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Leon J. De Windt
Leon J. De Windt
Professor of Molecular Cardiology at Maastricht University, The Netherlands
Geverifieerd e-mailadres voor maastrichtuniversity.nl
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The MEK1–ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
OF Bueno, LJ De Windt, KM Tymitz, SA Witt, TR Kimball, R Klevitsky, ...
The EMBO journal 19 (23), 6341-6350, 2000
9222000
MiR423-5p as a circulating biomarker for heart failure
AJ Tijsen, EE Creemers, PD Moerland, LJ de Windt, AC van der Wal, ...
Circulation research 106 (6), 1035-1039, 2010
7592010
The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo
Q Liang, LJ De Windt, SA Witt, TR Kimball, BE Markham, JD Molkentin
Journal of Biological Chemistry 276 (32), 30245-30253, 2001
4262001
Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy
T Taigen, LJ De Windt, HW Lim, JD Molkentin
Proceedings of the National Academy of Sciences 97 (3), 1196-1201, 2000
4242000
Myocyte apoptosis in heart failure
VPM van Empel, ATA Bertrand, L Hofstra, HJ Crijns, PA Doevendans, ...
Cardiovascular research 67 (1), 21-29, 2005
3872005
MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling
PA da Costa Martins, K Salic, MM Gladka, AS Armand, S Leptidis, ...
Nature cell biology 12 (12), 1220-1227, 2010
3752010
A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression
U Delling, J Tureckova, HW Lim, LJ De Windt, P Rotwein, JD Molkentin
Molecular and cellular biology 20 (17), 6600-6611, 2000
3532000
Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process
WA Den Hengst, JF Gielis, JY Lin, PE Van Schil, LJ De Windt, AL Moens
American Journal of Physiology-Heart and Circulatory Physiology, 2010
3442010
Conditional Dicer Gene Deletion in the Postnatal Myocardium Provokes Spontaneous Cardiac Remodeling
PA da Costa Martins, M Bourajjaj, M Gladka, M Kortland, RJ van Oort, ...
Circulation 118 (15), 1567-1576, 2008
3432008
Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth
BJ Wilkins, LJ De Windt, OF Bueno, JC Braz, BJ Glascock, TF Kimball, ...
Molecular and cellular biology 22 (21), 7603-7613, 2002
3172002
Long noncoding RNA Chast promotes cardiac remodeling
J Viereck, R Kumarswamy, A Foinquinos, K Xiao, P Avramopoulos, ...
Science translational medicine 8 (326), 326ra22-326ra22, 2016
2942016
Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart: cross-talk between cardiac hypertrophic signaling pathways
LJ De Windt, HW Lim, S Haq, T Force, JD Molkentin
Journal of Biological Chemistry 275 (18), 13571-13579, 2000
2922000
Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: an apoptosis-independent model of dilated heart failure
LJ De Windt, HW Lim, T Taigen, D Wencker, G Condorelli, GW Dorn, ...
Circulation research 86 (3), 255-263, 2000
2902000
Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy
R Roncarati, C Viviani Anselmi, MA Losi, L Papa, E Cavarretta, ...
Journal of the American College of Cardiology 63 (9), 920-927, 2014
2842014
Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo
LJ De Windt, HW Lim, OF Bueno, Q Liang, U Delling, JC Braz, ...
Proceedings of the National Academy of Sciences 98 (6), 3322-3327, 2001
2752001
MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo
DJ Lips, OF Bueno, BJ Wilkins, NH Purcell, RA Kaiser, JN Lorenz, ...
Circulation 109 (16), 1938-1941, 2004
2672004
Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy
DJ Lips, LJ deWindt, DJW van Kraaij, PA Doevendans
European heart journal 24 (10), 883-896, 2003
2542003
PKCα regulates the hypertrophic growth of cardiomyocytes through extracellular signal–regulated kinase1/2 (ERK1/2)
JC Braz, OF Bueno, LJ De Windt, JD Molkentin
The Journal of cell biology 156 (5), 905-919, 2002
2532002
Regulation of fetal gene expression in heart failure
E Dirkx, PA da Costa Martins, LJ De Windt
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (12 …, 2013
2462013
MicroRNAs in heart failure: from biomarker to target for therapy
EL Vegter, P van der Meer, LJ de Windt, YM Pinto, AA Voors
European journal of heart failure 18 (5), 457-468, 2016
2422016
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