Wang-Yong Yang
Wang-Yong Yang
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Discovery of a biomarker and lead small molecules to target r (GGGGCC)-associated defects in c9FTD/ALS
Z Su, Y Zhang, TF Gendron, PO Bauer, J Chew, WY Yang, E Fostvedt, ...
Neuron 83 (5), 1043-1050, 2014
Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome
D Colak, N Zaninovic, MS Cohen, Z Rosenwaks, WY Yang, J Gerhardt, ...
Science 343 (6174), 1002-1005, 2014
A Small Molecule That Targets r(CGG)exp and Improves Defects in Fragile X-Associated Tremor Ataxia Syndrome
MD Disney, B Liu, WY Yang, C Sellier, T Tran, N Charlet-Berguerand, ...
ACS chemical biology 7 (10), 1711-1718, 2012
Hybrids of amino acids and acetylenic DNA-photocleavers: optimising efficiency and selectivity for cancer phototherapy
B Breiner, K Kaya, S Roy, WY Yang, IV Alabugin
Organic & biomolecular chemistry 10 (20), 3974-3987, 2012
C-lysine conjugates: pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy
WY Yang, B Breiner, SV Kovalenko, C Ben, M Singh, SN LeGrand, ...
Journal of the American Chemical Society 131 (32), 11458-11470, 2009
Small molecule inhibition of miR-544 biogenesis disrupts adaptive responses to hypoxia by modulating ATM-mTOR signaling
CL Haga, SP Velagapudi, JR Strivelli, WY Yang, MD Disney, DG Phinney
ACS chemical biology 10 (10), 2267-2276, 2015
Inhibition of non-ATG translational events in cells via covalent small molecules targeting RNA
WY Yang, HD Wilson, SP Velagapudi, MD Disney
Journal of the American Chemical Society 137 (16), 5336-5345, 2015
The hairpin form of r (G4C2) exp in c9ALS/FTD is repeat-associated non-ATG translated and a target for bioactive small molecules
ZF Wang, A Ursu, JL Childs-Disney, R Guertler, WY Yang, V Bernat, ...
Cell chemical biology 26 (2), 179-190. e12, 2019
Design of a bioactive small molecule that targets r (AUUCU) repeats in spinocerebellar ataxia 10
WY Yang, R Gao, M Southern, PS Sarkar, MD Disney
Nature communications 7 (1), 1-11, 2016
Small Molecule Recognition and Tools to Study Modulation of r(CGG)exp in Fragile X-Associated Tremor Ataxia Syndrome
WY Yang, F He, RL Strack, SY Oh, M Frazer, SR Jaffrey, PK Todd, ...
ACS chemical biology 11 (9), 2456-2465, 2016
Engineering pH-gated transitions for selective and efficient double-strand DNA photocleavage in hypoxic tumors
WY Yang, S Roy, B Phrathep, Z Rengert, R Kenworthy, DAR Zorio, ...
Journal of medicinal chemistry 54 (24), 8501-8516, 2011
2, 5-Pyridinedicarboxylic acid derivatives as non-nucleosidic reverse transcriptase inhibitors of hepatitis B virus
JS Lee, HS Shim, YK Park, SJ Park, JS Shin, WY Yang, HD Lee, WJ Park, ...
Bioorganic & medicinal chemistry letters 12 (19), 2715-2717, 2002
Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates
WY Yang, SA Marrone, N Minors, DAR Zorio, IV Alabugin
Beilstein journal of organic chemistry 7 (1), 813-823, 2011
Intracellular DNA damage by lysine-acetylene conjugates
WY Yang, Q Cao, C Callahan, C Galvis, QX Sang, IV Alabugin
Journal of nucleic acids 2010, 2010
Photochemical Bergman cyclization and related photoreactions of enediynes
IV Alabugin, WY Yang, R Pal
ChemInform 43 (39), no-no, 2012
Benzotriazol-1-yl Alkyl Carbonate, A New Convenient and Inexpensive Coupling Agent to Prepare an Active Ester for the Synthesis of Amide
JS Lee, YS Oh, JK Lim, WY Yang, CW Lee, YH Chung, SJ Yoon
Synthetic communications 29 (14), 2547-2557, 1999
Dipeptide acetylene conjugates and a method for photocleavage of double strand DNA by dipeptide acetylene conjugates
I Alabugin, W Yang, S Roy, K Kaya, Q Sang
US Patent 8,927,728, 2015
Optically active quinoline carboxylic acid derivatives with 7-pyrrolidine substituents causing optical activity and a process for the preparation thereof
SJ Yoon, YH Chung, CW Lee, JS Lee, ND Kim, YH Jin, WJ Song, IH Kim, ...
US Patent 6,753,430, 2004
Enediyne photochemistry
IV Alabugin, WY Yang, R Pal
CRC Handbook of Organic Photochemistry and Photobiology, 549-592, 2012
Specific targeting of RNA expanded repeat sequences
MD Disney, L Guan, W Yang
US Patent 9,586,944, 2017
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