| Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD AF Baas, J Boudeau, GP Sapkota, L Smit, R Medema, NA Morrice, ... The EMBO journal 22 (12), 3062-3072, 2003 | 464 | 2003 |
| Signaling through CD44 is mediated by tyrosine kinases: association with p56lck in T lymphocytes TEI Taher, L Smit, AW Griffioen, EJM Schilder-Tol, J Borst, ST Pals Journal of Biological Chemistry 271 (5), 2863-2867, 1996 | 203 | 1996 |
| Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer J Carretero, PP Medina, R Blanco, L Smit, M Tang, G Roncador, ... Oncogene 26 (11), 1616-1625, 2007 | 176 | 2007 |
| LKB1 tumor suppressor protein: PARtaker in cell polarity AF Baas, L Smit, H Clevers Trends in cell biology 14 (6), 312-319, 2004 | 167 | 2004 |
| Wnt activates the Tak1/Nemo-like kinase pathway L Smit, A Baas, J Kuipers, H Korswagen, M van de Wetering, H Clevers Journal of Biological Chemistry 279 (17), 17232-17240, 2004 | 151 | 2004 |
| Sos, Vav, and C3G Participate in B Cell Receptor-induced Signaling Pathways and Differentially Associate with Shc-Grb2, Crk, and Crk-L Adaptors (∗) L Smit, G van der Horst, J Borst Journal of Biological Chemistry 271 (15), 8564-8569, 1996 | 132 | 1996 |
| B cell antigen receptor stimulation induces formation of a Shc-Grb2 complex containing multiple tyrosine-phosphorylated proteins. L Smit, AM de Vries-Smits, JL Bos, J Borst Journal of Biological Chemistry 269 (32), 20209-20212, 1994 | 109 | 1994 |
| Attenuation of microRNA-126 Expression That Drives CD34+ 38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor EradicationKnockdown of microRNA-126 Eradicates … DC de Leeuw, F Denkers, MC Olthof, AP Rutten, W Pouwels, ... Cancer research 74 (7), 2094-2105, 2014 | 107 | 2014 |
| How can we build and maintain the resilience of our health care professionals during COVID-19? Recommendations based on a scoping review A Rieckert, E Schuit, N Bleijenberg, D Ten Cate, W De Lange, ... BMJ open 11 (1), e043718, 2021 | 95 | 2021 |
| The Cbl family of signal transduction molecules L Smit, J Borst Critical Reviews™ in Oncogenesis 8 (4), 1997 | 84 | 1997 |
| Uncoupling DNA damage from chromatin damage to detoxify doxorubicin X Qiao, SY van der Zanden, DPA Wander, DM Borrās, JY Song, X Li, ... Proceedings of the National Academy of Sciences 117 (26), 15182-15192, 2020 | 83 | 2020 |
| CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia J Naik, M Themeli, R de Jong-Korlaar, RWJ Ruiter, PJ Poddighe, H Yuan, ... Haematologica 104 (3), e100, 2019 | 81 | 2019 |
| Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase GM Dingjan, A Maas, MC Nawijn, L Smit, JSA Voerman, F Grosveld, ... The EMBO journal 17 (18), 5309-5320, 1998 | 70 | 1998 |
| An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation L Smit, K Berns, K Spence, WD Ryder, N Zeps, M Madiredjo, ... Oncotarget 7 (3), 2596, 2016 | 69 | 2016 |
| Normal hematopoietic stem cells within the AML bone marrow have a distinct and higher ALDH activity level than co-existing leukemic stem cells GJ Schuurhuis, MH Meel, F Wouters, LA Min, M Terwijn, NA de Jonge, ... PloS one 8 (11), e78897, 2013 | 67 | 2013 |
| Disruption of the SCL locus in T-lymphoid malignancies correlates with commitment to the T-cell receptor alpha beta lineage EA Macintyre, L Smit, J Ritz, IR Kirsch, JL Strominger | 63 | 1992 |
| Binding of cell-surface expressed CD44 to hyaluronate is dependent on splicing and cell type R Vandervoort, E Mantenhorst, L Smit, E Ostermann, F Vandenberg, ... Biochemical and biophysical research communications 214 (1), 137-144, 1995 | 62 | 1995 |
| MicroRNA Profiling Can Classify Acute Leukemias of Ambiguous Lineage as Either Acute Myeloid Leukemia or Acute Lymphoid LeukemiamiRNA-Based Classification of Acute Leukemias DC de Leeuw, W van den Ancker, F Denkers, RX de Menezes, ... Clinical Cancer Research 19 (8), 2187-2196, 2013 | 56 | 2013 |
| The fate of the three subunits of major histocompatibility complex class I molecules JJ Neefjes, L Smit, M Gehrmann, HL Ploegh European journal of immunology 22 (6), 1609-1614, 1992 | 53 | 1992 |
| Escape from treatment; the different faces of leukemic stem cells and therapy resistance in acute myeloid leukemia N Van Gils, F Denkers, L Smit Frontiers in oncology 11, 659253, 2021 | 51 | 2021 |
David C. de LeeuwMD. PhD. Internist-hematologistGeverifieerd e-mailadres voor vumc.nl
