| Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients G Schwank, BK Koo, V Sasselli, JF Dekkers, I Heo, T Demircan, N Sasaki, ... Cell stem cell 13 (6), 653-658, 2013 | 1530 | 2013 |
| Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling W De Lau, N Barker, TY Low, BK Koo, VSW Li, H Teunissen, P Kujala, ... Nature 476 (7360), 293-297, 2011 | 1335 | 2011 |
| Human organoids: model systems for human biology and medicine J Kim, BK Koo, JA Knoblich Nature Reviews Molecular Cell Biology 21 (10), 571-584, 2020 | 1218 | 2020 |
| Human primary liver cancer–derived organoid cultures for disease modeling and drug screening L Broutier, G Mastrogiovanni, MMA Verstegen, HE Francies, LM Gavarrķ, ... Nature medicine 23 (12), 1424-1435, 2017 | 1031 | 2017 |
| Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors BK Koo, M Spit, I Jordens, TY Low, DE Stange, M Van De Wetering, ... Nature 488 (7413), 665-669, 2012 | 929 | 2012 |
| The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+ 4’cell markers J Muņoz, DE Stange, AG Schepers, M Van De Wetering, BK Koo, ... The EMBO journal 31 (14), 3079-3091, 2012 | 793 | 2012 |
| Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation L Broutier, A Andersson-Rolf, CJ Hindley, SF Boj, H Clevers, BK Koo, ... Nature protocols 11 (9), 1724-1743, 2016 | 596 | 2016 |
| Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium DE Stange, BK Koo, M Huch, G Sibbel, O Basak, A Lyubimova, P Kujala, ... Cell 155 (2), 357-368, 2013 | 497 | 2013 |
| Modeling mouse and human development using organoid cultures M Huch, BK Koo Development 142 (18), 3113-3125, 2015 | 494 | 2015 |
| Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium MY Turco, L Gardner, J Hughes, T Cindrova-Davies, MJ Gomez, L Farrell, ... Nature cell biology 19 (5), 568-577, 2017 | 492 | 2017 |
| Controlled gene expression in primary Lgr5 organoid cultures BK Koo, DE Stange, T Sato, W Karthaus, HF Farin, M Huch, JH Van Es, ... Nature methods 9 (1), 81-83, 2012 | 345 | 2012 |
| A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal JH van Es, A Haegebarth, P Kujala, S Itzkovitz, BK Koo, SF Boj, J Korving, ... Molecular and cellular biology 32 (10), 1918-1927, 2012 | 281 | 2012 |
| Inflammatory signals induce AT2 cell-derived damage-associated transient progenitors that mediate alveolar regeneration J Choi, JE Park, G Tsagkogeorga, M Yanagita, BK Koo, N Han, JH Lee Cell stem cell 27 (3), 366-382. e7, 2020 | 278 | 2020 |
| Mind bomb 1 is essential for generating functional Notch ligands to activate Notch BK Koo, HS Lim, R Song, MJ Yoon, KJ Yoon, JS Moon, YW Kim, M Kwon, ... Oxford University Press for The Company of Biologists Limited 132 (15), 3459 …, 2005 | 277 | 2005 |
| Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts J Schuijers, JP Junker, M Mokry, P Hatzis, BK Koo, V Sasselli, ... Cell stem cell 16 (2), 158-170, 2015 | 266 | 2015 |
| ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response J Heijmans, JFL de Jeude, BK Koo, SL Rosekrans, MCB Wielenga, ... Cell reports 3 (4), 1128-1139, 2013 | 247 | 2013 |
| DNA methylation and transcription patterns in intestinal epithelial cells from pediatric patients with inflammatory bowel diseases differentiate disease subtypes and associate … KJ Howell, J Kraiczy, KM Nayak, M Gasparetto, A Ross, C Lee, TN Mak, ... Gastroenterology 154 (3), 585-598, 2018 | 239 | 2018 |
| Divergent routes toward Wnt and R-spondin niche independency during human gastric carcinogenesis K Nanki, K Toshimitsu, A Takano, M Fujii, M Shimokawa, Y Ohta, ... Cell 174 (4), 856-869. e17, 2018 | 230 | 2018 |
| Human gastric cancer modelling using organoids T Seidlitz, SR Merker, A Rothe, F Zakrzewski, C von Neubeck, ... Gut 68 (2), 207-217, 2019 | 227 | 2019 |
| A crucial role of WW45 in developing epithelial tissues in the mouse JH Lee, TS Kim, TH Yang, BK Koo, SP Oh, KP Lee, HJ Oh, SH Lee, ... The EMBO journal 27 (8), 1231-1242, 2008 | 221 | 2008 |
Hans CleversHubrecht Institute - UtrechtVerified email at hubrecht.eu
