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| Cellular senescence: defining a path forward V Gorgoulis, PD Adams, A Alimonti, DC Bennett, O Bischof, C Bishop, ... Cell 179 (4), 813-827, 2019 | 1797 | 2019 |
| Senolytics improve physical function and increase lifespan in old age M Xu, T Pirtskhalava, JN Farr, BM Weigand, AK Palmer, MM Weivoda, ... Nature medicine 24 (8), 1246-1256, 2018 | 1654 | 2018 |
| Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors YI Zhu, T Tchkonia, H Fuhrmann‐Stroissnigg, HM Dai, YY Ling, MB Stout, ... Aging cell 15 (3), 428-435, 2016 | 921 | 2016 |
| A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis LJ Niedernhofer, GA Garinis, A Raams, AS Lalai, AR Robinson, ... Nature 444 (7122), 1038-1043, 2006 | 743 | 2006 |
| Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells LJ Niedernhofer, JS Daniels, CA Rouzer, RE Greene, LJ Marnett Journal of Biological Chemistry 278 (33), 31426-31433, 2003 | 709 | 2003 |
| Fisetin is a senotherapeutic that extends health and lifespan MJ Yousefzadeh, YI Zhu, SJ McGowan, L Angelini, ... EBioMedicine 36, 18-28, 2018 | 668 | 2018 |
| The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks LJ Niedernhofer, H Odijk, M Budzowska, E Van Drunen, A Maas, AF Theil, ... Molecular and cellular biology, 2004 | 613 | 2004 |
| Identification of HSP90 inhibitors as a novel class of senolytics H Fuhrmann-Stroissnigg, YY Ling, J Zhao, SJ McGowan, YI Zhu, ... Nature communications 8 (1), 422, 2017 | 583 | 2017 |
| New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463 Y Zhu, EJ Doornebal, T Pirtskhalava, N Giorgadze, M Wentworth, ... Aging (Albany NY) 9 (3), 955, 2017 | 576 | 2017 |
| The clinical potential of senolytic drugs JL Kirkland, T Tchkonia, Y Zhu, LJ Niedernhofer, PD Robbins Journal of the American Geriatrics Society 65 (10), 2297-2301, 2017 | 530 | 2017 |
| ERCC1/XPF removes the 3′ overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes XD Zhu, L Niedernhofer, B Kuster, M Mann, JHJ Hoeijmakers, T De Lange Molecular cell 12 (6), 1489-1498, 2003 | 506 | 2003 |
| NF-κB inhibition delays DNA damage–induced senescence and aging in mice JS Tilstra, AR Robinson, J Wang, SQ Gregg, CL Clauson, DP Reay, ... The Journal of clinical investigation 122 (7), 2601-2612, 2012 | 491 | 2012 |
| An aged immune system drives senescence and ageing of solid organs MJ Yousefzadeh, RR Flores, YI Zhu, ZC Schmiechen, RW Brooks, ... Nature 594 (7861), 100-105, 2021 | 437 | 2021 |
| NF-κB in aging and disease JS Tilstra, CL Clauson, LJ Niedernhofer, PD Robbins Aging and disease 2 (6), 449, 2011 | 423 | 2011 |
| ERCC1-XPF endonuclease facilitates DNA double-strand break repair A Ahmad, AR Robinson, A Duensing, E Van Drunen, HB Beverloo, ... Molecular and cellular biology 28 (16), 5082-5092, 2008 | 392 | 2008 |
| Fanconi anemia (cross) linked to DNA repair LJ Niedernhofer, AS Lalai, JHJ Hoeijmakers Cell 123 (7), 1191-1198, 2005 | 362 | 2005 |
| Tet-mediated formation of 5-hydroxymethylcytosine in RNA L Fu, CR Guerrero, N Zhong, NJ Amato, Y Liu, S Liu, Q Cai, D Ji, SG Jin, ... Journal of the American Chemical Society 136 (33), 11582-11585, 2014 | 337 | 2014 |
| Advances in understanding the complex mechanisms of DNA interstrand cross-link repair C Clauson, OD Schärer, L Niedernhofer Cold Spring Harbor perspectives in biology 5 (10), a012732, 2013 | 307 | 2013 |
| Impaired genome maintenance suppresses the growth hormone–insulin-like growth factor 1 axis in mice with Cockayne syndrome I Van Der Pluijm, GA Garinis, RMC Brandt, TGMF Gorgels, SW Wijnhoven, ... PLoS biology 5 (1), e2, 2007 | 268 | 2007 |
