| Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing MC Didiot, LM Hall, AH Coles, RA Haraszti, BMDC Godinho, K Chase, ... Molecular Therapy 24 (10), 1836-1847, 2016 | 445 | 2016 |
| RNAi modulation of placental sFLT1 for the treatment of preeclampsia AA Turanov, A Lo, MR Hassler, A Makris, A Ashar-Patel, JF Alterman, ... Nature biotechnology 36 (12), 1164-1173, 2018 | 159 | 2018 |
| A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system JF Alterman, BMDC Godinho, MR Hassler, CM Ferguson, D Echeverria, ... Nature biotechnology 37 (8), 884-894, 2019 | 148 | 2019 |
| Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo MR Hassler, AA Turanov, JF Alterman, RA Haraszti, AH Coles, MF Osborn, ... Nucleic acids research 46 (5), 2185-2196, 2018 | 146 | 2018 |
| Self-assembling Modified β-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington’s Disease BMDC Godinho, JR Ogier, R Darcy, CM O'Driscoll, JF Cryan Molecular Pharmaceutics, 2012 | 132 | 2012 |
| Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways MF Osborn, AH Coles, A Biscans, RA Haraszti, L Roux, S Davis, S Ly, ... Nucleic acids research 47 (3), 1070-1081, 2019 | 110 | 2019 |
| 5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo RA Haraszti, L Roux, AH Coles, AA Turanov, JF Alterman, D Echeverria, ... Nucleic acids research 45 (13), 7581-7592, 2017 | 99 | 2017 |
| Docosahexaenoic acid conjugation enhances distribution and safety of siRNA upon local administration in mouse brain M Nikan, MF Osborn, AH Coles, BMDC Godinho, LM Hall, RA Haraszti, ... Molecular Therapy-Nucleic Acids 5, 2016 | 84 | 2016 |
| Click-modified cyclodextrins as nonviral vectors for neuronal siRNA delivery AM O’Mahony, BMDC Godinho, J Ogier, M Devocelle, R Darcy, JF Cryan, ... ACS chemical neuroscience 3 (10), 744-752, 2012 | 83 | 2012 |
| Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin type 2 receptor M Flores-Munoz, BMDC Godinho, A Almalik, SA Nicklin Public Library of Science 7 (9), e45564, 2012 | 80 | 2012 |
| Serum deprivation of mesenchymal stem cells improves exosome activity and alters lipid and protein composition RA Haraszti, R Miller, ML Dubuke, HE Rockwell, AH Coles, E Sapp, ... Iscience 16, 230-241, 2019 | 72 | 2019 |
| Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: in vitro analysis M Gooding, M Malhotra, DJ McCarthy, BMDC Godinho, JF Cryan, R Darcy, ... European Journal of Pharmaceutical Sciences 71, 80-92, 2015 | 69 | 2015 |
| Non-viral nanosystems for gene and small interfering RNA delivery to the central nervous system: formulating the solution AM O’Mahony, BMDC Godinho, JF Cryan, CM O’Driscoll Journal of pharmaceutical sciences 102 (10), 3469-3484, 2013 | 61 | 2013 |
| Delivering a disease-modifying treatment for Huntington's disease BMDC Godinho, M Malhotra, CM O’Driscoll, JF Cryan Drug discovery today 20 (1), 50-64, 2015 | 50 | 2015 |
| PEGylated cyclodextrins as novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability BMDC Godinho, JR Ogier, A Quinlan, R Darcy, BT Griffin, JF Cryan, ... International journal of pharmaceutics 473 (1-2), 105-112, 2014 | 50 | 2014 |
| Pharmacokinetic profiling of conjugated therapeutic oligonucleotides: a high-throughput method based upon serial blood microsampling coupled to peptide nucleic acid … BMDC Godinho, JW Gilbert, RA Haraszti, AH Coles, A Biscans, L Roux, ... nucleic acid therapeutics 27 (6), 323-334, 2017 | 44 | 2017 |
| A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo AH Coles, MF Osborn, JF Alterman, AA Turanov, BMDC Godinho, ... nucleic acid therapeutics 26 (2), 86-92, 2016 | 42 | 2016 |
| Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system BMDC Godinho, DJ McCarthy, C Torres-Fuentes, CJ Beltrán, J McCarthy, ... Biomaterials 35 (1), 489-499, 2014 | 39 | 2014 |
| Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in … M Nikan, MF Osborn, AH Coles, A Biscans, BMDC Godinho, RA Haraszti, ... Bioconjugate chemistry 28 (6), 1758-1766, 2017 | 36 | 2017 |
| Transvascular delivery of hydrophobically modified siRNAs: gene silencing in the rat brain upon disruption of the blood-brain barrier BMDC Godinho, N Henninger, J Bouley, JF Alterman, RA Haraszti, ... Molecular Therapy 26 (11), 2580-2591, 2018 | 35 | 2018 |
