| Inducible apoptosis as a safety switch for adoptive cell therapy A Di Stasi, SK Tey, G Dotti, Y Fujita, A Kennedy-Nasser, C Martinez, ... New England Journal of Medicine 365 (18), 1673-1683, 2011 | 1585 | 2011 |
| Controlling signal transduction with synthetic ligands DM Spencer, TJ Wandless, SL Schreiber, GR Crabtree Science 262 (5136), 1019-1024, 1993 | 1144 | 1993 |
| An inducible caspase 9 safety switch for T-cell therapy KC Straathof, MA Pule, P Yotnda, G Dotti, EF Vanin, MK Brenner, ... Blood 105 (11), 4247-4254, 2005 | 799 | 2005 |
| Caspase-10 is an initiator caspase in death receptor signaling J Wang, HJ Chun, W Wong, DM Spencer, MJ Lenardo Proceedings of the National Academy of Sciences 98 (24), 13884-13888, 2001 | 578 | 2001 |
| WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation Y Hu, L Ding, DM Spencer, G Núñez Journal of Biological Chemistry 273 (50), 33489-33494, 1998 | 363 | 1998 |
| Dimeric ligands define a role for transcriptional activation domains in reinitiation SN Ho, SR Biggar, DM Spencer, SL Schreiber, GR Crabtree Nature 382 (6594), 822-826, 1996 | 357 | 1996 |
| Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition VD Acevedo, RD Gangula, KW Freeman, R Li, Y Zhang, F Wang, ... Cancer cell 12 (6), 559-571, 2007 | 349 | 2007 |
| Regulated transcription of targeted genes and other biological events GR Crabtree, SL Schreiber, DM Spencer, TJ Wandless, P Belshaw US Patent 5,869,337, 1999 | 282* | 1999 |
| Synthetic activation of caspases: artificial death switches RA MacCorkle, KW Freeman, DM Spencer Proceedings of the National Academy of Sciences 95 (7), 3655-3660, 1998 | 276 | 1998 |
| Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma LE Budde, C Berger, Y Lin, J Wang, X Lin, SE Frayo, SA Brouns, ... PloS one 8 (12), e82742, 2013 | 245 | 2013 |
| Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation X Zhou, G Dotti, RA Krance, CA Martinez, S Naik, RT Kamble, AG Durett, ... Blood, The Journal of the American Society of Hematology 125 (26), 4103-4113, 2015 | 233 | 2015 |
| Pleiotropic biological activities of alternatively spliced TMPRSS2/ERG fusion gene transcripts J Wang, Y Cai, W Yu, C Ren, DM Spencer, M Ittmann Cancer research 68 (20), 8516-8524, 2008 | 227 | 2008 |
| Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization DM Spencer, PJ Belshaw, L Chen, SN Ho, F Randazzo, GR Crabtree, ... Current Biology 6 (7), 839-847, 1996 | 207 | 1996 |
| Signal transduction in T lymphocytes using a conditional allele of Sos. LJ Holsinger, DM Spencer, DJ Austin, SL Schreiber, GR Crabtree Proceedings of the National Academy of Sciences 92 (21), 9810-9814, 1995 | 191 | 1995 |
| Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene X Zhou, A Di Stasi, SK Tey, RA Krance, C Martinez, KS Leung, AG Durett, ... Blood, The Journal of the American Society of Hematology 123 (25), 3895-3905, 2014 | 186 | 2014 |
| Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies G Dotti, DM Spencer, CM Rooney, MK Brenner US Patent App. 13/458,085, 2013 | 184 | 2013 |
| T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies DR Shaffer, B Savoldo, Z Yi, KKH Chow, S Kakarla, DM Spencer, G Dotti, ... Blood, The Journal of the American Society of Hematology 117 (16), 4304-4314, 2011 | 183 | 2011 |
| Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland BE Welm, KW Freeman, M Chen, A Contreras, DM Spencer, JM Rosen The Journal of cell biology 157 (4), 703-714, 2002 | 182 | 2002 |
| Paths of FGFR-driven tumorigenesis VD Acevedo, M Ittmann, DM Spencer Cell Cycle 8 (4), 580-588, 2009 | 177 | 2009 |
| Regulated apoptosis GR Crabtree, SL Schreiber, DM Spencer, TJ Wandless, P Belshaw US Patent 5,834,266, 1998 | 159 | 1998 |
