| Tailoring recombinant protein quality by rational media design D Brühlmann, M Jordan, J Hemberger, M Sauer, M Stettler, H Broly Biotechnology progress 31 (3), 615-629, 2015 | 85 | 2015 |
| Mechanistic reconstruction of glycoprotein secretion through monitoring of intracellular N-glycan processing I Arigoni-Affolter, E Scibona, CW Lin, D Brühlmann, J Souquet, H Broly, ... Science advances 5 (11), eaax8930, 2019 | 42 | 2019 |
| Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality D Brühlmann, M Sokolov, A Butté, M Sauer, J Hemberger, J Souquet, ... Biotechnology and bioengineering 114 (7), 1448-1458, 2017 | 41 | 2017 |
| Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures S Hutter, TK Villiger, D Brühlmann, M Stettler, H Broly, M Soos, ... Metabolic engineering 43, 9-20, 2017 | 40 | 2017 |
| Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody M Sokolov, J Ritscher, N MacKinnon, JM Bielser, D Brühlmann, ... Biotechnology progress 33 (1), 181-191, 2017 | 37 | 2017 |
| Screening and assessment of performance and molecule quality attributes of industrial cell lines across different fed‐batch systems Y Rouiller, JM Bielser, D Brühlmann, M Jordan, H Broly, M Stettler Biotechnology progress 32 (1), 160-170, 2016 | 35 | 2016 |
| Cell culture process metabolomics together with multivariate data analysis tools opens new routes for bioprocess development and glycosylation prediction P Zürcher, M Sokolov, D Brühlmann, R Ducommun, M Stettler, J Souquet, ... Biotechnology progress 36 (5), e3012, 2020 | 32 | 2020 |
| Cell culture media supplemented with raffinose reproducibly enhances high mannose glycan formation D Brühlmann, A Muhr, R Parker, T Vuillemin, B Bucsella, F Kalman, ... Journal of biotechnology 252, 32-42, 2017 | 22 | 2017 |
| Generation of site‐distinct N‐glycan variants for in vitro bioactivity testing D Brühlmann, T Vuillemin, A Satwekar, E Galano, A Palmese, A D'Angelo, ... Biotechnology and Bioengineering 116 (5), 1017-1028, 2019 | 7 | 2019 |
| The potential of small molecules to modulate glycosylation by media design D Brühlmann, A Muhr, J Hemberger, M Sauer, H Kornmann, M Jordan, ... BMC Proceedings 9, 1-3, 2015 | 1 | 2015 |
| Generating glycan variants for biological activity testing by means of parallel experimental design and multivariate analysis D Bruehlmann, M Jordan, M Sokolov, A Butté, A Satwekar, A D’Angelo, ... | | 2018 |
| ted D Brühlmann, M Sokolov, A Butté, M Sauer, J Hemberger, J Souquet, ... | | |
