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Denise Kirschner
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A methodology for performing global uncertainty and sensitivity analysis in systems biology
S Marino, IB Hogue, CJ Ray, DE Kirschner
Journal of theoretical biology 254 (1), 178-196, 2008
25542008
Dynamics of HIV infection of CD4+ T cells
AS Perelson, DE Kirschner, R De Boer
Mathematical biosciences 114 (1), 81-125, 1993
11901993
Modeling immunotherapy of the tumor–immune interaction
D Kirschner, JC Panetta
Journal of mathematical biology 37, 235-252, 1998
10441998
Optimal control of the chemotherapy of HIV
D Kirschner, S Lenhart, S Serbin
Journal of mathematical biology 35, 775-792, 1997
6441997
Mathematical approaches for emerging and reemerging infectious diseases: models, methods, and theory
C Castillo-Chavez, S Blower, P van den Driessche, D Kirschner, ...
Springer Science & Business Media, 2002
4362002
Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model
JL Segovia-Juarez, S Ganguli, D Kirschner
Journal of theoretical biology 231 (3), 357-376, 2004
3782004
Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms
JT Mattila, OO Ojo, D Kepka-Lenhart, S Marino, JH Kim, SY Eum, LE Via, ...
The Journal of Immunology 191 (2), 773-784, 2013
3632013
Variability in tuberculosis granuloma T cell responses exists, but a balance of pro-and anti-inflammatory cytokines is associated with sterilization
HP Gideon, JY Phuah, AJ Myers, BD Bryson, MA Rodgers, MT Coleman, ...
PLoS pathogens 11 (1), e1004603, 2015
3152015
Using mathematics to understand HIV immune dynamics
D Kirschner
Notices of the AMS 43 (2), 191-202, 1996
3051996
A model to predict cell-mediated immune regulatory mechanisms during human infection with Mycobacterium tuberculosis
JE Wigginton, D Kirschner
The Journal of Immunology 166 (3), 1951-1967, 2001
2982001
The equilibria that allow bacterial persistence in human hosts
MJ Blaser, D Kirschner
Nature 449 (7164), 843-849, 2007
2922007
A mathematical model of tumor-immune evasion and siRNA treatment
JC Arciero, TL Jackson, DE Kirschner
Discrete and Continuous Dynamical Systems Series B 4 (1), 39-58, 2004
2482004
A model for treatment strategy in the chemotherapy of AIDS
D Kirschner, GF Webb
Bulletin of Mathematical Biology 58, 367-390, 1996
2321996
The human immune response to Mycobacterium tuberculosis in lung and lymph node
S Marino, DE Kirschner
Journal of theoretical biology 227 (4), 463-486, 2004
2172004
Dynamic balance of pro‐and anti‐inflammatory signals controls disease and limits pathology
JM Cicchese, S Evans, C Hult, LR Joslyn, T Wessler, JA Millar, S Marino, ...
Immunological reviews 285 (1), 147-167, 2018
2132018
Tumor necrosis factor blockade in chronic murine tuberculosis enhances granulomatous inflammation and disorganizes granulomas in the lungs
SD Chakravarty, G Zhu, MC Tsai, VP Mohan, S Marino, DE Kirschner, ...
Infection and immunity 76 (3), 916-926, 2008
1972008
Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection
S Marino, NA Cilfone, JT Mattila, JJ Linderman, JAL Flynn, DE Kirschner
Infection and immunity 83 (1), 324-338, 2015
1952015
Multiscale computational modeling reveals a critical role for TNF-α receptor 1 dynamics in tuberculosis granuloma formation
M Fallahi-Sichani, M El-Kebir, S Marino, DE Kirschner, JJ Linderman
The Journal of Immunology 186 (6), 3472-3483, 2011
1942011
Dendritic cell trafficking and antigen presentation in the human immune response to Mycobacterium tuberculosis
S Marino, S Pawar, CL Fuller, TA Reinhart, JAL Flynn, DE Kirschner
The Journal of Immunology 173 (1), 494-506, 2004
1932004
Contribution of CD8+ T cells to control of Mycobacterium tuberculosis infection
D Sud, C Bigbee, JAL Flynn, DE Kirschner
The Journal of Immunology 176 (7), 4296-4314, 2006
1862006
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Articles 1–20