John F. Engelhardt, Ph.D.
John F. Engelhardt, Ph.D.
Professor and Chair, Department of Anatomy and Cell Biology
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A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
DT Montoro, AL Haber, M Biton, V Vinarsky, B Lin, SE Birket, F Yuan, ...
Nature 560 (7718), 319-324, 2018
Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.
JF Engelhardt, X Ye, B Doranz, JM Wilson
Proceedings of the National Academy of Sciences 91 (13), 6196-6200, 1994
Submucosal glands are the predominant site of CFTR expression in the human bronchus
JF Engelhardt, JR Yankaskas, SA Ernst, Y Yang, CR Marino, RC Boucher, ...
Nature genetics 2 (3), 240-248, 1992
Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia
M Grossman, SE Raper, K Kozarsky, EA Stein, JF Engelhardt, D Muller, ...
Nature genetics 6 (4), 335-341, 1994
A controlled study of adenoviral-vector–mediated gene transfer in the nasal epithelium of patients with cystic fibrosis
MR Knowles, KW Hohneker, Z Zhou, JC Olsen, TL Noah, PC Hu, ...
New England Journal of Medicine 333 (13), 823-831, 1995
Modular flexibility of dystrophin: implications for gene therapy of Duchenne muscular dystrophy
SQ Harper, MA Hauser, C DelloRusso, D Duan, RW Crawford, SF Phelps, ...
Nature medicine 8 (3), 253-261, 2002
Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue
D Duan, P Sharma, J Yang, Y Yue, L Dudus, Y Zhang, KJ Fisher, ...
Journal of virology 72 (11), 8568-8577, 1998
Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis
Y Yang, FA Nunes, K Berencsi, E Gönczöl, JF Engelhardt, JM Wilson
Nature genetics 7 (3), 362-369, 1994
Production of CFTR-null and CFTR-ΔF508 heterozygous pigs by adeno-associated virus–mediated gene targeting and somatic cell nuclear transfer
CS Rogers, Y Hao, T Rokhlina, M Samuel, DA Stoltz, Y Li, E Petroff, ...
The Journal of clinical investigation 118 (4), 1571-1577, 2008
Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-α secretion through IKK regulation of NF-κB
S Sanlioglu, CM Williams, L Samavati, NS Butler, G Wang, PB McCray, ...
Journal of Biological Chemistry 276 (32), 30188-30198, 2001
Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis
TH Sisson, M Mendez, K Choi, N Subbotina, A Courey, A Cunningham, ...
American journal of respiratory and critical care medicine 181 (3), 254-263, 2010
Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus
D Duan, Y Yue, Z Yan, J Yang, JF Engelhardt
The Journal of clinical investigation 105 (11), 1573-1587, 2000
CD4 (+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver.
RM Zwacka, Y Zhang, J Halldorson, H Schlossberg, L Dudus, ...
The Journal of clinical investigation 100 (2), 279-289, 1997
Airway epithelial cells: current concepts and challenges
RG Crystal, SH Randell, JF Engelhardt, J Voynow, ME Sunday
Proceedings of the American Thoracic Society 5 (7), 772-777, 2008
SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model
MM Harraz, JJ Marden, W Zhou, Y Zhang, A Williams, VS Sharov, ...
The Journal of clinical investigation 118 (2), 659-670, 2008
Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans
BR Grubb, RJ Pickles, H Ye, JR Yankaskas, RN Vick, JF Engelhardt, ...
Nature 371 (6500), 802-806, 1994
Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study
RH Simon, JF Engelhardt, Y Yang, M Zepeda, S Weber-Pendleton, ...
Human gene therapy 4 (6), 771-780, 1993
Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis
X Sun, H Sui, JT Fisher, Z Yan, X Liu, HJ Cho, NS Joo, Y Zhang, W Zhou, ...
The Journal of clinical investigation 120 (9), 3149-3160, 2010
Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1–deleted adenoviruses
JF Engelhardt, Y Yang, LD Stratford-Perricaudet, ED Allen, K Kozarsky, ...
Nature genetics 4 (1), 27-34, 1993
Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and phosphatidylinositol-3 kinase activation
S Sanlioglu, PK Benson, J Yang, EM Atkinson, T Reynolds, JF Engelhardt
Journal of virology 74 (19), 9184-9196, 2000
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