Brian Dymock
Brian Dymock
Director of Chemistry
Verified email at uniquest.com.au
Title
Cited by
Cited by
Year
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
SA Eccles, A Massey, FI Raynaud, SY Sharp, G Box, M Valenti, ...
Cancer research 68 (8), 2850-2860, 2008
4482008
4, 5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer
PA Brough, W Aherne, X Barril, J Borgognoni, K Boxall, JE Cansfield, ...
Journal of medicinal chemistry 51 (2), 196-218, 2008
4132008
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms
L Wright, X Barril, B Dymock, L Sheridan, A Surgenor, M Beswick, ...
Chemistry & biology 11 (6), 775-785, 2004
2512004
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design
BW Dymock, X Barril, PA Brough, JE Cansfield, A Massey, E McDonald, ...
Journal of medicinal chemistry 48 (13), 4212-4215, 2005
2422005
SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies
S Hart, KC Goh, V Novotny-Diermayr, CY Hu, H Hentze, YC Tan, B Madan, ...
Leukemia 25 (11), 1751-1759, 2011
1592011
Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular …
PA Brough, X Barril, J Borgognoni, P Chene, NGM Davies, B Davis, ...
Journal of medicinal chemistry 52 (15), 4794-4809, 2009
1522009
Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets
N Baurin, F Aboul-Ela, X Barril, B Davis, M Drysdale, B Dymock, H Finch, ...
Journal of chemical information and computer sciences 44 (6), 2157-2166, 2004
1452004
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues
SY Sharp, C Prodromou, K Boxall, MV Powers, JL Holmes, G Box, ...
Molecular cancer therapeutics 6 (4), 1198-1211, 2007
1392007
Novel approaches to the treatment of hepatitis C virus infection
BW Dymock, PS Jones, FX Wilson
Antiviral Chemistry and Chemotherapy 11 (2), 79-86, 2000
1262000
Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14, 19-dioxa-5, 7, 26-triaza-tetracyclo [19.3. 1.1 (2, 6). 1 (8, 12)] heptacosa-1 (25), 2 (26), 3, 5, 8, 10, 12 (27 …
AD William, ACH Lee, S Blanchard, A Poulsen, EL Teo, H Nagaraj, E Tan, ...
Journal of medicinal chemistry 54 (13), 4638-4658, 2011
1242011
4-Amino derivatives of the Hsp90 inhibitor CCT018159
X Barril, MC Beswick, A Collier, MJ Drysdale, BW Dymock, A Fink, K Grant, ...
Bioorganic & medicinal chemistry letters 16 (9), 2543-2548, 2006
1042006
Emerging therapies for hepatitis C virus infection
BW Dymock
Emerging Drugs 6 (1), 13-42, 2001
1042001
Anti-HCV nucleoside derivatives
R Devos, B Dymock, C Hobbs, WR Jiang, J Martin, J Merrett, I Najera, ...
US Patent App. 09/923,620, 2003
1002003
3-(5-Chloro-2, 4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone
PA Brough, X Barril, M Beswick, BW Dymock, MJ Drysdale, L Wright, ...
Bioorganic & medicinal chemistry letters 15 (23), 5197-5201, 2005
922005
Anti-HCV nucleoside derivatives
R Devos, B Dymock, C Hobbs, WR Jiang, J Martin, J Merrett, I Najera, ...
US Patent App. 10/678,804, 2004
842004
A fluorescence polarization assay for inhibitors of Hsp90
R Howes, X Barril, BW Dymock, K Grant, CJ Northfield, AGS Robertson, ...
Analytical biochemistry 350 (2), 202-213, 2006
832006
Inhibitors of HSP90 and other chaperones for the treatment of cancer
BW Dymock, MJ Drysdale, E McDonald, P Workman
Expert Opinion on Therapeutic Patents 14 (6), 837-847, 2004
822004
TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties
KC Goh, V Novotny-Diermayr, S Hart, LC Ong, YK Loh, A Cheong, ...
Leukemia 26 (2), 236-243, 2012
782012
Adenine derived inhibitors of the molecular chaperone HSP90—SAR explained through multiple X-ray structures
B Dymock, X Barril, M Beswick, A Collier, N Davies, M Drysdale, A Fink, ...
Bioorganic & medicinal chemistry letters 14 (2), 325-328, 2004
752004
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity
SP East, CB White, O Barker, S Barker, J Bennett, D Brown, EA Boyd, ...
Bioorganic & medicinal chemistry letters 19 (3), 894-899, 2009
732009
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