| Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance A Wohlkonig, PF Chan, AP Fosberry, P Homes, J Huang, M Kranz, ... Nature structural & molecular biology 17 (9), 1152-1153, 2010 | 334 | 2010 |
| Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition S Wyllie, S Brand, M Thomas, M De Rycker, C Chung, I Pena, ... Proceedings of the National Academy of Sciences 116 (19), 9318-9323, 2019 | 125 | 2019 |
| Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis S Wyllie, M Thomas, S Patterson, S Crouch, M De Rycker, R Lowe, ... Nature 560 (7717), 192-197, 2018 | 124 | 2018 |
| Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade M De Rycker, J Thomas, J Riley, SJ Brough, TJ Miles, DW Gray PLoS neglected tropical diseases 10 (4), e0004584, 2016 | 71 | 2016 |
| Synthesis of highly-functionalised pyridines via hetero-Diels–Alder methodology: reaction of 3-siloxy-1-aza-1, 3-butadienes with electron deficient acetylenes MD Fletcher, TE Hurst, TJ Miles, CJ Moody Tetrahedron 62 (23), 5454-5463, 2006 | 69 | 2006 |
| Novel hydroxyl tricyclics (eg, GSK966587) as potent inhibitors of bacterial type IIA topoisomerases TJ Miles, AJ Hennessy, B Bax, G Brooks, BS Brown, P Brown, N Cailleau, ... Bioorganic & medicinal chemistry letters 23 (19), 5437-5441, 2013 | 65 | 2013 |
| Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases TJ Miles, C Barfoot, G Brooks, P Brown, D Chen, S Dabbs, DT Davies, ... Bioorganic & medicinal chemistry letters 21 (24), 7483-7488, 2011 | 54 | 2011 |
| Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases TJ Miles, JM Axten, C Barfoot, G Brooks, P Brown, D Chen, S Dabbs, ... Bioorganic & medicinal chemistry letters 21 (24), 7489-7495, 2011 | 53 | 2011 |
| Novel tricyclics (eg, GSK945237) as potent inhibitors of bacterial type IIA topoisomerases TJ Miles, AJ Hennessy, B Bax, G Brooks, BS Brown, P Brown, N Cailleau, ... Bioorganic & medicinal chemistry letters 26 (10), 2464-2469, 2016 | 48 | 2016 |
| H.; Matthews, IR; Wilson, FX; Witherington DM Hodgson, CR Maxwell, TJ Miles, E Paruch, MA Stent Angew. Chem. Int. Ed 41, 4313, 2002 | 45 | 2002 |
| Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi S Brand, EJ Ko, E Viayna, S Thompson, D Spinks, M Thomas, L Sandberg, ... Journal of medicinal chemistry 60 (17), 7284-7299, 2017 | 44 | 2017 |
| Identification of GSK3186899/DDD853651 as a preclinical development candidate for the treatment of visceral leishmaniasis MG Thomas, M De Rycker, M Ajakane, S Albrecht, AI Álvarez-Pedraglio, ... Journal of Medicinal Chemistry 62 (3), 1180-1202, 2018 | 39 | 2018 |
| Organolithium-induced alkylative ring opening of aziridines: synthesis of unsaturated amino alcohols and ethers DM Hodgson, B Štefane, TJ Miles, J Witherington The Journal of Organic Chemistry 71 (22), 8510-8515, 2006 | 39 | 2006 |
| Asymmetric synthesis of the fully elaborated pyrrolidinone core of Oxazolomycin A TJ Donohoe, TJC O’Riordan, M Peifer, CR Jones, TJ Miles Organic letters 14 (21), 5460-5463, 2012 | 36 | 2012 |
| Organolithium-induced enantioselective alkylative double ring-opening of epoxides: synthesis of enantioenriched unsaturated amino alcohols DM Hodgson, CR Maxwell, TJ Miles, E Paruch, IR Matthews, ... Tetrahedron 60 (16), 3611-3624, 2004 | 29 | 2004 |
| The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani RJ Wall, S Carvalho, R Milne, JA Bueren-Calabuig, S Moniz, ... ACS infectious diseases 6 (3), 515-528, 2020 | 25 | 2020 |
| Organolithium-induced synthesis of acyclic unsaturated amino alcohols from epoxides of dihydropyrroles and tetrahydropyridines DM Hodgson, TJ Miles, J Witherington Tetrahedron 59 (49), 9729-9742, 2003 | 25 | 2003 |
| Scaffold-hopping strategy on a series of proteasome inhibitors led to a preclinical candidate for the treatment of visceral leishmaniasis M Thomas, S Brand, M De Rycker, F Zuccotto, I Lukac, PG Dodd, EJ Ko, ... Journal of Medicinal Chemistry 64 (9), 5905-5930, 2021 | 24 | 2021 |
| Flexible palladium-catalysed amidation reactions for the synthesis of complex aryl amides C Barfoot, G Brooks, P Brown, S Dabbs, DT Davies, I Giordano, ... Tetrahedron Letters 51 (20), 2685-2689, 2010 | 20 | 2010 |
| The design of efficient and selective routes to pyridyl analogues of 3-oxo-3, 4-dihydro-2H-1, 4-(benzothiazine or benzoxazine)-6-carbaldehydes G Brooks, S Dabbs, DT Davies, AJ Hennessy, GE Jones, RE Markwell, ... Tetrahedron Letters 51 (38), 5035-5037, 2010 | 19 | 2010 |
Neil D PearsonGlaxoSmithKlineVerified email at gsk.com
