| Towards a proteome-scale map of the human protein–protein interaction network JF Rual, K Venkatesan, T Hao, T Hirozane-Kishikawa, A Dricot, N Li, ... Nature 437 (7062), 1173-1178, 2005 | 3530 | 2005 |
| A map of the interactome network of the metazoan C. elegans S Li, CM Armstrong, N Bertin, H Ge, S Milstein, M Boxem, PO Vidalain, ... Science 303 (5657), 540-543, 2004 | 2194 | 2004 |
| Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing JK Nair, JLS Willoughby, A Chan, K Charisse, MR Alam, Q Wang, ... Journal of the American Chemical Society 136 (49), 16958-16961, 2014 | 1008 | 2014 |
| Therapeutic siRNA silencing in inflammatory monocytes in mice F Leuschner, P Dutta, R Gorbatov, TI Novobrantseva, JS Donahoe, ... Nature biotechnology 29 (11), 1005-1010, 2011 | 857 | 2011 |
| A conserved checkpoint pathway mediates DNA damage–induced apoptosis and cell cycle arrest in C. elegans A Gartner, S Milstein, S Ahmed, J Hodgkin, MO Hengartner Molecular cell 5 (3), 435-443, 2000 | 578 | 2000 |
| Edgetic perturbation models of human inherited disorders Q Zhong, N Simonis, QR Li, B Charloteaux, F Heuze, N Klitgord, S Tam, ... Molecular systems biology 5 (1), 321, 2009 | 408 | 2009 |
| Acetyl CoA carboxylase inhibition reduces hepatic steatosis but elevates plasma triglycerides in mice and humans: a bedside to bench investigation CW Kim, C Addy, J Kusunoki, NN Anderson, S Deja, X Fu, SC Burgess, ... Cell metabolism 26 (2), 394-406. e6, 2017 | 375 | 2017 |
| Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network N Simonis, JF Rual, AR Carvunis, M Tasan, I Lemmens, ... Nature methods 6 (1), 47-54, 2009 | 338 | 2009 |
| hORFeome v3. 1: a resource of human open reading frames representing over 10,000 human genes P Lamesch, N Li, S Milstein, C Fan, T Hao, G Szabo, Z Hu, K Venkatesan, ... Genomics 89 (3), 307-315, 2007 | 316 | 2007 |
| Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis ER Hofmann, S Milstein, SJ Boulton, M Ye, JJ Hofmann, L Stergiou, ... Current biology 12 (22), 1908-1918, 2002 | 303 | 2002 |
| An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia A Sehgal, S Barros, L Ivanciu, B Cooley, J Qin, T Racie, J Hettinger, ... Nature medicine 21 (5), 492-497, 2015 | 291 | 2015 |
| A protein domain-based interactome network for C. elegans early embryogenesis M Boxem, Z Maliga, N Klitgord, N Li, I Lemmens, M Mana, ... Cell 134 (3), 534-545, 2008 | 242 | 2008 |
| Advanced siRNA designs further improve in vivo performance of GalNAc-siRNA conjugates DJ Foster, CR Brown, S Shaikh, C Trapp, MK Schlegel, K Qian, A Sehgal, ... Molecular Therapy 26 (3), 708-717, 2018 | 237 | 2018 |
| An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe−/− mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia PJ Schmidt, I Toudjarska, AK Sendamarai, T Racie, S Milstein, ... Blood, The Journal of the American Society of Hematology 121 (7), 1200-1208, 2013 | 209 | 2013 |
| siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in … S Matsuda, K Keiser, JK Nair, K Charisse, RM Manoharan, P Kretschmer, ... ACS chemical biology 10 (5), 1181-1187, 2015 | 208 | 2015 |
| Hepatocyte‐Specific Delivery of siRNAs Conjugated to Novel Non‐nucleosidic Trivalent N‐Acetylgalactosamine Elicits Robust Gene Silencing in Vivo KG Rajeev, JK Nair, M Jayaraman, K Charisse, N Taneja, J O'Shea, ... ChemBioChem 16 (6), 903-908, 2015 | 189 | 2015 |
| Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-β signaling network M Tewari, PJ Hu, JS Ahn, N Ayivi-Guedehoussou, PO Vidalain, S Li, ... Molecular cell 13 (4), 469-482, 2004 | 167 | 2004 |
| C. elegans ORFeome version 3.1: increasing the coverage of ORFeome resources with improved gene predictions P Lamesch, S Milstein, T Hao, J Rosenberg, N Li, R Sequerra, S Bosak, ... Genome research 14 (10b), 2064-2069, 2004 | 142 | 2004 |
| Systemic RNAi-mediated gene silencing in nonhuman primate and rodent myeloid cells TI Novobrantseva, A Borodovsky, J Wong, B Klebanov, M Zafari, K Yucius, ... Molecular Therapy-Nucleic Acids 1, 2012 | 138 | 2012 |
| Preclinical development of a subcutaneous ALAS1 RNAi therapeutic for treatment of hepatic porphyrias using circulating RNA quantification A Chan, A Liebow, M Yasuda, L Gan, T Racie, M Maier, S Kuchimanchi, ... Molecular Therapy-Nucleic Acids 4, 2015 | 130 | 2015 |
