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Elizabeth CM de Lange
Elizabeth CM de Lange
Professor at LACDR, Leiden University
Geverifieerd e-mailadres voor lacdr.leidenuniv.nl
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Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
J Wijnholds, ECM de Lange, GL Scheffer, DJ van den Berg, CAAM Mol, ...
The Journal of clinical investigation 105 (3), 279-285, 2000
4602000
Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice
OC Meijer, ECM De Lange, DD Breimer, AG De Boer, JO Workel, ...
Endocrinology 139 (4), 1789-1793, 1998
4581998
Age-associated physiological and pathological changes at the blood–brain barrier: A review
F Erdő, L Denes, E de Lange
Journal of Cerebral Blood Flow & Metabolism 37 (1), 4-24, 2017
4162017
Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain
AM Karssen, OC Meijer, ICJ Van Der Sandt, PJ Lucassen, ECM De Lange, ...
Endocrinology 142 (6), 2686-2694, 2001
3392001
Methodological issues in microdialysis sampling for pharmacokinetic studies
ECM de Lange, AG De Boer, DD Breimer
Advanced drug delivery reviews 45 (2-3), 125-148, 2000
3252000
Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research
M Danhof, ECM De Lange, OE Della Pasqua, BA Ploeger, RA Voskuyl
Trends in pharmacological sciences 29 (4), 186-191, 2008
3232008
Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis
M Danhof, J de Jongh, ECM De Lange, O Della Pasqua, BA Ploeger, ...
Annu. Rev. Pharmacol. Toxicol. 47, 357-400, 2007
2952007
Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood–brain barrier
ECM de Lange, M Danhof, AG de Boer, DD Breimer
Brain research reviews 25 (1), 27-49, 1997
2731997
Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and …
ECM de Lange, M Danhof
Clinical pharmacokinetics 41, 691-703, 2002
2672002
The role of P‐glycoprotein in blood‐brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (−/−) and mdr1a (+/+) mice
R Xie, M Hammarlund‐Udenaes, AG De Boer, ECM De Lange
British journal of pharmacology 128 (3), 563-568, 1999
2431999
Potential role of ABC transporters as a detoxification system at the blood–CSF barrier
ECM de Lange
Advanced drug delivery reviews 56 (12), 1793-1809, 2004
2212004
Drug Equilibration Across the Blood—Brain Barrier-Pharmacokinetic Considerations Based on the Microdialysis Method
M Hammarlund-Udenaes, LK Paalzow, ECM de Lange
Pharmaceutical research 14, 128-134, 1997
1981997
Kinetics for Drug Discovery: an industry-driven effort to target drug residence time
DA Schuetz, WEA de Witte, YC Wong, B Knasmueller, L Richter, DB Kokh, ...
Drug Discovery Today 22 (6), 896-911, 2017
1922017
Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood–brain barrier in rats
J Rip, L Chen, R Hartman, A van den Heuvel, A Reijerkerk, J van Kregten, ...
Journal of drug targeting 22 (5), 460-467, 2014
1812014
Imaging techniques in Alzheimer’s disease: a review of applications in early diagnosis and longitudinal monitoring
WM van Oostveen, ECM de Lange
International journal of molecular sciences 22 (4), 2110, 2021
1502021
P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice
GJ Sills, P Kwan, E Butler, ECM de Lange, DJ van den Berg, MJ Brodie
Epilepsy & Behavior 3 (5), 427-432, 2002
1432002
Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats
J Westerhout, B Ploeger, J Smeets, M Danhof, ECM de Lange
The AAPS journal 14, 543-553, 2012
1372012
Critical factors of intracerebral microdialysis as a technique to determined the pharmacokinetics of drugs in rat brain
ECM de Lange, M Danhof, AG de Boer, DD Breimer
Brain research 666 (1), 1-8, 1994
1371994
The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects
ECM de Lange
Fluids and Barriers of the CNS 10, 1-16, 2013
1232013
The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone
AM Karssen, OC Meijer, ICJ Van Der Sandt, AG De Boer, ECM De Lange, ...
Journal of endocrinology 175 (1), 251-260, 2002
1222002
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Artikelen 1–20