| Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies IJ Holt, AE Harding, JA Morgan-Hughes nature 331 (6158), 717-719, 1988 | 2213 | 1988 |
| A new mitochondrial disease associated with mitochondrial DNA heteroplasmy. IJ Holt, AE Harding, RK Petty, JA Morgan-Hughes American journal of human genetics 46 (3), 428, 1990 | 1202 | 1990 |
| Coupled leading-and lagging-strand synthesis of mammalian mitochondrial DNA IJ Holt, HE Lorimer, HT Jacobs Cell 100 (5), 515-524, 2000 | 556 | 2000 |
| Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development MAM Reijns, B Rabe, RE Rigby, P Mill, KR Astell, LA Lettice, S Boyle, ... Cell 149 (5), 1008-1022, 2012 | 450 | 2012 |
| Blue Native electrophoresis to study mitochondrial and other protein complexes LGJ Nijtmans, NS Henderson, IJ Holt Methods 26 (4), 327-334, 2002 | 415 | 2002 |
| Minimizing the damage: repair pathways keep mitochondrial DNA intact L Kazak, A Reyes, IJ Holt Nature reviews Molecular cell biology 13 (10), 659-671, 2012 | 405 | 2012 |
| PrimPol, an archaic primase/polymerase operating in human cells S García-Gómez, A Reyes, MI Martínez-Jiménez, ES Chocrón, S Mourón, ... Molecular cell 52 (4), 541-553, 2013 | 365 | 2013 |
| Mitochondrial myopathies: clinical and biochemical features of 30 patients with major deletions of muscle mitochondrial DNA IJ Holt, AE Harding, JM Cooper, AHV Schapira, A Toscano, JB Clark, ... Annals of Neurology: Official Journal of the American Neurological …, 1989 | 360 | 1989 |
| Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication MY Yang, M Bowmaker, A Reyes, L Vergani, P Angeli, E Gringeri, ... Cell 111 (4), 495-505, 2002 | 343 | 2002 |
| Pearson syndrome and mitochondrial encephalomyopathy in a patient with a deletion of mtDNA. MA McShane, SR Hammans, M Sweeney, IJ Holt, TJ Beattie, EM Brett, ... American journal of human genetics 48 (1), 39, 1991 | 315 | 1991 |
| Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand T Yasukawa, A Reyes, TJ Cluett, MY Yang, M Bowmaker, HT Jacobs, ... The EMBO journal 25 (22), 5358-5371, 2006 | 311 | 2006 |
| Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone M Bowmaker, MY Yang, T Yasukawa, A Reyes, HT Jacobs, JA Huberman, ... Journal of Biological Chemistry 278 (51), 50961-50969, 2003 | 288 | 2003 |
| Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number H Tyynismaa, H Sembongi, M Bokori-Brown, C Granycome, N Ashley, ... Human molecular genetics 13 (24), 3219-3227, 2004 | 275 | 2004 |
| The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization J He, CC Mao, A Reyes, H Sembongi, M Di Re, C Granycome, ... The Journal of cell biology 176 (2), 141-146, 2007 | 241 | 2007 |
| Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes. DR Dunbar, PA Moonie, HT Jacobs, IJ Holt Proceedings of the National Academy of Sciences 92 (14), 6562-6566, 1995 | 239 | 1995 |
| Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication JM Fusté, S Wanrooij, E Jemt, CE Granycome, TJ Cluett, Y Shi, ... Molecular cell 37 (1), 67-78, 2010 | 223 | 2010 |
| Human mitochondrial DNA replication IJ Holt, A Reyes Cold Spring Harbor perspectives in biology 4 (12), a012971, 2012 | 212 | 2012 |
| A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA T Yasukawa, MY Yang, HT Jacobs, IJ Holt Molecular cell 18 (6), 651-662, 2005 | 212 | 2005 |
| Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis J He, HM Cooper, A Reyes, M Di Re, H Sembongi, TR Litwin, J Gao, ... Nucleic acids research 40 (13), 6109-6121, 2012 | 194 | 2012 |
| Genetic heterogeneity and mitochondrial DNA heteroplasmy in Leber's hereditary optic neuropathy. IJ Holt, DH Miller, AE Harding Journal of medical genetics 26 (12), 739-743, 1989 | 192 | 1989 |
Antonella SpinazzolaUCL Institute of NeurologyVerified email at ucl.ac.uk
