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Dr. Michaela Gack
Dr. Michaela Gack
Scientific Director and Chair, Cleveland Clinic Florida Research and Innovation Center
Geverifieerd e-mailadres voor ccf.org
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
107102021
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
MU Gack, YC Shin, CH Joo, T Urano, C Liang, L Sun, O Takeuchi, S Akira, ...
Nature 446 (7138), 916-920, 2007
18332007
RIG-I-like receptors: their regulation and roles in RNA sensing
J Rehwinkel, MU Gack
Nature Reviews Immunology 20 (9), 537-551, 2020
10732020
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
MU Gack, RA Albrecht, T Urano, KS Inn, IC Huang, E Carnero, M Farzan, ...
Cell host & microbe 5 (5), 439-449, 2009
10022009
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
C Liang, J Lee, KS Inn, MU Gack, Q Li, EA Roberts, I Vergne, V Deretic, ...
Nature cell biology 10 (7), 776-787, 2008
9372008
Dysregulation of type I interferon responses in COVID-19
D Acharya, GQ Liu, MU Gack
Nature Reviews Immunology 20 (7), 397-398, 2020
4642020
Viral evasion of intracellular DNA and RNA sensing
YK Chan, MU Gack
Nature Reviews Microbiology 14 (6), 360-373, 2016
4622016
Cytosolic viral sensor RIG-I is a 5'-Triphosphate–dependent translocase on double-stranded RNA
S Myong, S Cui, PV Cornish, A Kirchhofer, MU Gack, JU Jung, ...
Science 323 (5917), 1070-1074, 2009
4472009
Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein
R Rajsbaum, RA Albrecht, MK Wang, NP Maharaj, GA Versteeg, ...
PLoS pathogens 8 (11), e1003059, 2012
3372012
Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling
E Wies, MK Wang, NP Maharaj, K Chen, S Zhou, RW Finberg, MU Gack
Immunity 38 (3), 437-449, 2013
3322013
Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction
MU Gack, A Kirchhofer, YC Shin, KS Inn, C Liang, S Cui, S Myong, T Ha, ...
Proceedings of the National Academy of Sciences 105 (43), 16743-16748, 2008
3072008
TRIM proteins and their roles in antiviral host defenses
M van Gent, KMJ Sparrer, MU Gack
Annual review of virology 5, 385-405, 2018
2532018
Linear ubiquitin assembly complex negatively regulates RIG-I-and TRIM25-mediated type I interferon induction
KS Inn, MU Gack, F Tokunaga, M Shi, LY Wong, K Iwai, JU Jung
Molecular cell 41 (3), 354-365, 2011
2242011
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
GQ Liu, JH Lee, ZM Parker, D Acharya, JJ Chiang, M van Gent, W Riedl, ...
Nature microbiology 6 (4), 467-478, 2021
2102021
Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity
JJ Chiang, KMJ Sparrer, M van Gent, C Lässig, T Huang, N Osterrieder, ...
Nature immunology 19 (1), 53-62, 2018
2102018
A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19
Y Zhou, Y Hou, J Shen, R Mehra, A Kallianpur, DA Culver, MU Gack, ...
PLoS biology 18 (11), e3000970, 2020
1892020
RIG-I-like receptor regulation in virus infection and immunity
YK Chan, MU Gack
Current opinion in virology 12, 7-14, 2015
1802015
Ubiquitination in the antiviral immune response
ME Davis, MU Gack
Virology 479, 52-65, 2015
1802015
TRIM23 mediates virus-induced autophagy via activation of TBK1
KMJ Sparrer, S Gableske, MA Zurenski, ZM Parker, F Full, GJ Baumgart, ...
Nature microbiology 2 (11), 1543-1557, 2017
1692017
The ubiquitin-specific protease USP15 promotes RIG-I–mediated antiviral signaling by deubiquitylating TRIM25
EK Pauli, YK Chan, ME Davis, S Gableske, MK Wang, KF Feister, ...
Science signaling 7 (307), ra3-ra3, 2014
1622014
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Artikelen 1–20