Federico Forneris
Federico Forneris
Armenise-Harvard Laboratory, Department of Biology and Biotechnology, University of Pavia
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A novel mammalian flavin-dependent histone demethylase
A Karytinos, F Forneris, A Profumo, G Ciossani, E Battaglioli, C Binda, ...
Journal of Biological Chemistry 284 (26), 17775-17782, 2009
Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2
C Binda, S Valente, M Romanenghi, S Pilotto, R Cirilli, A Karytinos, ...
Journal of the American Chemical Society 132 (19), 6827-6833, 2010
Human histone demethylase LSD1 reads the histone code
F Forneris, C Binda, MA Vanoni, E Battaglioli, A Mattevi
Journal of Biological Chemistry 280 (50), 41360-41365, 2005
Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process
F Forneris, C Binda, MA Vanoni, A Mattevi, E Battaglioli
FEBS letters 579 (10), 2203-2207, 2005
Structural basis of LSD1-CoREST selectivity in histone H3 recognition
F Forneris, C Binda, A Adamo, E Battaglioli, A Mattevi
Journal of Biological Chemistry 282 (28), 20070-20074, 2007
Structures of C3b in complex with factors B and D give insight into complement convertase formation
F Forneris, D Ricklin, J Wu, A Tzekou, RS Wallace, JD Lambris, P Gros
Science 330 (6012), 1816-1820, 2010
LSD1: oxidative chemistry for multifaceted functions in chromatin regulation
F Forneris, C Binda, E Battaglioli, A Mattevi
Trends in biochemical sciences 33 (4), 181-189, 2008
ThermoFAD, a Thermofluor«‐adapted flavin ad hoc detection system for protein folding and ligand binding
F Forneris, R Orru, D Bonivento, LR Chiarelli, A Mattevi
The FEBS journal 276 (10), 2833-2840, 2009
Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9
MA Hadders, D Bubeck, P Roversi, S Hakobyan, F Forneris, BP Morgan, ...
Cell reports 1 (3), 200-207, 2012
Multiple pathways guide oxygen diffusion into flavoenzyme active sites
R Baron, C Riley, P Chenprakhon, K Thotsaporn, RT Winter, A Alfieri, ...
Proceedings of the National Academy of Sciences 106 (26), 10603-10608, 2009
Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system
C Zibetti, A Adamo, C Binda, F Forneris, E Toffolo, C Verpelli, E Ginelli, ...
Journal of Neuroscience 30 (7), 2521-2532, 2010
A highly specific mechanism of histone H3-K4 recognition by histone demethylase LSD1
F Forneris, C Binda, A Dall'Aglio, MW Fraaije, E Battaglioli, A Mattevi
Journal of Biological Chemistry 281 (46), 35289-35295, 2006
Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5
WC Peng, W de Lau, F Forneris, JCM Granneman, M Huch, H Clevers, ...
Cell reports 3 (6), 1885-1892, 2013
New roles of flavoproteins in molecular cell biology: histone demethylase LSD1 and chromatin
F Forneris, E Battaglioli, A Mattevi, C Binda
The FEBS journal 276 (16), 4304-4312, 2009
Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode
F Forneris, J Wu, X Xue, D Ricklin, Z Lin, G Sfyroera, A Tzekou, ...
The EMBO journal 35 (10), 1133-1149, 2016
Structural Analysis of the Catalytic Mechanism and Stereoselectivity in Streptomyces coelicolor Alditol Oxidase,
F Forneris, DPHM Heuts, M Delvecchio, S Rovida, MW Fraaije, A Mattevi
Biochemistry 47 (3), 978-985, 2008
Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation
S Pilotto, V Speranzini, M Tortorici, D Durand, A Fish, S Valente, ...
Proceedings of the National Academy of Sciences 112 (9), 2752-2757, 2015
Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses
X Xue, J Wu, D Ricklin, F Forneris, P Di Crescenzio, CQ Schmidt, ...
Nature structural & molecular biology 24 (8), 643-651, 2017
Enzymes without borders: mobilizing substrates, delivering products
F Forneris, A Mattevi
Science 321 (5886), 213-216, 2008
Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization
F Villa, P Capasso, M Tortorici, F Forneris, A De Marco, A Mattevi, ...
Proceedings of the National Academy of Sciences 106 (48), 20204-20209, 2009
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