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David Lomas
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Susceptibility to exacerbation in COPD
JR Hurst, A Anzueto, J Vestbo
The Lancet Respiratory Medicine 5 (9), e29, 2017
35302017
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins
GA Silverman, PI Bird, RW Carrell, FC Church, PB Coughlin, PGW Gettins, ...
Journal of Biological Chemistry 276 (36), 33293-33296, 2001
15692001
Characterisation of COPD heterogeneity in the ECLIPSE cohort
A Agusti, PMA Calverley, B Celli, HO Coxson, LD Edwards, DA Lomas, ...
Respiratory research 11, 1-14, 2010
15152010
The mechanism of Z α1-antitrypsin accumulation in the liver
DA Lomas, D Li-Evans, JT Finch, RW Carrell
Nature 357 (6379), 605-607, 1992
12411992
Conformational disease
RW Carrell, DA Lomas
The Lancet 350 (9071), 134-138, 1997
12181997
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers
M Bafadhel, S McKenna, S Terry, V Mistry, C Reid, P Haldar, ...
American journal of respiratory and critical care medicine 184 (6), 662-671, 2011
12082011
Changes in forced expiratory volume in 1 second over time in COPD
J Vestbo, LD Edwards, PD Scanlon, JC Yates, A Agusti, P Bakke, ...
New England Journal of Medicine 365 (13), 1184-1192, 2011
11252011
Once-daily single-inhaler triple versus dual therapy in patients with COPD
DA Lipson, F Barnhart, N Brealey, J Brooks, GJ Criner, NC Day, ...
New England Journal of Medicine 378 (18), 1671-1680, 2018
10902018
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype
A Agustí, LD Edwards, SI Rennard, W MacNee, R Tal-Singer, BE Miller, ...
PloS one 7 (5), e37483, 2012
9822012
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci
SG Pillai, D Ge, G Zhu, X Kong, KV Shianna, AC Need, S Feng, CP Hersh, ...
PLoS genetics 5 (3), e1000421, 2009
8432009
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells
K Yusa, ST Rashid, H Strick-Marchand, I Varela, PQ Liu, DE Paschon, ...
Nature 478 (7369), 391-394, 2011
8072011
Evaluation of COPD longitudinally to identify predictive surrogate end-points (ECLIPSE)
J Vestbo, W Anderson, HO Coxson, C Crim, F Dawber, L Edwards, ...
European Respiratory Journal 31 (4), 869-873, 2008
8042008
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells
ST Rashid, S Corbineau, N Hannan, SJ Marciniak, E Miranda, ...
The Journal of clinical investigation 120 (9), 3127-3136, 2010
7182010
Mapping the human genetic architecture of COVID-19
Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ...
Nature 600 (7889), 472-477, 2021
7002021
Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial
M Bafadhel, S McKenna, S Terry, V Mistry, M Pancholi, P Venge, ...
American journal of respiratory and critical care medicine 186 (1), 48-55, 2012
6562012
Alpha1-Antitrypsin Deficiency — A Model for Conformational Diseases
RW Carrell, DA Lomas
New England Journal of Medicine 346 (1), 45-53, 2002
5692002
Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort
J Miller, LD Edwards, A Agustí, P Bakke, PMA Calverley, B Celli, ...
Respiratory medicine 107 (9), 1376-1384, 2013
5292013
Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease
BR Celli, N Locantore, J Yates, R Tal-Singer, BE Miller, P Bakke, ...
American journal of respiratory and critical care medicine 185 (10), 1065-1072, 2012
5182012
Variants in FAM13A are associated with chronic obstructive pulmonary disease
MH Cho, N Boutaoui, BJ Klanderman, JS Sylvia, JP Ziniti, CP Hersh, ...
Nature genetics 42 (3), 200-202, 2010
4692010
Endoplasmic reticulum dysfunction in neurological disease
BD Roussel, AJ Kruppa, E Miranda, DC Crowther, DA Lomas, ...
The Lancet Neurology 12 (1), 105-118, 2013
4652013
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