| Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling JW Thornton, E Need, D Crews Science 301 (5640), 1714-1717, 2003 | 774 | 2003 |
| Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions JW Thornton Proceedings of the National Academy of Sciences 98 (10), 5671-5676, 2001 | 749 | 2001 |
| Evolution of hormone-receptor complexity by molecular exploitation JT Bridgham, SM Carroll, JW Thornton Science 312 (5770), 97-101, 2006 | 687 | 2006 |
| Performance of maximum parsimony and likelihood phylogenetics when evolution is heterogeneous B Kolaczkowski, JW Thornton Nature 431 (7011), 980-984, 2004 | 673 | 2004 |
| Identification of a third distinct estrogen receptor and reclassification of estrogen receptors in teleosts MB Hawkins, JW Thornton, D Crews, JK Skipper, A Dotte, P Thomas Proceedings of the National Academy of Sciences 97 (20), 10751-10756, 2000 | 613 | 2000 |
| Crystal structure of an ancient protein: evolution by conformational epistasis EA Ortlund, JT Bridgham, MR Redinbo, JW Thornton Science 317 (5844), 1544-1548, 2007 | 498 | 2007 |
| Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1 IN Krylova, EP Sablin, J Moore, RX Xu, GM Waitt, JA MacKay, ... Cell 120 (3), 343-355, 2005 | 482 | 2005 |
| Epistasis in protein evolution TN Starr, JW Thornton Protein Science 25 (7), 1204-1218, 2016 | 455 | 2016 |
| An epistatic ratchet constrains the direction of glucocorticoid receptor evolution JT Bridgham, EA Ortlund, JW Thornton Nature 461 (7263), 515-519, 2009 | 447 | 2009 |
| Resurrecting ancient genes: experimental analysis of extinct molecules JW Thornton Nature Reviews Genetics 5 (5), 366-375, 2004 | 442 | 2004 |
| Mechanistic approaches to the study of evolution: the functional synthesis AM Dean, JW Thornton Nature Reviews Genetics 8 (9), 675-688, 2007 | 406 | 2007 |
| Evolutionary biochemistry: revealing the historical and physical causes of protein properties MJ Harms, JW Thornton Nature Reviews Genetics 14 (8), 559-571, 2013 | 361 | 2013 |
| Pandora's Poison: Chlorine, Health, and a New Environmental Strategy J Thornton MIT Press, 2000 | 331 | 2000 |
| GENE FAMILY EVOLUTION AND HOMOLOGY: Genomics Meets Phylogenetics JW Thornton, R DeSalle Annual review of genomics and human genetics 1 (1), 41-73, 2000 | 269 | 2000 |
| Analyzing protein structure and function using ancestral gene reconstruction MJ Harms, JW Thornton Current opinion in structural biology 20 (3), 360-366, 2010 | 259 | 2010 |
| Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor JT Bridgham, GN Eick, C Larroux, K Deshpande, MJ Harms, ... PLoS biology 8 (10), e1000497, 2010 | 256 | 2010 |
| Evolution of increased complexity in a molecular machine GC Finnigan, V Hanson-Smith, TH Stevens, JW Thornton Nature 481 (7381), 360-364, 2012 | 245 | 2012 |
| The interface of protein structure, protein biophysics, and molecular evolution DA Liberles, SA Teichmann, I Bahar, U Bastolla, J Bloom, ... Protein Science 21 (6), 769-785, 2012 | 227 | 2012 |
| The Octopus vulgaris Estrogen Receptor Is a Constitutive Transcriptional Activator: Evolutionary and Functional Implications J Keay, JT Bridgham, JW Thornton Endocrinology 147 (8), 3861-3869, 2006 | 227 | 2006 |
| Robustness of ancestral sequence reconstruction to phylogenetic uncertainty V Hanson-Smith, B Kolaczkowski, JW Thornton Molecular biology and evolution 27 (9), 1988-1999, 2010 | 197 | 2010 |
