofl-Iduronic Acid in Heparan Sulfate Affects Interaction with Growth Factors and Cell Signaling J Jia, M Maccarana, X Zhang, M Bespalov, U Lindahl, JP Li Journal of Biological Chemistry 284 (23), 15942-15950, 2009 | 81 | 2009 |
Persephin signaling through GFRα1: the potential for the treatment of Parkinson's disease YA Sidorova, K Mätlik, M Paveliev, M Lindahl, E Piranen, J Milbrandt, ... Molecular and Cellular Neuroscience 44 (3), 223-232, 2010 | 54 | 2010 |
A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in … YA Sidorova, MM Bespalov, AW Wong, O Kambur, V Jokinen, TO Lilius, ... Frontiers in pharmacology 8, 365, 2017 | 53 | 2017 |
Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons M Piltonen, MM Bespalov, D Ervasti, T Matilainen, YA Sidorova, ... Experimental neurology 219 (2), 499-506, 2009 | 52 | 2009 |
Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease P Runeberg-Roos, E Piccinini, AM Penttinen, K Mätlik, H Heikkinen, ... Neurobiology of disease 96, 335-345, 2016 | 51 | 2016 |
Bone Morphogenetic Protein–Inducer Tilorone Identified by High-Throughput Screening Is Antifibrotic In Vivo O Leppäranta, JM Tikkanen, MM Bespalov, K Koli, M Myllärniemi American journal of respiratory cell and molecular biology 48 (4), 448-455, 2013 | 46 | 2013 |
Glial cell line–derived neurotrophic factor receptor rearranged during transfection agonist supports dopamine neurons in vitro and enhances dopamine release in vivo AK Mahato, J Kopra, JM Renko, T Visnapuu, I Korhonen, N Pulkkinen, ... Movement Disorders 35 (2), 245-255, 2020 | 32 | 2020 |
Stabilization of enzymes by anabiosis autoinducers as a possible mechanism of resistance of resting microbial forms AI Kolpakov, ON Il'inskaia, MM Bespalov, FG Kupriianova-Ashina, ... Mikrobiologiia 69 (2), 224-230, 2000 | 32 | 2000 |
The first cysteine-rich domain of the receptor GFRα1 stabilizes the binding of GDNF H Virtanen, J Yang, MM Bespalov, JO Hiltunen, VM Leppänen, ... Biochemical Journal 387 (3), 817-824, 2005 | 31 | 2005 |
The role of microbial dormancy autoinducers in metabolism blockade MM Bespalov, AI Kolpakov, NG Loiko, EV Doroshenko, AL Mulyukin, ... Microbiology 69, 174-179, 2000 | 29 | 2000 |
Sensory neurons from N-syndecan-deficient mice are defective in survival M Paveliev, A Hienola, E Jokitalo, A Planken, MM Bespalov, H Rauvala, ... Neuroreport 19 (14), 1397-1400, 2008 | 16 | 2008 |