Siderophores from neighboring organisms promote the growth of uncultured bacteria A D'Onofrio, JM Crawford, EJ Stewart, K Witt, E Gavrish, S Epstein, ... Chemistry & biology 17 (3), 254-264, 2010 | 531 | 2010 |
A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology H Chen, PK Nwe, Y Yang, CE Rosen, AA Bielecka, M Kuchroo, GW Cline, ... Cell 177 (5), 1217-1231. e18, 2019 | 249 | 2019 |
Deconstruction of iterative multidomain polyketide synthase function JM Crawford, PM Thomas, JR Scheerer, AL Vagstad, NL Kelleher, ... Science 320 (5873), 243-246, 2008 | 247 | 2008 |
The colibactin warhead crosslinks DNA MI Vizcaino, JM Crawford Nature chemistry 7 (5), 411-417, 2015 | 244 | 2015 |
New insights into the formation of fungal aromatic polyketides JM Crawford, CA Townsend Nature Reviews Microbiology 8 (12), 879-889, 2010 | 244 | 2010 |
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase JM Crawford, BCR Dancy, EA Hill, DW Udwary, CA Townsend Proceedings of the National Academy of Sciences 103 (45), 16728-16733, 2006 | 219 | 2006 |
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization JM Crawford, TP Korman, JW Labonte, AL Vagstad, EA Hill, ... Nature 461 (7267), 1139-1143, 2009 | 206 | 2009 |
Small molecule perimeter defense in entomopathogenic bacteria JM Crawford, C Portmann, X Zhang, MBJ Roeffaers, J Clardy Proceedings of the National Academy of Sciences 109 (27), 10821-10826, 2012 | 185 | 2012 |
Structure elucidation of colibactin and its DNA cross-links M Xue, CS Kim, AR Healy, KM Wernke, Z Wang, MC Frischling, EE Shine, ... Science 365 (6457), eaax2685, 2019 | 183 | 2019 |
Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior CN Fischer, EP Trautman, JM Crawford, EV Stabb, J Handelsman, ... Elife 6, e18855, 2017 | 157 | 2017 |
Bacterial symbionts and natural products JM Crawford, J Clardy Chemical communications 47 (27), 7559-7566, 2011 | 154 | 2011 |
Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules MI Vizcaino, P Engel, E Trautman, JM Crawford Journal of the American Chemical Society 136 (26), 9244-9247, 2014 | 132 | 2014 |
A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states VS Somvanshi, RE Sloup, JM Crawford, AR Martin, AJ Heidt, K Kim, ... Science 337 (6090), 88-93, 2012 | 130 | 2012 |
Regulating alternative lifestyles in entomopathogenic bacteria JM Crawford, R Kontnik, J Clardy Current Biology 20 (1), 69-74, 2010 | 127 | 2010 |
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis TP Korman, JM Crawford, JW Labonte, AG Newman, J Wong, ... Proceedings of the National Academy of Sciences 107 (14), 6246-6251, 2010 | 121 | 2010 |
Characterization of Autoinducer-3 Structure and Biosynthesis in E. coli CS Kim, A Gatsios, S Cuesta, YC Lam, Z Wei, H Chen, RM Russell, ... ACS central science 6 (2), 197-206, 2020 | 114 | 2020 |
A community resource for paired genomic and metabolomic data mining MA Schorn, S Verhoeven, L Ridder, F Huber, DD Acharya, AA Aksenov, ... Nature Chemical Biology 17 (4), 363-368, 2021 | 101 | 2021 |
Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites Y Cao, J Oh, M Xue, WJ Huh, J Wang, JA Gonzalez-Hernandez, TA Rice, ... Science 378 (6618), eabm3233, 2022 | 88 | 2022 |
Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways P Engel, MI Vizcaino, JM Crawford Applied and environmental microbiology 81 (4), 1502-1512, 2015 | 82 | 2015 |
A mechanistic model for colibactin-induced genotoxicity AR Healy, H Nikolayevskiy, JR Patel, JM Crawford, SB Herzon Journal of the American Chemical Society 138 (48), 15563-15570, 2016 | 80 | 2016 |