|Discovery of a biomarker and lead small molecules to target r (GGGGCC)-associated defects in c9FTD/ALS|
Z Su, Y Zhang, TF Gendron, PO Bauer, J Chew, WY Yang, E Fostvedt, ...
Neuron 83 (5), 1043-1050, 2014
|Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome|
D Colak, N Zaninovic, MS Cohen, Z Rosenwaks, WY Yang, J Gerhardt, ...
Science 343 (6174), 1002-1005, 2014
|A Small Molecule That Targets r(CGG)exp and Improves Defects in Fragile X-Associated Tremor Ataxia Syndrome|
MD Disney, B Liu, WY Yang, C Sellier, T Tran, N Charlet-Berguerand, ...
ACS chemical biology 7 (10), 1711-1718, 2012
|Hybrids of amino acids and acetylenic DNA-photocleavers: optimising efficiency and selectivity for cancer phototherapy|
B Breiner, K Kaya, S Roy, WY Yang, IV Alabugin
Organic & biomolecular chemistry 10 (20), 3974-3987, 2012
|C-lysine conjugates: pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy|
WY Yang, B Breiner, SV Kovalenko, C Ben, M Singh, SN LeGrand, ...
Journal of the American Chemical Society 131 (32), 11458-11470, 2009
|Small molecule inhibition of miR-544 biogenesis disrupts adaptive responses to hypoxia by modulating ATM-mTOR signaling|
CL Haga, SP Velagapudi, JR Strivelli, WY Yang, MD Disney, DG Phinney
ACS chemical biology 10 (10), 2267-2276, 2015
|Inhibition of non-ATG translational events in cells via covalent small molecules targeting RNA|
WY Yang, HD Wilson, SP Velagapudi, MD Disney
Journal of the American Chemical Society 137 (16), 5336-5345, 2015
|The hairpin form of r (G4C2) exp in c9ALS/FTD is repeat-associated non-ATG translated and a target for bioactive small molecules|
ZF Wang, A Ursu, JL Childs-Disney, R Guertler, WY Yang, V Bernat, ...
Cell chemical biology 26 (2), 179-190. e12, 2019
|Design of a bioactive small molecule that targets r (AUUCU) repeats in spinocerebellar ataxia 10|
WY Yang, R Gao, M Southern, PS Sarkar, MD Disney
Nature communications 7 (1), 1-11, 2016
|Small Molecule Recognition and Tools to Study Modulation of r(CGG)exp in Fragile X-Associated Tremor Ataxia Syndrome|
WY Yang, F He, RL Strack, SY Oh, M Frazer, SR Jaffrey, PK Todd, ...
ACS chemical biology 11 (9), 2456-2465, 2016
|Engineering pH-gated transitions for selective and efficient double-strand DNA photocleavage in hypoxic tumors|
WY Yang, S Roy, B Phrathep, Z Rengert, R Kenworthy, DAR Zorio, ...
Journal of medicinal chemistry 54 (24), 8501-8516, 2011
|2, 5-Pyridinedicarboxylic acid derivatives as non-nucleosidic reverse transcriptase inhibitors of hepatitis B virus|
JS Lee, HS Shim, YK Park, SJ Park, JS Shin, WY Yang, HD Lee, WJ Park, ...
Bioorganic & medicinal chemistry letters 12 (19), 2715-2717, 2002
|Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates|
WY Yang, SA Marrone, N Minors, DAR Zorio, IV Alabugin
Beilstein journal of organic chemistry 7 (1), 813-823, 2011
|Intracellular DNA damage by lysine-acetylene conjugates|
WY Yang, Q Cao, C Callahan, C Galvis, QX Sang, IV Alabugin
Journal of nucleic acids 2010, 2010
|Photochemical Bergman cyclization and related photoreactions of enediynes|
IV Alabugin, WY Yang, R Pal
ChemInform 43 (39), no-no, 2012
|Benzotriazol-1-yl Alkyl Carbonate, A New Convenient and Inexpensive Coupling Agent to Prepare an Active Ester for the Synthesis of Amide|
JS Lee, YS Oh, JK Lim, WY Yang, CW Lee, YH Chung, SJ Yoon
Synthetic communications 29 (14), 2547-2557, 1999
|Dipeptide acetylene conjugates and a method for photocleavage of double strand DNA by dipeptide acetylene conjugates|
I Alabugin, W Yang, S Roy, K Kaya, Q Sang
US Patent 8,927,728, 2015
|Optically active quinoline carboxylic acid derivatives with 7-pyrrolidine substituents causing optical activity and a process for the preparation thereof|
SJ Yoon, YH Chung, CW Lee, JS Lee, ND Kim, YH Jin, WJ Song, IH Kim, ...
US Patent 6,753,430, 2004
IV Alabugin, WY Yang, R Pal
CRC Handbook of Organic Photochemistry and Photobiology, 549-592, 2012
|Specific targeting of RNA expanded repeat sequences|
MD Disney, L Guan, W Yang
US Patent 9,586,944, 2017