Robert Yauch
Robert Yauch
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Efficacy and safety of vismodegib in advanced basal-cell carcinoma
A Sekulic, MR Migden, AE Oro, L Dirix, KD Lewis, JD Hainsworth, ...
New England Journal of Medicine 366 (23), 2171-2179, 2012
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
DD Von Hoff, PM LoRusso, CM Rudin, JC Reddy, RL Yauch, R Tibes, ...
New England Journal of Medicine 361 (12), 1164-1172, 2009
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
CM Rudin, CL Hann, J Laterra, RL Yauch, CA Callahan, L Fu, T Holcomb, ...
New England Journal of Medicine 361 (12), 1173-1178, 2009
A paracrine requirement for hedgehog signalling in cancer
RL Yauch, SE Gould, SJ Scales, T Tang, H Tian, CP Ahn, D Marshall, ...
Nature 455 (7211), 406-410, 2008
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
CM Rudin, S Durinck, EW Stawiski, JT Poirier, Z Modrusan, DS Shames, ...
Nature genetics 44 (10), 1111-1116, 2012
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
RL Yauch, GJP Dijkgraaf, B Alicke, T Januario, CP Ahn, T Holcomb, ...
Science 326 (5952), 572-574, 2009
Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading
SD Miller, CL Vanderlugt, WS Begolka, W Pao, RL Yauch, KL Neville, ...
Nature medicine 3 (10), 1133-1136, 1997
Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients
RL Yauch, T Januario, DA Eberhard, G Cavet, W Zhu, L Fu, TQ Pham, ...
Clinical Cancer Research 11 (24), 8686-8698, 2005
Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome
JY Tang, JM Mackay-Wiggan, M Aszterbaum, RL Yauch, J Lindgren, ...
New England Journal of Medicine 366 (23), 2180-2188, 2012
A comprehensive transcriptional portrait of human cancer cell lines
C Klijn, S Durinck, EW Stawiski, PM Haverty, Z Jiang, H Liu, J Degenhardt, ...
Nature biotechnology 33 (3), 306-312, 2015
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
M Ohh, RL Yauch, KM Lonergan, JM Whaley, AO Stemmer-Rachamimov, ...
Molecular cell 1 (7), 959-968, 1998
Somatic mutations lead to an oncogenic deletion of met in lung cancer
M Kong-Beltran, S Seshagiri, J Zha, W Zhu, K Bhawe, N Mendoza, ...
Cancer research 66 (1), 283-289, 2006
Randomized phase II trial of onartuzumab in combination with erlotinib in patients with advanced non–small-cell lung cancer
DR Spigel, TJ Ervin, RA Ramlau, DB Daniel, JH Goldschmidt Jr, ...
Journal of clinical oncology 31 (32), 4105, 2013
Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug ResistanceMechanisms of Resistance to a Hedgehog Pathway Inhibitor
GJP Dijkgraaf, B Alicke, L Weinmann, T Januario, K West, Z Modrusan, ...
Cancer research 71 (2), 435-444, 2011
Highly stoichiometric, stable, and specific association of integrin α3β1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration
RL Yauch, F Berditchevski, MB Harler, J Reichner, ME Hemler
Molecular biology of the cell 9 (10), 2751-2765, 1998
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma
HJ Sharpe, G Pau, GJ Dijkgraaf, N Basset-Seguin, Z Modrusan, ...
Cancer cell 27 (3), 327-341, 2015
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice
J Lau, J Cheung, A Navarro, S Lianoglou, B Haley, K Totpal, L Sanders, ...
Nature communications 8 (1), 14572, 2017
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors
A Daemen, D Peterson, N Sahu, R McCord, X Du, B Liu, K Kowanetz, ...
Proceedings of the National Academy of Sciences 112 (32), E4410-E4417, 2015
Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC.
DR Spigel, TJ Ervin, R Ramlau, DB Daniel, JH Goldschmidt, ...
Journal of Clinical Oncology 29 (15_suppl), 7505-7505, 2011
Reproducible pharmacogenomic profiling of cancer cell line panels
PM Haverty, E Lin, J Tan, Y Yu, B Lam, S Lianoglou, RM Neve, S Martin, ...
Nature 533 (7603), 333-337, 2016
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