| Discovery of a biomarker and lead small molecules to target r (GGGGCC)-associated defects in c9FTD/ALS Z Su, Y Zhang, TF Gendron, PO Bauer, J Chew, WY Yang, E Fostvedt, ... Neuron 83 (5), 1043-1050, 2014 | 370 | 2014 |
| Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome D Colak, N Zaninovic, MS Cohen, Z Rosenwaks, WY Yang, J Gerhardt, ... Science 343 (6174), 1002-1005, 2014 | 312 | 2014 |
| A Small Molecule That Targets r(CGG)exp and Improves Defects in Fragile X-Associated Tremor Ataxia Syndrome MD Disney, B Liu, WY Yang, C Sellier, T Tran, N Charlet-Berguerand, ... ACS chemical biology 7 (10), 1711-1718, 2012 | 103 | 2012 |
| The hairpin form of r (G4C2) exp in c9ALS/FTD is repeat-associated non-ATG translated and a target for bioactive small molecules ZF Wang, A Ursu, JL Childs-Disney, R Guertler, WY Yang, V Bernat, ... Cell chemical biology 26 (2), 179-190. e12, 2019 | 95 | 2019 |
| C-lysine conjugates: pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy WY Yang, B Breiner, SV Kovalenko, C Ben, M Singh, SN LeGrand, ... Journal of the American Chemical Society 131 (32), 11458-11470, 2009 | 75 | 2009 |
| Hybrids of amino acids and acetylenic DNA-photocleavers: optimising efficiency and selectivity for cancer phototherapy B Breiner, K Kaya, S Roy, WY Yang, IV Alabugin Organic & Biomolecular Chemistry 10 (20), 3974-3987, 2012 | 74 | 2012 |
| Inhibition of non-ATG translational events in cells via covalent small molecules targeting RNA WY Yang, HD Wilson, SP Velagapudi, MD Disney Journal of the American Chemical Society 137 (16), 5336-5345, 2015 | 61 | 2015 |
| Small molecule inhibition of miR-544 biogenesis disrupts adaptive responses to hypoxia by modulating ATM-mTOR signaling CL Haga, SP Velagapudi, JR Strivelli, WY Yang, MD Disney, DG Phinney ACS chemical biology 10 (10), 2267-2276, 2015 | 59 | 2015 |
| Design of a bioactive small molecule that targets r (AUUCU) repeats in spinocerebellar ataxia 10 WY Yang, R Gao, M Southern, PS Sarkar, MD Disney Nature communications 7 (1), 11647, 2016 | 55 | 2016 |
| Small Molecule Recognition and Tools to Study Modulation of r(CGG)exp in Fragile X-Associated Tremor Ataxia Syndrome WY Yang, F He, RL Strack, SY Oh, M Frazer, SR Jaffrey, PK Todd, ... ACS chemical biology 11 (9), 2456-2465, 2016 | 46 | 2016 |
| Engineering pH-gated transitions for selective and efficient double-strand DNA photocleavage in hypoxic tumors WY Yang, S Roy, B Phrathep, Z Rengert, R Kenworthy, DAR Zorio, ... Journal of medicinal chemistry 54 (24), 8501-8516, 2011 | 32 | 2011 |
| 2, 5-Pyridinedicarboxylic acid derivatives as non-nucleosidic reverse transcriptase inhibitors of hepatitis B virus JS Lee, HS Shim, YK Park, SJ Park, JS Shin, WY Yang, HD Lee, WJ Park, ... Bioorganic & medicinal chemistry letters 12 (19), 2715-2717, 2002 | 28 | 2002 |
| Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates WY Yang, SA Marrone, N Minors, DAR Zorio, IV Alabugin Beilstein Journal of Organic Chemistry 7 (1), 813-823, 2011 | 23 | 2011 |
| Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation SN Haify, RAM Buijsen, L Verwegen, LAWFM Severijnen, H de Boer, ... Human Molecular Genetics 30 (17), 1632-1648, 2021 | 10 | 2021 |
| Intracellular DNA damage by lysine-acetylene conjugates WY Yang, Q Cao, C Callahan, C Galvis, QX Sang, IV Alabugin Journal of nucleic acids 2010, 2010 | 9 | 2010 |
| Benzotriazol-1-yl Alkyl Carbonate, A New Convenient and Inexpensive Coupling Agent to Prepare an Active Ester for the Synthesis of Amide JS Lee, YS Oh, JK Lim, WY Yang, CW Lee, YH Chung, SJ Yoon Synthetic communications 29 (14), 2547-2557, 1999 | 8 | 1999 |
| Photochemical Bergman cyclization and related photoreactions of enediynes IV Alabugin, WY Yang, R Pal CRC Handbook of Organic Photochemistry and Photobiology, Third Edition-Two …, 2019 | 7 | 2019 |
| Dipeptide acetylene conjugates and a method for photocleavage of double strand DNA by dipeptide acetylene conjugates I Alabugin, WY Yang, S Roy, K Kaya, QX Sang US Patent 8,927,728, 2015 | 5 | 2015 |
| Optically active quinoline carboxylic acid derivatives with 7-pyrrolidine substituents causing optical activity and a process for the preparation thereof SJ Yoon, YH Chung, CW Lee, JS Lee, ND Kim, YH Jin, WJ Song, IH Kim, ... US Patent 6,753,430, 2004 | 5 | 2004 |
| Enediyne photochemistry IV Alabugin, WY Yang, R Pal CRC Handbook of Organic Photochemistry and Photobiology, 549-592, 2012 | 4 | 2012 |
Matthew D. DisneyThe Scripps Research InstituteVerified email at scripps.edu
