Elizabeth CM de Lange
Elizabeth CM de Lange
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Geverifieerd e-mailadres voor lacdr.leidenuniv.nl
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Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
J Wijnholds, ECM de Lange, GL Scheffer, DJ van den Berg, CAAM Mol, ...
The Journal of clinical investigation 105 (3), 279-285, 2000
4142000
Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice
OC Meijer, ECM De Lange, DD Breimer, AG De Boer, JO Workel, ...
Endocrinology 139 (4), 1789-1793, 1998
4081998
Methodological issues in microdialysis sampling for pharmacokinetic studies
ECM de Lange, AG De Boer, DD Breimer
Advanced drug delivery reviews 45 (2-3), 125-148, 2000
3082000
Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain
AM Karssen, OC Meijer, ICJ Van Der Sandt, PJ Lucassen, ECM De Lange, ...
Endocrinology 142 (6), 2686-2694, 2001
3072001
Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research
M Danhof, ECM de Lange, OE Della Pasqua, BA Ploeger, RA Voskuyl
Trends in pharmacological sciences 29 (4), 186-191, 2008
2922008
Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis
M Danhof, J de Jongh, ECM De Lange, O Della Pasqua, BA Ploeger, ...
Annu. Rev. Pharmacol. Toxicol. 47, 357-400, 2007
2742007
Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood–brain barrier
ECM de Lange, M Danhof, AG de Boer, DD Breimer
Brain research reviews 25 (1), 27-49, 1997
2601997
Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting
ECM de Lange, M Danhof
Clinical pharmacokinetics 41 (10), 691-703, 2002
2402002
Age-associated physiological and pathological changes at the blood–brain barrier: a review
F Erdő, L Denes, E de Lange
Journal of Cerebral Blood Flow & Metabolism 37 (1), 4-24, 2017
2372017
The role of P‐glycoprotein in blood‐brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (−/−) and mdr1a (+/+) mice
R Xie, M Hammarlund‐Udenaes, AG De Boer, ECM De Lange
British journal of pharmacology 128 (3), 563-568, 1999
2261999
Potential role of ABC transporters as a detoxification system at the blood–CSF barrier
ECM de Lange
Advanced drug delivery reviews 56 (12), 1793-1809, 2004
2052004
Drug Equilibration Across the Blood—Brain Barrier-Pharmacokinetic Considerations Based on the Microdialysis Method
M Hammarlund-Udenaes, LK Paalzow, ECM de Lange
Pharmaceutical research 14 (2), 128-134, 1997
1871997
Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood–brain barrier in rats
J Rip, L Chen, R Hartman, A van den Heuvel, A Reijerkerk, J van Kregten, ...
Journal of drug targeting 22 (5), 460-467, 2014
1312014
Critical factors of intracerebral microdialysis as a technique to determined the pharmacokinetics of drugs in rat brain
ECM de Lange, M Danhof, AG de Boer, DD Breimer
Brain research 666 (1), 1-8, 1994
1301994
P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice
GJ Sills, P Kwan, E Butler, ECM de Lange, DJ van den Berg, MJ Brodie
Epilepsy & Behavior 3 (5), 427-432, 2002
1292002
Kinetics for Drug Discovery: an industry-driven effort to target drug residence time
DA Schuetz, WEA de Witte, YC Wong, B Knasmueller, L Richter, DB Kokh, ...
Drug Discovery Today 22 (6), 896-911, 2017
1202017
The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone
AM Karssen, OC Meijer, ICJ Van der Sandt, AG De Boer, ECM De Lange, ...
Journal of endocrinology 175 (1), 251-260, 2002
1132002
In vitro and in vivo investigations on fluoroquinolones; effects of the P-glycoprotein efflux transporter on brain distribution of sparfloxacin
ECM de Lange, S Marchand, DJ van den Berg, ICJ van der Sandt, ...
European journal of pharmaceutical sciences 12 (2), 85-93, 2000
1122000
Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats
J Westerhout, B Ploeger, J Smeets, M Danhof, ECM de Lange
The AAPS journal 14 (3), 543-553, 2012
1102012
Microdialysis for pharmacokinetic analysis of drug transport to the brain
ECM de Lange, BAG de Boer, DD Breimer
Advanced drug delivery reviews 36 (2-3), 211-227, 1999
1091999
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