| Search-and-replace genome editing without double-strand breaks or donor DNA AV Anzalone, PB Randolph, JR Davis, AA Sousa, LW Koblan, JM Levy, ... Nature 576 (7785), 149-157, 2019 | 3410 | 2019 |
| Enhanced proofreading governs CRISPR–Cas9 targeting accuracy JS Chen, YS Dagdas, BP Kleinstiver, MM Welch, AA Sousa, ... Nature 550 (7676), 407-410, 2017 | 1121 | 2017 |
| Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing BP Kleinstiver, AA Sousa, RT Walton, YE Tak, JY Hsu, K Clement, ... Nature biotechnology 37 (3), 276-282, 2019 | 529 | 2019 |
| Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications AE Friedland, R Baral, P Singhal, K Loveluck, S Shen, M Sanchez, ... Genome biology 16, 1-10, 2015 | 340 | 2015 |
| High levels of AAV vector integration into CRISPR-induced DNA breaks KS Hanlon, BP Kleinstiver, SP Garcia, MP Zaborowski, A Volak, SE Spirig, ... Nature communications 10 (1), 4439, 2019 | 314 | 2019 |
| Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs J Listgarten, M Weinstein, BP Kleinstiver, AA Sousa, JK Joung, J Crawford, ... Nature biomedical engineering 2 (1), 38-47, 2018 | 271 | 2018 |
| Discovery of widespread type I and type V CRISPR-Cas inhibitors ND Marino, JY Zhang, AL Borges, AA Sousa, LM Leon, BJ Rauch, ... Science 362 (6411), 240-242, 2018 | 234 | 2018 |
| Designing and executing prime editing experiments in mammalian cells JL Doman, AA Sousa, PB Randolph, PJ Chen, DR Liu Nature protocols 17 (11), 2431-2468, 2022 | 46 | 2022 |
| Adenine transversion editors enable precise, efficient A• T-to-C• G base editing in mammalian cells and embryos L Chen, M Hong, C Luan, H Gao, G Ru, X Guo, D Zhang, S Zhang, C Li, ... Nature biotechnology 42 (4), 638-650, 2024 | 40 | 2024 |
| Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice KA Everette, GA Newby, RM Levine, K Mayberry, Y Jang, T Mayuranathan, ... Nature biomedical engineering 7 (5), 616-628, 2023 | 40 | 2023 |
| Variants of Cpf1 (Cas12a) with altered PAM specificity JK Joung, B Kleinstiver, A Sousa US Patent 11,591,589, 2023 | 38 | 2023 |
| Enhanced Proofreading Governs CRISPR-Cas9 Targeting Accuracy JS Chen, YS Dagdas, BP Kleinstiver, MM Welch, AA Sousa, ... Biophysical Journal 114 (3), 194a, 2018 | 9 | 2018 |
| Variants of cpf1 (cas12a) with altered pam specificity JK Joung, B KLEINSTIVER, A SOUSA | 4 | 2018 |
| Publisher Correction: Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing BP Kleinstiver, AA Sousa, RT Walton, YE Tak, JY Hsu, K Clement, ... Nature biotechnology 38 (7), 901, 2020 | 3 | 2020 |
| Development of a Prime Editing Strategy to Treat Mutations in the Crumbs Homologue 1 (CRB1) Gene BL Costa, AA Sousa, YT Tsai, Y Li, IH Maumenee, DR Liu, SH Tsang, ... Investigative Ophthalmology & Visual Science 64 (8), 3862-3862, 2023 | | 2023 |
| Development of a Prime Editing Strategy to Treat Mutations in the Crumbs Homologue 1 (CRB1) Gene BL Da Costa, AA Sousa, YT Tsai, Y Li, IH Maumenee, DR Liu, SH Tsang, ... MOLECULAR THERAPY 30 (4), 260-261, 2022 | | 2022 |
| Variants of CPF1 (CAS12a) With Altered PAM Specificity JK Joung, B Kleinstiver, A Sousa US Patent App. 17/244,738, 2021 | | 2021 |
| Enhancing Genome Editing with Engineered CRISPR Nucleases RT Walton, AA Sousa, MM Welch, YE Tak, JY Hsu, K Clement, JE Horng, ... MOLECULAR THERAPY 27 (4), 104-105, 2019 | | 2019 |
| AAV-Vector Integration into CRISPR-Induced Double-Stranded Breaks B Gyorgy, BP Kleinstiver, SP Garcia, M Zaborowski, AA Sousa, SQ Tsai, ... Molecular Therapy 26 (5), 432-433, 2018 | | 2018 |
| Activity and Specificity of Engineered CRISPR-Cpf1 Nucleases in Human Cells BP Kleinstiver, AA Sousa, MM Welch, MS Prew, SQ Tsai, NT Nguyen, ... MOLECULAR THERAPY 25 (5), 9-9, 2017 | | 2017 |
