|Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients|
G Schwank, BK Koo, V Sasselli, JF Dekkers, I Heo, T Demircan, N Sasaki, ...
Cell stem cell 13 (6), 653-658, 2013
|Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling|
W De Lau, N Barker, TY Low, BK Koo, VSW Li, H Teunissen, P Kujala, ...
Nature 476 (7360), 293-297, 2011
|Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors|
BK Koo, M Spit, I Jordens, TY Low, DE Stange, M Van De Wetering, ...
Nature 488 (7413), 665-669, 2012
|The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+ 4’cell markers|
J Muņoz, DE Stange, AG Schepers, M Van De Wetering, BK Koo, ...
The EMBO journal 31 (14), 3079-3091, 2012
|Human primary liver cancer–derived organoid cultures for disease modeling and drug screening|
L Broutier, G Mastrogiovanni, MMA Verstegen, HE Francies, LM Gavarrķ, ...
Nature medicine 23 (12), 1424, 2017
|Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium|
DE Stange, BK Koo, M Huch, G Sibbel, O Basak, A Lyubimova, P Kujala, ...
Cell 155 (2), 357-368, 2013
|Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation|
L Broutier, A Andersson-Rolf, CJ Hindley, SF Boj, H Clevers, BK Koo, ...
Nature protocols 11 (9), 1724, 2016
|Controlled gene expression in primary Lgr5 organoid cultures|
BK Koo, DE Stange, T Sato, W Karthaus, HF Farin, M Huch, JH Van Es, ...
Nature methods 9 (1), 81-83, 2012
|Modeling mouse and human development using organoid cultures|
M Huch, BK Koo
Development 142 (18), 3113-3125, 2015
|Mind bomb 1 is essential for generating functional Notch ligands to activate Notch|
BK Koo, HS Lim, R Song, MJ Yoon, KJ Yoon, JS Moon, YW Kim, M Kwon, ...
Development 132 (15), 3459-3470, 2005
|A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal|
JH van Es, A Haegebarth, P Kujala, S Itzkovitz, BK Koo, SF Boj, J Korving, ...
Molecular and cellular biology 32 (10), 1918-1927, 2012
|A crucial role of WW45 in developing epithelial tissues in the mouse|
JH Lee, TS Kim, TH Yang, BK Koo, SP Oh, KP Lee, HJ Oh, SH Lee, ...
The EMBO journal 27 (8), 1231-1242, 2008
|Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts|
J Schuijers, JP Junker, M Mokry, P Hatzis, BK Koo, V Sasselli, ...
Cell stem cell 16 (2), 158-170, 2015
|Mind bomb 1-expressing intermediate progenitors generate notch signaling to maintain radial glial cells|
KJ Yoon, BK Koo, SK Im, HW Jeong, J Ghim, M Kwon, JS Moon, T Miyata, ...
Neuron 58 (4), 519-531, 2008
|ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response|
J Heijmans, JFL de Jeude, BK Koo, SL Rosekrans, MCB Wielenga, ...
Cell reports 3 (4), 1128-1139, 2013
|Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium|
MY Turco, L Gardner, J Hughes, T Cindrova-Davies, MJ Gomez, L Farrell, ...
Nature cell biology 19 (5), 568-577, 2017
|Receptor activator of NF-κB ligand regulates the proliferation of mammary epithelial cells via Id2|
NS Kim, HJ Kim, BK Koo, MC Kwon, YW Kim, Y Cho, Y Yokota, ...
Molecular and cellular biology 26 (3), 1002-1013, 2006
|Defective Notch activation in microenvironment leads to myeloproliferative disease|
YW Kim, BK Koo, HW Jeong, MJ Yoon, R Song, J Shin, DC Jeong, ...
Blood 112 (12), 4628-4638, 2008
|Stem cells marked by the R-spondin receptor LGR5|
BK Koo, H Clevers
Gastroenterology 147 (2), 289-302, 2014
|Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer|
HA Kim, BK Koo, JH Cho, YY Kim, J Seong, HJ Chang, YM Oh, ...
The Journal of clinical investigation 122 (9), 3248-3259, 2012